Geoffrey B. Hall
St. Joseph's Healthcare Hamilton
PsychiatryDevelopmental psychologyPsychologyBipolar disorderMajor depressive disorder
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Publications 125
#1Laura Han (VU: VU University Amsterdam)H-Index: 3
#2Richard Dinga (Radboud University Nijmegen)H-Index: 2
Last. Klaus Berger (WWU: University of Münster)H-Index: 70
view all 146 authors...
Major depressive disorder (MDD) is associated with an increased risk of brain atrophy, aging-related diseases, and mortality. We examined potential advanced brain aging in adult MDD patients, and whether this process is associated with clinical characteristics in a large multicenter international dataset. We performed a mega-analysis by pooling brain measures derived from T1-weighted MRI scans from 19 samples worldwide. Healthy brain aging was estimated by predicting chronological age (18–75 yea...
#1Randriely Merscher Sobreira de Lima (UFRGS: Universidade Federal do Rio Grande do Sul)H-Index: 1
#2Barbara Barth (McGill University)H-Index: 2
Last. Ana Paula Santana de Vasconcellos Bittencourt (UFES: Universidade Federal do Espírito Santo)
view all 13 authors...
#1Stefanie Hassel (Centre for Mental Health)H-Index: 18
#2Gulshan B. Sharma (U of C: University of Calgary)H-Index: 5
Last. Glenda MacQueen (Centre for Mental Health)H-Index: 57
view all 16 authors...
Task-based functional neuroimaging methods are increasingly being used to identify biomarkers of treatment response in psychiatric disorders. To facilitate meaningful interpretation of neural correlates of tasks and their potential changes with treatment over time, understanding the reliability of the blood-oxygen-level dependent (BOLD) signal of such tasks is essential. We assessed test-retest reliability of an emotional conflict task in healthy participants collected as part of the Canadian Bi...
#2Daan van RooijH-Index: 12
Last. Alan AnticevicH-Index: 35
view all 221 authors...
Objective Attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), and obsessive-compulsive disorder (OCD) are common neurodevelopmental disorders that frequently co-occur. We aimed to directly compare all three disorders. The ENIGMA consortium is ideally positioned to investigate structural brain alterations across these disorders. Methods Structural T1-weighted whole-brain MRI of controls (n=5,827) and patients with ADHD (n=2,271), ASD (n=1,777), and OCD (n=2,323) from ...
Variations in serotoninergic signaling have been related to behavioral outcomes. Alterations in the genome, such as DNA methylation and histone modifications, are affected by serotonin neurotransmission. The amygdala is an important brain region involved in emotional responses and impulsivity, which receives serotoninergic input. In addition, studies suggest that the serotonin transporter gene network may interact with the environment and influence the risk for psychiatric disorders. We propose ...
#1Gésine L. Alders (McMaster University)
#2Andrew D. Davis (McMaster University)H-Index: 3
view all 18 authors...
Abstract Background Identifying objective biomarkers can assist in predicting remission/non-remission to treatment, improving remission rates, and reducing illness burden in major depressive disorder (MDD). Methods Sixteen MDD 8-week remitters (MDD-8), twelve 16-week remitters (MDD-16), 14 non-remitters (MDD-NR) and 30 healthy comparison participants (HC) completed a functional magnetic resonance imaging emotional conflict task at baseline, prior to treatment with escitalopram, and 8 weeks after...
#1Tashia PetkerH-Index: 2
#2Jane DeJesus (McMaster University)
Last. Geoffrey B. HallH-Index: 26
view all 12 authors...
There is some evidence that cannabis use is associated with lower cognitive performance and symptoms of attention-deficit/hyperactivity disorder (ADHD), but the existing literature is relatively inconsistent, potentially due to small samples in previous studies. Using a dimensional design, the current study examined cannabis use severity and age of first cannabis use in relation to neurocognitive performance and ADHD symptoms in a large sample of community adults (N = 1,008, Mage = 38.49, 56.0% ...
#1Rachelle A. Ho (McMaster University)H-Index: 1
#2Geoffrey B. Hall (McMaster University)H-Index: 26
Last. Carol DeMatteo (McMaster University)H-Index: 18
view all 4 authors...
Background: Post-concussive depression describes an elevation of depressive symptoms following concussion that occurs in conjunction with other symptoms of concussion. Children with concuss...
#1Jee Su Suh (St. Joseph's Healthcare Hamilton)
#1Jee Su Suh (St. Joseph's Healthcare Hamilton)
Last. Benicio N. Frey (St. Joseph's Healthcare Hamilton)H-Index: 40
view all 17 authors...
Abstract Major depressive disorder (MDD) is considered a highly heterogeneous clinical and neurobiological mental disorder. We employed a novel layered treatment design to investigate whether cortical thickness features at baseline differentiated treatment responders from non-responders after 8 and 16 weeks of a standardized sequential antidepressant treatment. Secondary analyses examined baseline differences between MDD and controls as a replication analysis and longitudinal changes in thicknes...
#1Nikita Nogovitsyn (Centre for Mental Health)H-Index: 1
#2Meghan Muller (U of C: University of Calgary)H-Index: 1
Last. Glenda MacQueen (U of C: University of Calgary)H-Index: 57
view all 23 authors...
Finding a clinically useful neuroimaging biomarker that can predict treatment response in patients with major depressive disorder (MDD) is challenging, in part because of poor reproducibility and generalizability of findings across studies. Previous work has suggested that posterior hippocampal volumes in depressed patients may be associated with antidepressant treatment outcomes. The primary purpose of this investigation was to examine further whether posterior hippocampal volumes predict remis...