Young-Ho Byun
Yonsei University
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Publications 30
#1Hye Min Lee (Yonsei University)H-Index: 3
#2Soon Bin Kwon (Yonsei University)H-Index: 4
Last. Baik Lin SeongH-Index: 32
view all 11 authors...
Intrinsic disorders are a common feature of hub proteins in eukaryotic interactomes controlling the signaling pathways. The intrinsically disordered proteins (IDPs) are prone to misfolding, and maintaining their functional stability remains a major challenge in validating their therapeutic potentials. Considering that IDPs are highly enriched in RNA-binding proteins (RBPs), here we reasoned and confirmed that IDPs could be stabilized by fusion to RBPs. Dickkopf2 (DKK2), Wnt antagonist and a prot...
#1Eun-Sook Park (Konkuk University)H-Index: 11
#2Young-Ho Byun (Yonsei University)H-Index: 14
Last. Kyun-Hwan Kim (Konkuk University)H-Index: 22
view all 25 authors...
: The multifunctional influenza virus protein PB1-F2 plays several roles in deregulation of host innate immune responses and is a known immunopathology enhancer of the 1918 influenza pandemic. Here, we show that the 1918 PB1-F2 protein not only interferes with the mitochondria-dependent pathway of type I interferon (IFN) signaling, but also acquired a novel IFN antagonist function by targeting the DEAD-box helicase DDX3, a key downstream mediator in antiviral interferon signaling, toward proteas...
3 CitationsSource
#1Yung-soo Kim (Yonsei University)H-Index: 75
#2Ahyun Son (Yonsei University)H-Index: 6
Last. Baik Lin Seong (Yonsei University)H-Index: 32
view all 16 authors...
The folding of monomeric antigens and their subsequent assembly into higher ordered structures are crucial for robust and effective production of nanoparticle (NP) vaccines in a timely and reproducible manner. Despite significant advances in in silico design and structure-based assembly, most engineered NPs are refractory to soluble expression and fail to assemble as designed, presenting major challenges in the manufacturing process. The failure is due to a lack of understanding of the kinetic p...
7 CitationsSource
#1Yo Han Jang (Yonsei University)H-Index: 9
#2Joo Young Kim (Ewha Womans University)H-Index: 20
Last. Baik Lin Seong (Yonsei University)H-Index: 32
view all 8 authors...
Influenza virus infections continually pose a major public health threat with seasonal epidemics and sporadic pandemics worldwide. While currently licensed influenza vaccines provide only strain-specific protection, antigenic drift and shift occasionally render the viruses resistant to the host immune responses, which highlight the need for a vaccine that provides broad protection against multiple subtypes. In this study, we suggest a vaccination strategy using cold-adapted, live attenuated infl...
2 CitationsSource
#1Seung Won Yang (Yonsei University)H-Index: 2
#2Yo Han Jang (Yonsei University)H-Index: 9
Last. Baik Lin Seong (Yonsei University)H-Index: 32
view all 13 authors...
A novel protein-folding function of RNA has been recognized, which can outperform previously known molecular chaperone proteins. The RNA as a molecular chaperone (chaperna) activity is intrinsic to...
7 CitationsSource
#1Yun H. Lee (Yonsei University)H-Index: 1
#2Yo Han Jang (Yonsei University)H-Index: 9
Last. Baik Lin Seong (Yonsei University)H-Index: 32
view all 14 authors...
Traditionally, chemical agents such as formalin (FA) and β-propiolactone (BPL) have long been used for the preparation of inactivated vaccines or toxoids. It has been shown that FA extensively modifies vaccine antigens and thus affects immunogenicity profiles, sometimes compromising the protective efficacy of the vaccines or even exacerbating the disease upon infection. In this study, we show that natural catechins from green tea extracts (GT) can be used as an inactivating agent to prepare inac...
1 CitationsSource
#1Yoon Jae Lee (Yonsei University)H-Index: 6
#2Yo Han Jang (Yonsei University)H-Index: 9
Last. Baik Lin Seong (Yonsei University)H-Index: 32
view all 9 authors...
In our previous study, X-31ca-based H5N1 LAIVs, in particular, became more virulent in mice than the X-31ca MDV, possibly by the introduction of the surface antigens of highly pathogenic H5N1 influenza virus, implying that additional attenuation is needed in this cases to increase the safety level of the vaccine. In this report we suggest an approach to further increase the safety of LAIV through additional cold-adapted mutations in the hemagglutinin. The cold-adaptation of X-31 virus resulted i...
3 CitationsSource
#1Yo Han Jang (Yonsei University)H-Index: 9
#2Eun Ju Jung (Yonsei University)H-Index: 5
Last. Baik Lin Seong (Yonsei University)H-Index: 32
view all 6 authors...
Cold-adapted live attenuated influenza vaccines (CAIVs) have been considered as a safe prophylactic measure to prevent influenza virus infections. The safety of a CAIV depends largely on genetic markers that confer specific attenuation phenotypes. Previous studies with other CAIVs reported that polymerase genes were primarily responsible for the attenuation. Here, we analyzed the genetic mutations and their phenotypic contribution in the X-31 ca strain, a recently developed alternative CAIV dono...
9 CitationsSource
#1Doo Hee Shim (Yonsei University)H-Index: 4
#2Y. A. Park (Yonsei University)H-Index: 1
Last. Jae Myun Lee (Yonsei University)H-Index: 24
view all 16 authors...
Background The pandemic strain of the influenza A virus (pH1N1) in 2009 caused many complications in patients. In this study, we introduce asthmatic symptoms as a complication of pH1N1 infection in children, not having a relationship with asthma history. The aim of this study was to quantify asthmatic symptoms in pH1N1-infected children and elucidate the underlying mechanisms of airway hyper-responsiveness (AHR) induced in a murine model of pH1N1 infection. Methods As a retrospective study, pH1N...
6 CitationsSource
#1Eun Do Kim (Yonsei University)H-Index: 2
#2Soo Jung Han (Yonsei University)H-Index: 7
Last. SeoKyoung Yul (Yonsei University)H-Index: 27
view all 7 authors...
The eye route has been evaluated as an efficient vaccine delivery routes. However, in order to induce sufficient antibody production with inactivated vaccine, testing of the safety and efficacy of the use of inactivated antigen plus adjuvant is needed. Here, we assessed various types of adjuvants in eyedrop as an anti-influenza serum and mucosal Ab production-enhancer in BALB/c mice. Among the adjuvants, poly (I:C) showed as much enhancement in antigen-specific serum IgG and mucosal IgA antibody...
8 CitationsSource