Bong Soo Cha
Yonsei University
Publications 439
#1Hannah Seok (Catholic University of Korea)H-Index: 6
#2Min Young Lee (Yonsei University)H-Index: 10
Last.Eun Seok Kang (Yonsei University)H-Index: 33
view all 12 authors...
Amyloid-β (Aβ) accumulation in the brain is a pathological feature of Alzheimer’s disease (AD) and enhancing Aβ clearance is a potential therapeutic strategy. Pioglitazone is a peroxisome proliferator-activated receptor-γ (PPAR-γ) agonist and is widely used to treat type 2 diabetes. We previously reported that low-dose pioglitazone increased the expression of low-density lipoprotein receptor-related protein 1 (LRP1), which upregulates the clearance of Aβ, using human brain microvascular endothel...
#1Yongin ChoH-Index: 6
#2Namki HongH-Index: 8
Last.Byung-Wan LeeH-Index: 29
view all 0 authors...
The effects of an intermittent fasting diet (IFD) in the general population are still controversial. In this study, we aimed to systematically evaluate the effectiveness of an IFD to reduce body mass index and glucose metabolism in the general population without diabetes mellitus. Cochrane, PubMed, and Embase databases were searched to identify randomized controlled trials and controlled clinical trials that compared an IFD with a regular diet or a continuous calorie restriction diet. The effect...
#1Yongin Cho (Yonsei University)H-Index: 6
#2Yong-ho Lee (Yonsei University)H-Index: 23
Last.Byung-Wan Lee (Yonsei University)H-Index: 29
view all 5 authors...
Abstract Objective We investigated the clinical relevance of non-albumin proteinuria (NAP) in Korean patients with type 2 diabetes (T2D). Research design and methods We enrolled 883 T2D patients who had both their urinary albumin-to-creatinine ratio (uACR) and protein-to-creatinine ratio (uPCR) measured. We classified the patients into non-proteinuria (NP; uPCR Results The glucometabolic pathophysiology of iNAP (96 [10.9%]) group was more associated with a decrease in homeostatic model assessmen...
#1Ghi Su Kim (Yonsei University)H-Index: 28
#2Myungeun Yoo (Yonsei University)
Last.Belong Cho (Yonsei University)H-Index: 40
view all 9 authors...
Purpose Targeted therapy using phosphatidylinositol 3-kinase (PI3K) inhibitors is used to treat cancer such as lymphoma. In animal studies, its use raised concern about alteration of glucose metabolism. To date, clinical data are inconclusive; therefore, we investigated the incidence and clinical manifestations of diabetes in cancer patients treated with PI3K inhibitors.
#1Ji-Yeon Lee (Yonsei University)H-Index: 10
#2Kyungdo Han (CUA: The Catholic University of America)H-Index: 19
Last.Carol Brayne (University of Cambridge)H-Index: 101
view all 11 authors...
#1Jaehyun BaeH-Index: 1
#2Ji-Yeon LeeH-Index: 10
Last.Bong Soo ChaH-Index: 39
view all 11 authors...
Background: Obese individuals with normal metabolic profiles, so-called “metabolically healthy obese (MHO)” status has shown better clinical outcomes via previous studies. However, studies dealing with the association between MHO and dementia, which is deeply associated with metabolic disorders, were still insufficient. We designed this study to assess the association between MHO and the risk of incident dementia. Methods: The present study is a retrospective cohort study, including 5,669,488 pa...
#1Ghi Su Kim (SMC: Samsung Medical Center)H-Index: 28
#2Sang-Guk Lee (Yonsei University)H-Index: 12
Last.N. H. Cho (Ajou University)H-Index: 40
view all 8 authors...
Aims/hypothesis Ketones may be regarded as a thrifty fuel for peripheral tissues, but their clinical prognostic significance remains unclear. We investigated the association between spontaneous fasting ketonuria and incident diabetes in conjunction with changes in metabolic variables in a large population-based observational study.