Ruxing Zhao
Shandong University
EndocrinologyType 2 diabetesInsulinDiabetes mellitusMedicine
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Publications 19
#1Qin He (SDU: Shandong University)H-Index: 3
#2Lingshu Wang (SDU: Shandong University)H-Index: 8
Last. Mengmeng Yang (SDU: Shandong University)H-Index: 1
view all 17 authors...
Mesenchymal stem cell (MSC)-based therapy is currently considered to be an effective treatment strategy for diabetes and hepatic disorders, such as liver cirrhosis and non-alcoholic fatty liver disease. Exosomes are important mediators of cellular connections, and increasing evidence has suggested that exosomes derived from MSCs may be used as direct therapeutic agents; their mechanisms of action, however, remain largely unclear. Here, we evaluated the efficacy and molecular mechanisms of human ...
1 CitationsSource
#1Sha Sha (SDU: Shandong University)H-Index: 3
#2Xiaoming Liu (SDU: Shandong University)
Last. Li Chen (SDU: Shandong University)H-Index: 25
view all 7 authors...
Objective Metabolic syndrome is a chronic-metabolic disease caused by a variety of factors, including high peripheral blood insulin levels and insulin resistance. It has been reported that GLP-1 could regulate insulin resistance. It is not known whether and how GLP-1 protects from fat-induced inflammation and immune changes. We investigated if GLP-1 alters the populations of fat-induced inflammation and immune cells and the related mechanism.
#1Jun Song (Tongji University)H-Index: 2
#2Yeping Huang (SJTU: Shanghai Jiao Tong University)H-Index: 1
Last. Weiping Jia (SJTU: Shanghai Jiao Tong University)H-Index: 58
view all 9 authors...
Oxidative stress induced by free fatty acid aggravates endothelial injury, which leads to diabetic cardiovascular complications. Reduction of intracellular oxidative stress may attenuate these pathogenic processes. The dietary polyphenol resveratrol reportedly exerts potential protective effects against endothelial injury. This study determined whether resveratrol can reduce the palmitic acid (PA)-induced generation of reactive oxygen species (ROS) and further explored the underlying molecular m...
8 CitationsSource
#1Lingshu Wang (SDU: Shandong University)H-Index: 8
#2Li Qing (SDU: Shandong University)H-Index: 3
Last. Li Chen (SDU: Shandong University)H-Index: 25
view all 16 authors...
Islet dysfunction and destruction are the common cause for both type 1 and type 2 diabetes mellitus (T2DM). The islets of Langerhans are highly vascularized miniorgans, and preserving the structural integrity and full function of the microvascular endothelium is vital for protecting the islets from the infiltration of immune cells and secondary inflammatory attack. Mesenchymal stromal cell (MSC)-based therapies have been proven to promote angiogenesis of the islets; however, the underlying mecha...
6 CitationsSource
#1Tianyi HeH-Index: 5
#2Chuan WangH-Index: 8
Last. Xinguo HouH-Index: 11
view all 8 authors...
Aims. This study aimed to assess whether the electrochemical skin conductance (ESC) could be used to screen for diabetic cardiac autonomic neuropathy (DCAN) in a Chinese population with diabetes. Methods. We recruited 75 patients with type 2 diabetes mellitus (T2DM) and 45 controls without diabetes. DCAN was diagnosed by the cardiovascular autonomic reflex tests (CARTs) as gold standard. In all subjects ESCs of hands and feet were also detected by SUDOSCAN™ as a new screening method. The efficac...
4 CitationsSource
Purpose. To investigate the effects of Corbrin Capsule (CS-C-Q80), a drug derived from Cordyceps sinensis (Berk.) Sacc., on autoimmune thyroid diseases (AITD). Methods. 44 Patients with Graves’s disease (GD) and 56 patients with Hashimoto’s thyroiditis (HT) were randomly assigned to treatment group (GD-Tx and HT-Tx) or control group (GD-Ct and HT-Ct). The control groups were given methimazole or levothyroxine only while the treatment groups were given Corbrin Capsule (2.0 g tid) besides the same...
#1Xinguo HouH-Index: 11
#2Jinbo LiuH-Index: 5
Last. Li ChenH-Index: 25
view all 22 authors...
Objective. To investigate changes in the glycated hemoglobin A1c (A1c) level and those in β cell function and insulin resistance in newly diagnosed and drug naive type 2 diabetes patients and to evaluate the relationship between them. Design and Methods. A total of 818 newly diagnosed diabetic individuals who were ≥40 years of age were recruited. The subjects were grouped by A1c values (<6.5%, 6.5–7%, 7-8%, 8-9%, and ≥9%). The homeostasis model assessment (HOMA) was used to evaluate pancreatic β...
5 CitationsSource
#1Lingshu WangH-Index: 8
#2Jun SongH-Index: 10
Last. Li ChenH-Index: 25
view all 15 authors...
Betatrophin and irisin are two recently identified hormones which may participate in regulating pancreatic β-cell function. However, the associations of these two hormones with β-cell function remain unclear. The present study aims to demonstrate the associations of circulating betatrophin and irisin levels with β-cell function, assessed by the area under the curve (AUC) of C-peptide, and the possible correlation between these two hormones in previously diagnosed type 2 diabetes mellitus (T2DM) ...
13 CitationsSource
#1K. Wang (SDU: Shandong University)H-Index: 10
#2Yu Sun (SDU: Shandong University)H-Index: 10
Last. Li Chen (SDU: Shandong University)H-Index: 25
view all 11 authors...
: β-Cell insufficiency plays an important role in the development of diabetes. Environmental factors, including lifestyle, play a critical role in β-cell dysfunction. Modern lifestyles affect the inherent circadian clock in central and peripheral organs. Recent studies have demonstrated that the normal intrinsic circadian clock in islets was essential for the viability of β cells and their insulin secretory function. Overall, however, the data are inconclusive. Our study demonstrated that the di...
8 CitationsSource
#1Lingshu Wang (SDU: Shandong University)H-Index: 8
#2Peng Lin (SDU: Shandong University)H-Index: 10
Last. Li Chen (SDU: Shandong University)H-Index: 25
view all 16 authors...
Objective C-peptide has been reported to be a marker of subclinical atherosclerosis in type 2 diabetes mellitus (T2DM) patients, whereas its role in coronary artery disease (CAD) has not been clarified, especially in diabetics with differing body mass indices (BMIs). Design and Methods This cross-sectional study included 501 patients with T2DM. First, all subjects were divided into the following two groups: CAD and non-CAD. Then, binary logistic regression was used to determine the risk factors ...
11 CitationsSource