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Joseph C. González
Stanford University
3Publications
2H-index
22Citations
Publications 3
Newest
#1Michael N. Alonso (Stanford University)H-Index: 8
#2Josh G. Gregorio (Stanford University)H-Index: 1
Last.Edgar G. Engleman (Stanford University)H-Index: 79
view all 5 authors...
Monocytes rapidly infiltrate inflamed tissues and differentiate into CD209+ inflammatory dendritic cells (DCs) that promote robust immunity or, if unregulated, inflammatory disease. Previous studies in experimental animal models indicate that inflammatory DC depletion through systemic elimination of their monocyte precursors with clodronate-loaded liposomes ameliorates the development of psoriasis and other diseases. However, translation of systemic monocyte depletion strategies is difficult due...
#1Matthew G. Davidson (Stanford University)H-Index: 8
#2Michael N. Alonso (Stanford University)H-Index: 8
Last.Edgar G. Engleman (Stanford University)H-Index: 79
view all 7 authors...
Two critical functions of dendritic cells (DC) are to activate and functionally polarize T cells. Activated T cells can, in turn, influence DC maturation, although their effect on de novo DC development is poorly understood. Here we report that activation of T cells in mice, with either an anti-CD3 antibody or super antigen, drives the rapid formation of CD209+CD11b+CD11c+ MHC II+ DC from monocytic precursors (Mo-DC). GM-CSF is produced by T cells following activation, but surprisingly, it is no...
#1Matthew G. Davidson (Stanford University)H-Index: 8
#2Michael N. Alonso (Stanford University)H-Index: 8
Last.Edgar G. Engleman (Stanford University)H-Index: 79
view all 9 authors...
In chronically inflamed tissues, such as those affected by autoimmune disease, activated Th cells often colocalize with monocytes. We investigate in this study how murine Th cells influence the phenotype and function of monocytes. The data demonstrate that Th1, Th2, and Th17 subsets promote the differentiation of autologous monocytes into MHC class II+, CD11b+, CD11c+ DC that we call DCTh. Although all Th subsets induce the formation of DCTh, activated Th17 cells uniquely promote the formation o...
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