Joseph C. Gonzalez
Stanford University
ImmunologyMonocyteCD40Antigen-presenting cellBiology
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Publications 5
#1Saborni Chakraborty (Stanford University)
#2Karlie G. Edwards (Stanford University)
Last. Nimish Kathale (Stanford University)
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The ongoing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has caused a public health crisis that is exacerbated by our poor understanding of correlates of immunity. SARS-CoV-2 infection can cause Coronavirus Disease 2019 (COVID-19), with a spectrum of symptoms ranging from asymptomatic carriage to life threatening pneumonia and cytokine dysregulation [1-3]. Although antibodies have been shown in a variety of in vitro assays to promote coronavirus infections through mechan...
#2Joseph C. GonzalezH-Index: 2
Last. Michael N. AlonsoH-Index: 9
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Deficient anti-tumor immunity often results from an immunosuppressive tumor microenvironment (TME) that renders antigen presenting cells (APCs) unable to effectively stimulate T cells. Recent studies indicate that local delivery of immunostimulatory adjuvants can activate tumor resident APCs, driving uptake, processing and presentation of tumor neoantigens to T cells that mediate anti-tumor immunity. To overcome challenges associated with intratumoral delivery of such adjuvants, we developed a n...
1 CitationsSource
#1Michael N. Alonso (Stanford University)H-Index: 9
#2Josh G. Gregorio (Stanford University)H-Index: 1
Last. Edgar G. Engleman (Stanford University)H-Index: 80
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Monocytes rapidly infiltrate inflamed tissues and differentiate into CD209+ inflammatory dendritic cells (DCs) that promote robust immunity or, if unregulated, inflammatory disease. Previous studies in experimental animal models indicate that inflammatory DC depletion through systemic elimination of their monocyte precursors with clodronate-loaded liposomes ameliorates the development of psoriasis and other diseases. However, translation of systemic monocyte depletion strategies is difficult due...
2 CitationsSource
#1Matthew G. Davidson (Stanford University)H-Index: 8
#2Michael N. Alonso (Stanford University)H-Index: 9
Last. Edgar G. Engleman (Stanford University)H-Index: 80
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Two critical functions of dendritic cells (DC) are to activate and functionally polarize T cells. Activated T cells can, in turn, influence DC maturation, although their effect on de novo DC development is poorly understood. Here we report that activation of T cells in mice, with either an anti-CD3 antibody or super antigen, drives the rapid formation of CD209+CD11b+CD11c+ MHC II+ DC from monocytic precursors (Mo-DC). GM-CSF is produced by T cells following activation, but surprisingly, it is no...
4 CitationsSource
#1Matthew G. Davidson (Stanford University)H-Index: 8
#2Michael N. Alonso (Stanford University)H-Index: 9
Last. Edgar G. Engleman (Stanford University)H-Index: 80
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In chronically inflamed tissues, such as those affected by autoimmune disease, activated Th cells often colocalize with monocytes. We investigate in this study how murine Th cells influence the phenotype and function of monocytes. The data demonstrate that Th1, Th2, and Th17 subsets promote the differentiation of autologous monocytes into MHC class II+, CD11b+, CD11c+ DC that we call DCTh. Although all Th subsets induce the formation of DCTh, activated Th17 cells uniquely promote the formation o...
16 CitationsSource