Roy Taylor
Newcastle University
EndocrinologyType 2 diabetesInsulinDiabetes mellitusMedicine
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Publications 371
#1Philip M. Preshaw (Newcastle University)H-Index: 40
#2John J. Taylor (Newcastle University)H-Index: 26
Last. Aisha Areibi (Newcastle University)
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#1Sviatlana Zhyzhneuskaya (Newcastle University)H-Index: 5
#2Ahmad Al-Mrabeh (Newcastle University)H-Index: 10
Last. Roy Taylor (Newcastle University)H-Index: 47
view all 10 authors...
OBJECTIVE To assess functional β-cell capacity in type 2 diabetes during 2 years of remission induced by dietary weight loss. RESEARCH DESIGN AND METHODS A Stepped Insulin Secretion Test with Arginine was used to quantify functional β-cell capacity by hyperglycemia and arginine stimulation. Thirty-nine of 57 participants initially achieved remission (HbA1c RESULTS During remission, median (interquartile range) maximal rate of insulin secretion increased from 581 (480–811) pmol/min/m2 at baseline...
#1Ahmad Al-Mrabeh (Newcastle University)H-Index: 10
#2Sviatlana Zhyzhneuskaya (Newcastle University)H-Index: 5
Last. Roy Taylor (Newcastle University)H-Index: 47
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Summary The role of hepatic lipoprotein metabolism in diet-induced remission of type 2 diabetes is currently unclear. Here, we determined the contributions of hepatic VLDL1-triglyceride production rate and VLDL1-palmitic acid content to changes in intra-pancreatic fat and return of first phase insulin response in a subgroup of the Diabetes Remission Clinical Trial. Liver fat, VLDL1-triglyceride production, and intra-pancreatic fat decreased after weight loss and remained normalized after 24 mont...
#1M. D. Hopkins (Diabetes UK)H-Index: 1
#2Roy TaylorH-Index: 47
Last. Michael E. J. Lean (Glas.: University of Glasgow)H-Index: 79
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1 CitationsSource
#1Roy Taylor (Newcastle University)H-Index: 47
#2Ahmad Al-Mrabeh (Newcastle University)H-Index: 10
Last. Naveed Sattar (Glas.: University of Glasgow)H-Index: 119
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Summary Clinical and pathophysiological studies have shown type 2 diabetes to be a condition mainly caused by excess, yet reversible, fat accumulation in the liver and pancreas. Within the liver, excess fat worsens hepatic responsiveness to insulin, leading to increased glucose production. Within the pancreas, the β cell seems to enter a survival mode and fails to function because of the fat-induced metabolic stress. Removal of excess fat from these organs via substantial weight loss can normali...
3 CitationsSource
#1K BynoeH-Index: 1
#2Nigel Unwin (University of Cambridge)H-Index: 6
Last. Roy Taylor (Newcastle University)H-Index: 47
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#1Lucia Rehackova (Newcastle University)H-Index: 7
#2Vera Araujo-Soares (Newcastle University)H-Index: 20
Last. Falko F. Sniehotta (Newcastle University)H-Index: 43
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1 CitationsSource
#1Yiqiao XinH-Index: 5
#2Andrew DaviesH-Index: 3
Last. Michael E. J. LeanH-Index: 79
view all 9 authors...
Aim: The Counterweight‐Plus weight management programme achieved 46% remission of Type 2 diabetes at 1 year in the DiRECT trial. We estimated the implementation costs of the Counterweight‐Plus programme and its 1‐year cost‐effectiveness in terms of diabetes remission, compared with usual care, from the UK National Health Service (NHS) perspective. Methods: Within‐trial total costs included programme set‐up and running costs (practitioner appointment visits, low‐energy formula diet sachets and tr...
3 CitationsSource
#1David Houghton (Newcastle University)H-Index: 9
#2Paweł Zalewski (UMK: Nicolaus Copernicus University in Toruń)H-Index: 7
Last. Michael I. Trenell (Newcastle University)H-Index: 33
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Background & Aims Cardiovascular disease is the principle cause of death in patients with elevated liver fat unrelated to alcohol consumption, more so than liver-related morbidity and mortality. The aim of this study was to evaluate the relationship between liver fat and cardiac and autonomic function, as well as to assess how impairment in cardiac and autonomic function is influenced by metabolic risk factors. Methods Cardiovascular and autonomic function were assessed in 96 sedentary individua...
5 CitationsSource
#2Ahmad Al-MrabehH-Index: 10
Last. Roy TaylorH-Index: 47
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Aims: Observational studies have suggested that beta cell functional mass inevitably decreases over time. We assessed this after 2 years in a geographically defined subgroup of DiRECT who achieved initial remission after diet-induced weight loss. Methods: A Stepped Insulin Secretion Test with Arginine (SISTA) was used to quantify functional beta cell mass (maximum insulin secretory response during hyperglycemia). Insulin secretion rates were estimated by de-convolution; 40 subjects initially ach...