Vincent T. Ho
University of Sydney
ImmunologyHematopoietic stem cell transplantationTransplantationDiabetes mellitusMedicine
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Publications 559
#1Jerry Zhou (USYD: University of Sydney)H-Index: 5
#2Prapti Shrestha (USYD: University of Sydney)
Last. Vincent T. Ho (USYD: University of Sydney)H-Index: 77
view all 9 authors...
Non-erosive reflux disease (NERD) and esophageal adenocarcinoma (EAC) are often regarded as bookends in the gastroesophageal reflux disease spectrum. However, there is limited clinical evidence to support this disease paradigm while the underlying mechanisms of disease progression remain unclear. In this study, we used 16S rRNA sequencing and mass-spectrometer-based proteomics to characterize the esophageal microbiota and host mucosa proteome, respectively. A total of 70 participants from four p...
#1Daphne Foong (USYD: University of Sydney)H-Index: 2
Last. Michael D O'Connor (USYD: University of Sydney)H-Index: 17
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Millions of patients worldwide suffer from gastrointestinal (GI) motility disorders such as gastroparesis. These disorders typically include debilitating symptoms, such as chronic nausea and vomiting. As no cures are currently available, clinical care is limited to symptom management, while the underlying causes of impaired GI motility remain unaddressed. The efficient movement of contents through the GI tract is facilitated by peristalsis. These rhythmic slow waves of GI muscle contraction are ...
#1Matthew S. Davids (Harvard University)H-Index: 37
#2Haesook T. Kim (Harvard University)H-Index: 57
Last. Alexander P. Boardman (Harvard University)H-Index: 2
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Programmed cell death-1 (PD-1)/programmed death ligand-1 blockade may potentially augment graft-vs-tumor effects following allogeneic hematopoietic cell transplantation (alloHCT), but retrospective studies of anti-PD-1 therapy reported substantial toxicity from graft-versus-host-disease (GVHD). Here, we report the results of a prospective clinical trial of PD-1 blockade for relapsed hematologic malignancies (HMs) after alloHCT (NCT01822509). The primary objective in this phase 1 multicenter, inv...
1 CitationsSource
#1Sherrie J. Divito (Brigham and Women's Hospital)H-Index: 16
#2Anders T. Aasebo (Oslo University Hospital)
Last. Tobias Gedde-Dahl (Oslo University Hospital)H-Index: 29
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Graft-versus-host-disease (GVHD) is a major cause of morbidity and mortality in hematopoietic stem cell transplantation (HSCT). Donor T cells are key mediators in pathogenesis but a contribution from host T cells has not been explored, as conditioning regimens are believed to deplete host T cells. To evaluate a potential role for host T cells in GVHD, the origin of skin and blood T cells was assessed prospectively in patients after HSCT in the absence of GVHD. While blood contained primarily don...
#1Eduardo Espada (Harvard University)H-Index: 1
#2Matthew P. Cheng (Harvard University)H-Index: 14
Last. Mahasweta Gooptu (Harvard University)H-Index: 5
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Clinical disease caused by BK virus reactivation is a frequent complication of allogeneic hematopoietic cell transplantation (HCT). Because of the lack of effective antiviral agents, BK virus-specific T cells are emerging as a potential therapy for BK virus disease, but the immune response to BK virus after allogeneic HCT has not been well characterized. Our study describes reconstitution of BK virus-specific T-cell immunity in 77 adult patients after HCT. All patients had urinary symptoms, and ...
#1Vincent T. Ho (Harvard University)H-Index: 77
#2Andrew St Martin (Center for International Blood and Marrow Transplant Research)H-Index: 5
Last. Wael Saber (Center for International Blood and Marrow Transplant Research)H-Index: 30
view all 9 authors...
Abstract Gemtuzumab ozogamicin (GO) therapy prior to allogeneic hematopoietic cell transplantation (alloHCT) has been historically associated with an increased risk of hepatic veno-occlusive disease/sinusoidal obstruction syndrome (VOD/SOS) in patients with acute myeloid leukemia (AML). The current analysis examined VOD/SOS risk and outcomes in a cohort of patients who in recent years reported to the Center for International Blood & Marrow Transplant Research. Adults with AML who had GO exposure...
#1Ayman Saad (OSU: Ohio State University)H-Index: 21
#2Marcos de Lima (Case Western Reserve University)H-Index: 26
Last. S. Giralt (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 6
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Hematopoietic cell transplantation (HCT) involves the infusion of hematopoietic progenitor cells into patients with hematologic disorders with the goal of re-establishing normal hematopoietic and immune function. HCT is classified as autologous or allogeneic based on the origin of hematopoietic cells. Autologous HCT uses the patient's own cells while allogeneic HCT uses hematopoietic cells from a human leukocyte antigen-compatible donor. Allogeneic HCT is a potentially curative treatment option ...
2 CitationsSource
#1Pavan Bachireddy (Brigham and Women's Hospital)H-Index: 14
#2Christina Ennis (Harvard University)
Last. Natalie Bavli (UTSW: University of Texas Southwestern Medical Center)
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Resistance to the graft-versus-leukemia (GvL) effect remains the major barrier to successful allogeneic hematopoietic stem cell transplantation (allo-HSCT) for aggressive hematologic malignancies. The basis of GvL resistance for advanced lymphoid malignancies remains incompletely understood. We hypothesized that for patients with chronic lymphocytic leukemia (CLL) treated with allo-HSCT, leukemic cell-intrinsic features shape GvL outcomes by directing the evolutionary trajectories of CLL cells. ...
#1Zachariah DeFilipp (Harvard University)H-Index: 14
#2Shuli Li (Harvard University)H-Index: 20
Last. Corey Cutler (Harvard University)H-Index: 78
view all 21 authors...
In this multicenter Phase 2 single arm study, we substituted low dose total body irradiation (TBI) for antithymocyte globulin (ATG) in a reduced intensity conditioning regimen with the intent to lower the risk for viral infections after double umbilical cord blood (UCB) transplantation. The conditioning regimen consisted of fludarabine (30 mg/m2/day, Day −7 to −2), melphalan (100 mg/m2/day, Day −1), and TBI (200cGy, Day 0). Graft-versus-host disease prophylaxis was sirolimus and tacrolimus. Thir...
#1Angela Lek (Yale University)H-Index: 10
#2Yuanfan Zhang (Harvard University)H-Index: 4
Last. Andrew Kodani (Harvard University)H-Index: 1
view all 17 authors...
The emergence of CRISPR-Cas9 gene-editing technologies and genome-wide CRISPR-Cas9 libraries enables efficient unbiased genetic screening that can accelerate the process of therapeutic discovery for genetic disorders. Here, we demonstrate the utility of a genome-wide CRISPR-Cas9 loss-of-function library to identify therapeutic targets for facioscapulohumeral muscular dystrophy (FSHD), a genetically complex type of muscular dystrophy for which there is currently no treatment. In FSHD, both geneti...
2 CitationsSource