Vincent T. Ho
University of Sydney
ImmunologyHematopoietic stem cell transplantationGraft-versus-host diseaseTransplantationMedicine
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Publications 545
The DNA damage response enables cells to survive and maintain genome integrity. RAD52 is a DNA-binding protein involved in the homologous recombination in DNA repair, and is important for the maintenance of tumour genome integrity. We investigated possible correlations between RAD52 expression and cancer survival and response to preoperative radiotherapy. RAD52 expression was examined in tumour samples from 179 patients who underwent surgery for rectal cancer, including a sub-cohort of 40 patien...
Chronic GvHD affects about 30-60% of patients after allogeneic hematopoietic cell transplant (allo-HCT), and a majority exhibit ocular manifestations with significant impact on quality of life. In severe cases, oGvHD can lead to permanent vision loss. There is no FDA-approved treatment to date as the current options are limited and mostly ineffective. Forehead application of 1% progesterone gel (Pro-ocularTM) increases resistance to painful corneal stimuli in animal studies, as well as improves ...
#1Benedetta Rambaldi (UNIPV: University of Pavia)
#1Benedetta RambaldiH-Index: 5
Last. Edwin P. AlyeaH-Index: 72
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Haploidentical hematopoietic cell transplantation (haplo-HCT) with post-transplant cyclophosphamide (PTCy) as graft versus host disease (GVHD) prophylaxis is frequently used for patients who do not have HLA-identical donors. However, the effect of PTCy on immune reconstitution (IR) has not been studied extensively in large prospective cohorts, despite a high incidence of early viral infections. We quantified IR in 60 patients after haplo-HCT with PTCy, mycophenolate mofetil and tacrolimus (TAC) ...
#1Clinton W. Lewis (Auckland City Hospital)
#2Haesook T. Kim (Harvard University)H-Index: 57
Last. Vincent T. Ho (Harvard University)H-Index: 71
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ABSTRACT fludarabine with intravenous busulfan at doses of 3.2 mg/kg (Flu/Bu1) or 6.4mg/kg (Flu/Bu2) Hepatic veno-occlusive disease/sinusoidal obstruction syndrome (VOD/SOS) is a serious complication of hematopoietic stem cell transplantation (HCT) that is felt to be triggered, at least in part, by damage to the liver sinusoidal endothelium from cytotoxic conditioning regimens. Accordingly, the incidence of VOD/SOS after reduced-intensity conditioning (RIC) HCT is low compared with myeloablative...
#1Jerry ZhouH-Index: 5
Last. John D. BrannanH-Index: 4
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#1Vincent T. Ho (Harvard University)H-Index: 71
#2Andrew St. Martin (Center for International Blood and Marrow Transplant Research)H-Index: 5
Last. Wael Saber (Center for International Blood and Marrow Transplant Research)H-Index: 28
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Abstract Gemtuzumab ozogamicin (GO) therapy prior to allogeneic hematopoietic cell transplantation (alloHCT) has been historically associated with an increased risk of hepatic veno-occlusive disease/sinusoidal obstruction syndrome (VOD/SOS) in patients with acute myeloid leukemia (AML). The current analysis examined VOD/SOS risk and outcomes in a cohort of patients who in recent years reported to the Center for International Blood & Marrow Transplant Research. Adults with AML who had GO exposure...
#1Jacqueline S. Garcia (Harvard University)H-Index: 8
#2Lillian Werner (Harvard University)H-Index: 22
Last. Robert J. Soiffer (Harvard University)H-Index: 95
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#1Jonathan C. Poe (Duke University)H-Index: 36
Last. Frances T. Hakim (NIH: National Institutes of Health)H-Index: 32
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#1Vincent T. Ho (Harvard University)H-Index: 71
Last. William TappeH-Index: 2
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#1H. Moses Murdock (Harvard University)
#2Haesook T. Kim (Harvard University)H-Index: 57
Last. R. Coleman Lindsley (Harvard University)H-Index: 22
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