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Jonathan Tosh
University of Sheffield
45Publications
10H-index
537Citations
Publications 45
Newest
#1William H. CrownH-Index: 26
#2Nasuh Büyükkaramikli (EUR: Erasmus University Rotterdam)H-Index: 6
Last.Kalyan S. Pasupathy (Mayo Clinic)H-Index: 13
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Background: Constrained optimization methods are already widely used in health care to solve problems that represent traditional applications of operations research methods, such as choosing the optimal location for new facilities or making the most efficient use of operating room capacity. Objectives: In this paper we illustrate the potential utility of these methods for finding optimal solutions to problems in health care delivery and policy. To do so, we selected three award-winning papers in...
#1Naomi Martin ('KCL': King's College London)H-Index: 5
#2Fowzia Ibrahim ('KCL': King's College London)H-Index: 22
Last.Jacqueline Sturt ('KCL': King's College London)H-Index: 20
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Background Uncontrolled active rheumatoid arthritis can lead to increasing disability and reduced quality of life over time. ‘Treating to target’ has been shown to be effective in active established disease and also in early disease. However, there is a lack of nationally agreed treatment protocols for patients with established rheumatoid arthritis who have intermediate disease activity. This trial is designed to investigate whether intensive management of disease leads to a greater number of re...
#1Matt Stevenson (University of Sheffield)H-Index: 28
#2Allan Wailoo (National Health Service)H-Index: 28
Last.Adam YoungH-Index: 29
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Objective. To ascertain whether strategies of treatment with a biological disease-modifying antirheumatic drug (bDMARD) are cost-effective in an English setting. Results are presented for those patients with moderate to severe rheumatoid arthritis (RA) and those with severe RA. Methods. An economic model to assess the cost-effectiveness of 7 bDMARD was developed. A systematic literature review and network metaanalysis was undertaken to establish relative clinical effectiveness. The results were ...
#1Christopher James Sampson (University of Nottingham)H-Index: 6
#2Jonathan Tosh (University of Sheffield)H-Index: 10
Last.Marilyn James (University of Nottingham)H-Index: 13
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Background People with diabetic retinopathy tend to have lower levels of health-related quality of life than individuals with no retinopathy. Strategies for screening and treatment have been shown to be cost-effective. In order to reduce the bias in cost-effectiveness estimates, systematic reviews of health state utility values (HSUVs) are crucial for health technology assessment and the development of decision analytic models. A review and synthesis of HSUVs for the different stages of disease ...
#1Jason Madan (UoB: University of Bristol)H-Index: 18
#2Tony Ades (UoB: University of Bristol)H-Index: 5
Last.Jonathan Tosh (University of Sheffield)H-Index: 10
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Introduction Biologic therapies are efficacious but costly. A number of health economic models have been developed to determine the most cost-effective way of using them in the treatment pathway. These models have produced conflicting results, driven by differences in assumptions, model structure, and data, which undermine the credibility of funding decisions based on modeling studies. A Consensus Working Party met to discuss recommendations and approaches for future models of biologic therapies...
#1Jonathan Tosh (University of Sheffield)H-Index: 10
#2Matt Stevenson (University of Sheffield)H-Index: 28
Last.Ron Akehurst (University of Sheffield)H-Index: 24
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Systematic Review of combinatorial S-O Methods Methods • Reviews of methods require bespoke search methods[2] • Citation pearl growing search conducted, an effective search method for methodological literature[3] • A bespoke framework considered the development, theoretical basis and applicability of each paper • Excluded were multi-objective, naive, local search and non S-O methods Results • 28 papers were identified, either developing or applying a method for a combinatorial S-O problem • 17/2...
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