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Ayoung Baek
Gyeongsang National University
26Publications
6H-index
94Citations
Publications 26
Newest
Abstract Breast cancer is one of the major impediments affecting women globally. The ATP-dependant heat shock protein 90 (Hsp90) forms the central component of molecular chaperone machinery that predominantly governs the folding of newly synthesized peptides and their conformational maturation. It regulates the stability and function of numerous client proteins that are frequently upregulated and/or mutated in cancer cells, therefore, making Hsp90 inhibition a promising therapeutic strategy for ...
#1Raj Kumar (Gyeongsang National University)H-Index: 4
#2Saravanan Parameswaran (Gyeongsang National University)H-Index: 1
Last.Shraddha Parate (Gyeongsang National University)
view all 12 authors...
Abstract Prolyl oligopeptidase (POP) is a potential therapeutic target for treatment of several neurological disorders and α-synucleinopathies including Parkinson's disease. Most of the known POP inhibitors failed in the clinical trials due to poor pharmacokinetic properties and blood-brain impermeability. Therefore, a training set of 30 structurally diverse compounds with a wide range of inhibitory activity against POP was used to generate a quantitative pharmacophore model, Hypo 3, to identify...
#1Shailima Rampogu (Gyeongsang National University)H-Index: 6
#2Chanin Park (Gyeongsang National University)H-Index: 8
Last.Shraddha Parate (Gyeongsang National University)
view all 14 authors...
Breast cancer (BC) is the leading cause of death among women worldwide devoid of effective treatment. It is therefore important to develop agents that can reverse, reduce, or slow the growth of BC. The use of natural products as chemopreventive agents provides enormous advantages. The aim of the current investigation is to determine the efficacy of the phytochemicals against BC along with the approved drugs to screen the most desirable and effective phytocompound. In the current study, 36 phytoc...
#1Shailima RampoguH-Index: 6
#2Ayoung BaekH-Index: 6
Last.Seok Ju ParkH-Index: 6
view all 11 authors...
Angiogenesis is defined as the formation of new blood vessels and is a key phenomenon manifested in a host of cancers during which tyrosine kinases play a crucial role. Vascular endothelial growth factor receptor-2 (VEGFR-2) is pivotal in cancer angiogenesis, which warrants the urgency of discovering new anti-angiogenic inhibitors that target the signalling pathways. To obtain this objective, a structure-based pharmacophore model was built from the drug target VEGFR-2 (PDB code: 4AG8), complexed...
Dihydrofolate reductase (DHFR) is an essential cellular enzyme and thereby catalyzes the reduction of dihydrofolate to tetrahydrofolate (THF). In cancer medication, inhibition of human DHFR (hDHFR) remains a promising strategy, as it depletes THF and slows DNA synthesis and cell proliferation. In the current study, ligand-based pharmacophore modeling identified and evaluated the critical chemical features of hDHFR inhibitors. A pharmacophore model (Hypo1) was generated from known inhibitors of D...
#1Shailima Rampogu (Gyeongsang National University)H-Index: 6
#2Chanin Park (Gyeongsang National University)H-Index: 8
Last.Keun Woo Lee (Gyeongsang National University)H-Index: 29
view all 7 authors...
Abstract Globally, breast cancer is one of the primary reasons of death noticed in women. Despite continuous efforts to formulate effective treatments, search to identify promising therapeutics is underway. Consequently, a drug with low toxicity, high efficacy, and which can escape resistance mechanism is in a high demand. Natural compounds are bestowed with several medicinal properties demonstrating low toxicity. Therefore, the current research focuses on the use of several plant- derived chemi...
#1Shailima RampoguH-Index: 6
#2Amir ZebH-Index: 4
Last.Keun Woo LeeH-Index: 29
view all 6 authors...
Bacterial peptide deformylase (PDF) is an attractive target for developing novel inhibitors against several types of multidrug-resistant bacteria. The objective of the current study is to retrieve potential phytochemicals as prospective drugs against Staphylococcus aureus peptide deformylase (SaPDF). The current study focuses on applying ligand-based pharmacophore model (PharmL) and receptor-based pharmacophore (PharmR) approaches. Utilizing 20 known active compounds, pharmL was built and valida...
#1Shailima Rampogu (Gyeongsang National University)H-Index: 6
#2Ayoung Baek (Gyeongsang National University)H-Index: 6
Last.Keun Woo Lee (Gyeongsang National University)H-Index: 29
view all 4 authors...
Angiogenesis is a process of formation of new blood vessels and is an important criteria demonstrated by cancer cells. Over a period of time, these cancer cells infect the other parts of the healthy body by a process called progression. The objective of the present article is to identify a drug molecule that inhibits angiogenesis and progression. In this pursuit, ligand based pharmacophore virtual screening was employed, generating a pharmacophore model, Hypo1 consisting of four features. Furthe...
#1Shailima Rampogu (Gyeongsang National University)H-Index: 6
#2Ayoung Baek (Gyeongsang National University)H-Index: 6
Last.Keun Woo Lee (Gyeongsang National University)H-Index: 29
view all 9 authors...
Background Antibiotic resistance is a defense mechanism, harbored by pathogens to survive under unfavorable conditions. Among several antibiotic resistant microbial consortium, Staphylococcus aureus is one of the most havoc microorganisms. Staphylococcus aureus encodes a unique enzyme 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase (SaHPPK), against which, none of existing antibiotics have been reported.
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