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Julia A. Wagner
Washington University in St. Louis
Interleukin 12ImmunologyLymphokine-activated killer cellBiologyInterleukin 15
21Publications
8H-index
521Citations
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Publications 27
Newest
#1Julia A. Wagner (WashU: Washington University in St. Louis)H-Index: 8
#2Pamela Wong (WashU: Washington University in St. Louis)
Last. Jennifer A Foltz (WashU: Washington University in St. Louis)
view all 18 authors...
Summary Natural killer (NK) cells are cytotoxic innate lymphoid cells (ILCs) that mediate antiviral and antitumor responses and require the transcriptional regulator Eomesodermin (Eomes) for early development. However, the role of Eomes and its molecular program in mature NK cell biology is unclear. To address this, we develop a tamoxifen-inducible, type-1-ILC-specific (Ncr1-targeted) cre mouse and combine this with Eomes-floxed mice. Eomes deletion after normal NK cell ontogeny results in a rap...
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#1Carissa Dege (WashU: Washington University in St. Louis)H-Index: 2
#2Katherine H. Fegan (UR: University of Rochester)H-Index: 4
Last. Todd A. Fehniger (WashU: Washington University in St. Louis)H-Index: 43
view all 12 authors...
Summary Natural killer (NK) cells are a critical component of the innate immune system. However, their ontogenic origin has remained unclear. Here, we report that NK cell potential first arises from Hoxaneg/low Kit+CD41+CD16/32+ hematopoietic-stem-cell (HSC)-independent erythro-myeloid progenitors (EMPs) present in the murine yolk sac. EMP-derived NK cells and primary fetal NK cells, unlike their adult counterparts, exhibit robust degranulation in response to stimulation. Parallel studies using ...
1 CitationsSource
#1Madison R. Mack (WashU: Washington University in St. Louis)H-Index: 7
#2Jonathan R. Brestoff (WashU: Washington University in St. Louis)H-Index: 14
Last. Julia A. Wagner (WashU: Washington University in St. Louis)H-Index: 8
view all 26 authors...
Atopic dermatitis (AD) is a widespread, chronic skin disease associated with aberrant allergic inflammation. Current treatments involve either broad or targeted immunosuppression strategies. However, enhancing the immune system to control disease remains untested. We demonstrate that patients with AD harbor a blood natural killer (NK) cell deficiency that both has diagnostic value and improves with therapy. Multidimensional protein and RNA profiling revealed subset-level changes associated with ...
2 CitationsSource
#1Melissa M. Berrien-Elliott (WashU: Washington University in St. Louis)H-Index: 11
#2Wong Pamela (WashU: Washington University in St. Louis)
Last. Todd A. Fehniger (WashU: Washington University in St. Louis)H-Index: 43
view all 9 authors...
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#1Carissa Dege (WashU: Washington University in St. Louis)H-Index: 2
#2Katherine H. Fegan (URMC: University of Rochester Medical Center)H-Index: 1
Last. Christopher M. Sturgeon (WashU: Washington University in St. Louis)H-Index: 14
view all 11 authors...
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#1Melissa M. Berrien-Elliott (WashU: Washington University in St. Louis)H-Index: 11
#2Yaping Sun (UM: University of Michigan)H-Index: 26
Last. Todd A. Fehniger (WashU: Washington University in St. Louis)H-Index: 43
view all 24 authors...
Summary Natural killer (NK) cells are cytotoxic type 1 innate lymphoid cells (ILCs) that defend against viruses and mediate anti-tumor responses, yet mechanisms controlling their development and function remain incompletely understood. We hypothesized that the abundantly expressed microRNA-142 (miR-142) is a critical regulator of type 1 ILC biology. Interleukin-15 (IL-15) signaling induced miR-142 expression, whereas global and ILC-specific miR-142-deficient mice exhibited a cell-intrinsic loss ...
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Last. Todd A. FehnigerH-Index: 43
view all 14 authors...
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#1Melissa M. Berrien-Elliott (WashU: Washington University in St. Louis)H-Index: 11
#2Julia A. Wagner (WashU: Washington University in St. Louis)H-Index: 8
Last. Todd A. Fehniger (WashU: Washington University in St. Louis)H-Index: 43
view all 4 authors...
Natural killer (NK) cells, classically considered to be part of the innate immune system, are specialized for rapid responses that protect the host against pathogens and eliminate malignant cells. These functional responses are multi-faceted, and include not only direct target cell killing, but also production of cytokines and chemokines, proliferative expansion, and cross-talk with various immune cells to help orchestrate cellular immunity. NK cell recognition of a target cell is controlled by ...
1 CitationsSource
#1Carissa Dege (WashU: Washington University in St. Louis)H-Index: 2
#2Kathleen E. McGrath (URMC: University of Rochester Medical Center)H-Index: 26
Last. Christopher M. Sturgeon (WashU: Washington University in St. Louis)H-Index: 14
view all 8 authors...
Hematopoietic development during mammalian embryogenesis is comprised of a restricted primitive program of primitive erythroid, megakaryocytic, and macrophage lineages, and a definitive program of definitive erythroid, myeloid and lymphoid potential emerging from hematopoietic stem cell (HSC)-independent and dependent processes. Interestingly, progenitors of natural killer (NK) cells, but not B- or T-cells, have been found in the early human yolk sac, suggesting that NK cells may arise from HSC-...
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#1Christopher M. Sturgeon (WashU: Washington University in St. Louis)H-Index: 14
#2Carissa Dege (WashU: Washington University in St. Louis)H-Index: 2
Last. James Palis (UR: University of Rochester)H-Index: 44
view all 12 authors...
The derivation of natural killer (NK) cells from human pluripotent stem cells (hPSCs) is an exciting alternative for adoptive immunotherapy strategies in the treatment of cancer. While NK cells are component of the embryonic hematopoietic repertoire, their ontogenic origins remain unclear. During mammalian embryogenesis, hematopoietic development in the early yolk sac consists of the (HSC)-independent primitive and erythro-myeloid progenitor (EMP) hematopoietic programs. Neither population is kn...
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