Alice C. Wei
University Health Network
SurgeryHepatectomyPerioperativeGeneral surgeryMedicine
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Publications 49
#1Eric Xueyu ChenH-Index: 32
#2Derek J. Jonker (Ottawa Hospital)H-Index: 25
Last. Mohammed Harb (Moncton Hospital)H-Index: 1
view all 21 authors...
Importance: Single-agent immune checkpoint inhibition has not shown activities in advanced refractory colorectal cancer (CRC), other than in those patients who are microsatellite-instability high (MSI-H). Objective: To evaluate whether combining programmed death-ligand 1 (PD-L1) and cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) inhibition improved patient survival in metastatic refractory CRC. Design, Setting, and Participants: A randomized phase 2 study was conducted in 27 cancer centers...
2 CitationsSource
#1Benjamin LovedayH-Index: 11
#2Arash JaberiH-Index: 2
Last. Sean Cleary (Mayo Clinic)H-Index: 4
view all 13 authors...
Abstract Background Portal vein embolization (PVE) is used before major hepatectomy for hepatocellular carcinoma (HCC) to increase future liver remnant (FLR) volume. However, this may increase tumour growth rate, leading to more extensive resections. This study aimed to determine the effect of tumour growth, following PVE, on treatment plan. Method Retrospective cohort study conducted on patients treated from 2008 to 2015 with PVE before major hepatectomy for HCC. Liver and tumour volumetry was ...
#1M. Gabrielle Pagé (UdeM: Université de Montréal)H-Index: 11
#2Paul J. Karanicolas (U of T: University of Toronto)H-Index: 26
Last. Hance Clarke (UHN: University Health Network)H-Index: 20
view all 16 authors...
#1Lavanya Yohanathan (Mayo Clinic)H-Index: 1
#2Fahima Dossa (U of T: University of Toronto)H-Index: 4
Last. Sean Cleary (U of T: University of Toronto)H-Index: 4
view all 12 authors...
Abstract Background /Objective. To determine the outcomes of a non-operative management approach for sporadic, small, non-functional pancreatic neuroendocrine tumours. Methods A retrospective chart review of patients with non-functional pancreatic neuroendocrine tumours initially managed non-operatively at a single institution was performed. Patients were identified through a search of radiologic reports, and individuals with ≥2 cross-sectional imaging studies performed >6 months apart from Jan....
1 CitationsSource
#1Hagen F. Kennecke (Virginia Mason Medical Center)H-Index: 23
#2Carl J. Brown (St. Paul's Hospital)H-Index: 15
Last. Derek J. Jonker (Ottawa Hospital Research Institute)H-Index: 25
view all 14 authors...
TPS724Background: CO.28 is a phase II study which aims to determine if patients with stage I/II rectal cancer can be treated with induction chemotherapy (FOLFOX/CAPOX) and organ-preserving transana...
#1Benjamin Loveday (University of Auckland)H-Index: 11
#2Martin J. Dib (UW: University of Wisconsin-Madison)H-Index: 4
Last. Ian D. McGilvray (U of T: University of Toronto)H-Index: 41
view all 12 authors...
Abstract Background The left renal vein (LRV) may be used for venous reconstruction during hepato-pancreato-biliary (HPB) surgery, although concerns exist about compromising renal function. This study aimed to determine renal outcomes following LRV harvest during HPB resections. Methods Circumferential PV/SMV resections from 2008 to 2014 were included within two groups (LRV harvest, Control). Absolute and change in Creatinine (Cr) and estimated GFR (eGFR), and rates of acute kidney injury (AKI) ...
#1Melanie E. Tsang (U of T: University of Toronto)H-Index: 8
#2Alyson L. Mahar (UM: University of Manitoba)H-Index: 17
Last. Julie Hallet (U of T: University of Toronto)H-Index: 12
view all 9 authors...
#1Benjamin Loveday (University of Auckland)H-Index: 11
#2Nathan Zilbert (U of T: University of Toronto)H-Index: 3
Last. Ian D. McGilvray (U of T: University of Toronto)H-Index: 41
view all 22 authors...
Abstract Background Stage 3 pancreatic ductal adenocarcinoma (PDAC) is defined by arterial involvement. This study objective was to evaluate outcomes for patients with stage 3 PDAC with potentially reconstructable arterial involvement, considered for neoadjuvant therapy (NAT) and pancreatic resection, and to compare outcomes following arterial (AR) and non-arterial resection (NAR). Methods This study included patients from 2009 to 2016 with biopsy-proven stage 3 PDAC who were offered NAT before ...
#1Daniel J. Kagedan (U of T: University of Toronto)H-Index: 6
#2Alice C. Wei (U of T: University of Toronto)H-Index: 16
Initially described in the colorectal literature, enhanced recovery after surgery (ERaS) is a concept that emphasizes minimization of the physiologic disturbances produced by surgery – and focuses on interventions that minimize surgical stress – and promotes rapid recovery to presurgical levels of function. The introduction of ERaS protocols also provides a prime opportunity to additionally improve perioperative quality of care by systemizing the processes of care for patients according to the b...