John H. Page
Brigham and Women's Hospital
Publications 32
#1Pei-Hsuan Weng (NTU: National Taiwan University)H-Index: 5
#2Yi-Ling Huang (USDA: United States Department of Agriculture)H-Index: 4
Last.Yee-Chun Chen (NTU: National Taiwan University)H-Index: 49
view all 22 authors...
Background: Toll-like receptor 4 (TLR4) is one of the best known TLR members expressed on the surface of several leukocytes and tissue cells and has a key function in detecting pathogen and danger-associated molecular patterns. The role of TLR4 in the pathophysiology of several age-related diseases is also well recognized, such as prostate cancer (PCa). TLR4 polymorphisms have been related to PCa risk, but the relationship between TLR4 genotypes and aggressive PCa risk has not been evaluated by ...
8 CitationsSource
#1Sally Picciotto (University of California, Berkeley)H-Index: 19
#2Miguel A. Hernán (Harvard University)H-Index: 76
Last.James M. Robins (Harvard University)H-Index: 96
view all 5 authors...
In the presence of time-varying confounders affected by prior treatment, standard statistical methods for failure time analysis may be biased. Methods that correctly adjust for this type of covariate include the parametric g-formula, inverse probability weighted estimation of marginal structural Cox proportional hazards models, and g-estimation of structural nested accelerated failure time models. In this article, we propose a novel method to estimate the causal effect of a time-dependent treatm...
21 CitationsSource
#1Jennifer J. Shin (MEE: Massachusetts Eye and Ear Infirmary)H-Index: 17
#2Sandra S. Stinnett (Duke University)H-Index: 41
Last.W RandolphGregory (MEE: Massachusetts Eye and Ear Infirmary)H-Index: 38
view all 4 authors...
Recent studies have demonstrated that the majority of phy- sicians cannot accurately determine the predictive values of diagnostic tests. Physicians must understand the predictive probabilities associated with diagnostic testing in order to convey accurate information to patients, a key aspect of evidence-based practice. While sensitivity and specificity are widely understood, predictive values require a further understanding of conditional probabilities, pretest probabil- ities, and the prevale...
14 CitationsSource
#1Yi-Ling Huang (NTU: National Taiwan University)H-Index: 3
#2John H. Page (Brigham and Women's Hospital)H-Index: 17
Last.Yee-Chun Chen (NTU: National Taiwan University)H-Index: 49
view all 10 authors...
Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL Toll-like receptor 4 (TLR4) is located on the surface of macrophages and is important for the immune response to several pathogens. Chronic inflammation has been implicated in the pathogenesis of prostate cancer (PCa), and genetic polymorphisms of the innate immune gene TLR4 have been related to the risk of PCa. Six studies have explored the association between TLR4 polymorphisms and the risk of PCa. Five studies mainly inc...
#1Jennifer J. Shin (MEE: Massachusetts Eye and Ear Infirmary)H-Index: 17
#2John H. Page (Harvard University)H-Index: 17
Last.Michael J. Cunningham (MEE: Massachusetts Eye and Ear Infirmary)H-Index: 32
view all 5 authors...
Abstract Objective To develop and validate an instrument to measure the progression of clinical practice ability among surgical trainees. Study Design Prospective validation study. Setting Three academic training institutions: Massachusetts Eye and Ear Infirmary, Brigham and Women's Hospital, Harvard School of Public Health. Subjects and Methods A clinical practice instrument (CPI) was created and prospectively validated in otolaryngology trainees at three institutional sites. The instrument is ...
4 CitationsSource
#1John H. Page (Harvard University)H-Index: 17
#2Jixiang Ma (Brigham and Women's Hospital)H-Index: 99
Last.Eric B. Rimm (Harvard University)H-Index: 169
view all 7 authors...
Background Cysteine is a glutathione precursor, but is also a homocysteine byproduct. We prospectively evaluated relationships between fasting plasma concentrations of total cysteine and total homocysteine, and subsequent myocardial infarction (MI) in women. Methods Among 32,826 women who provided blood samples between 1989 and 1990, 239 were diagnosed with incident MI after blood collection, but before July 1998. Of these women, 144 had provided a postfast sample. We matched controls to cases 2...
21 CitationsSource
#1Sophia Koo (Harvard University)H-Index: 22
#2Julie M. Bryar (Harvard University)H-Index: 7
Last.Francisco M. Marty (Harvard University)H-Index: 44
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Background. Diagnosis of invasive fungal disease (IFD) is challenging, and it remains a significant cause of morbidity and mortality in immunocompromised patients. The (1→3)-β-D-glucan (BG) assay may be a useful adjunct, but its diagnostic performance is not well characterized. Methods. We retrospectively assessed the diagnostic indices of the BG assay in patients at risk of IFD who had a compatible clinical syndrome for the diagnosis of IFD a week after initial BG testing and at the end of the ...
161 CitationsSource
#1John H. PageH-Index: 17
#2Kathryn M. RexrodeH-Index: 73
Last.JoAnn E. MansonH-Index: 235
view all 6 authors...
Background: It is not yet established what specific measures of obesity might be most strongly associated with risk of coronary artery disease. We compared the waist-height ratio to waist-hip ratio, waist circumference, and body mass index as predictors of subsequent coronary heart disease (CHD) in a group of predominantly postmenopausal women. Methods: The data come from the prospective Nurses' Health Study cohort. We included 45,563 women in 1986 who were aged 40-65 years and were free of hear...
45 CitationsSource
#1John H. Page (Harvard University)H-Index: 17
#2Andrea Rotnitzky (Harvard University)H-Index: 40
We consider the estimation of the parameters indexing a parametric model for the conditional distribution of a diagnostic marker given covariates and disease status. Such models are useful for the evaluation of whether and to what extent a marker's ability to accurately detect or discard disease depends on patient characteristics. A frequent problem that complicates the estimation of the model parameters is that estimation must be conducted from observational studies. Often, in such studies not ...
11 CitationsSource