Match!
Martin Caffrey
Trinity College, Dublin
281Publications
56H-index
12.6kCitations
Publications 285
Newest
#1C.-Y. HuangH-Index: 5
#2Samir OlatunjiH-Index: 1
Last.Martin CaffreyH-Index: 56
view all 7 authors...
Source
#1C.-Y. HuangH-Index: 5
#2Samir OlatunjiH-Index: 1
Last.Martin CaffreyH-Index: 56
view all 7 authors...
Source
#1Jessica L Thomaston (UCSF: University of California, San Francisco)
#2Athina Konstantinidi (UoA: National and Kapodistrian University of Athens)H-Index: 2
Last.Nicolas Kolocouris (UoA: National and Kapodistrian University of Athens)H-Index: 23
view all 9 authors...
The V27A mutation confers adamantane resistance to the influenza A matrix 2 (M2) proton channel and is becoming more prevalent in circulating populations of influenza A virus. We have used X-ray crystallography to solve structures of a spiro-adamantyl amine inhibitor bound to M2(22-46) V27A and also to M2(21-61) V27A in the Inwardclosed conformation. The spiro-adamantyl amine binding site is nearly identical for the two crystal structures. Compared to the M2 “wild type” (WT) with valine at posit...
Source
#1Samir Olatunji (Trinity College, Dublin)H-Index: 1
#2C.-Y. Huang (Paul Scherrer Institute)H-Index: 5
Last.Joan A. Geoghegan (Trinity College, Dublin)H-Index: 25
view all 12 authors...
Antimicrobial resistance is a major global threat that calls for new antibiotics. Globomycin and myxovirescin are two natural antibiotics that target the lipoprotein-processing enzyme, LspA, thereby compromising the integrity of the bacterial cell envelope. As part of a project aimed at understanding their mechanism of action and for drug development, we provide high-resolution crystal structures of the enzyme from the human pathogen methicillin-resistant Staphylococcus aureus (MRSA) complexed w...
Source
#1Meriem El Ghachi (University of Liège)H-Index: 7
#2Nicole Howe (Trinity College, Dublin)H-Index: 8
Last.Martin Caffrey (Trinity College, Dublin)H-Index: 56
view all 11 authors...
As a protective envelope surrounding the bacterial cell, the peptidoglycan sacculus is a site of vulnerability and an antibiotic target. Peptidoglycan components, assembled in the cytoplasm, are shuttled across the membrane in a cycle that uses undecaprenyl-phosphate. A product of peptidoglycan synthesis, undecaprenyl-pyrophosphate, is converted to undecaprenyl-phosphate for reuse in the cycle by the membrane integral pyrophosphatase, BacA. To understand how BacA functions, we determine its crys...
5 CitationsSource
#1Wanchao YinH-Index: 1
#2X. Edward Zhou (CAS: Chinese Academy of Sciences)H-Index: 22
Last.Yi Jiang (CAS: Chinese Academy of Sciences)H-Index: 11
view all 21 authors...
5-hydroxytryptamine (5-HT, also known as serotonin) regulates many physiological processes through the 5-HT receptor family. Here we report the crystal structure of 5-HT1B subtype receptor (5-HT1BR) bound to the psychotropic serotonin receptor inverse agonist methiothepin (MT). Crystallization was facilitated by replacing ICL3 with a novel optimized variant of BRIL (OB1) that enhances the formation of intermolecular polar interactions, making OB1 a potential useful tool for structural studies of...
9 CitationsSource
#1Coilín Boland (Trinity College, Dublin)H-Index: 6
#2Samir Olatunji (Trinity College, Dublin)H-Index: 1
Last.Martin Caffrey (Trinity College, Dublin)H-Index: 56
view all 10 authors...
Label-free differential scanning fluorimetry (DSF) is a relatively new method for evaluating the stability of proteins. It can be used as a screening tool for downstream applications such as crystallization. The method is attractive in that it requires miniscule quantities of proteins, it can be performed using intrinsic tryptophan and tyrosine fluorescence, and, with the right equipment, it is easy to perform. To date, the method has been used with proteins in liquid solutions and dispersions. ...
2 CitationsSource
#1C.-Y. HuangH-Index: 5
#2Vincent OliericH-Index: 18
Last.Meitian WangH-Index: 26
view all 11 authors...
Source
#1C.-Y. HuangH-Index: 5
#2Vincent OliericH-Index: 18
Last.Meitian WangH-Index: 26
view all 11 authors...
Source
#1C.-Y. HuangH-Index: 5
#2Vincent OliericH-Index: 18
Last.Meitian WangH-Index: 26
view all 11 authors...
Source
12345678910