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Chuan-Chin Huang
Brigham and Women's Hospital
Internal medicineDiseaseTuberculosisMedicineBiology
14Publications
4H-index
76Citations
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Publications 17
Newest
#1Aparna Nathan (Brigham and Women's Hospital)H-Index: 1
#2Jessica I Beynor (Brigham and Women's Hospital)H-Index: 1
Last. Kattya López Tamara (Brigham and Women's Hospital)H-Index: 1
view all 17 authors...
Mycobacterium tuberculosis (M.tb) results in 10 million active tuberculosis (TB) cases and 1.5 million deaths each year, making it the world9s leading infectious cause of death. Infection leads to either an asymptomatic latent state or TB disease. Memory T cells have been implicated in TB disease progression, but the specific cell states involved have not yet been delineated because of the limited scope of traditional profiling strategies. Furthermore, immune activation during infection confound...
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#1Sara Suliman (UCT: University of Cape Town)H-Index: 11
#2Anele Gela (UCT: University of Cape Town)H-Index: 1
Last. Alexandra J. Corbett (University of Melbourne)H-Index: 24
view all 36 authors...
BACKGROUND: In human blood, mucosal-associated invariant T (MAIT) cells are abundant T cells, which recognize antigens presented on non-polymorphic major histocompatibility complex-related 1 (MR1) molecules. MAIT cells are activated by mycobacteria, and prior human studies indicate that blood frequencies of MAIT cells, defined by cell surface markers, decline during TB disease, consistent with redistribution to the lungs. METHODS: We tested whether frequencies of blood MAIT cells were altered in...
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Few studies have prospectively compared the relative transmissibility and propensity to cause disease of Mycobacterium tuberculosis Beijing strains with other human-adapted strains of the M. tuberculosis complex. We assessed the effect of Beijing strains on the risk for M. tuberculosis infection and disease progression in 9,151 household contacts of 2,223 culture-positive pulmonary tuberculosis (TB) patients in Lima, Peru. Child contacts exposed to Beijing strains were more likely than child con...
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#1Ruoran Li (Harvard University)H-Index: 3
#1Ruoran Li (Harvard University)H-Index: 1
Last. Megan Murray (Harvard University)H-Index: 57
view all 11 authors...
BACKGROUND: Efficient contact investigation strategies are needed for the early diagnosis of TB disease and treatment of latent TB infections. METHODS: Between September 2009 and August 2012, we conducted a prospective cohort study in Lima, Peru in which we enrolled and followed 14,044 household contacts of adult pulmonary TB patients. We used information from a subset of this cohort to derive two clinical prediction tools that identify contacts of TB patients at elevated risk of progressing to ...
1 CitationsSource
#1Mercedes C. Becerra (Harvard University)H-Index: 33
#2Chuan-Chin Huang (Brigham and Women's Hospital)H-Index: 4
Last. Megan Murray (Harvard University)H-Index: 57
view all 14 authors...
Abstract Objective To measure the association between phenotypic drug resistance and the risk of tuberculosis infection and disease among household contacts of patients with pulmonary tuberculosis. Setting 106 district health centers in Lima, Peru between September 2009 and September 2012. Design Prospective cohort study. Participants 10 160 household contacts of 3339 index patients with tuberculosis were classified on the basis of the drug resistance profile of the patient: 6189 were exposed to...
3 CitationsSource
#1Omowunmi Aibana (University of Texas Health Science Center at Houston)H-Index: 4
#2Chuan-Chin Huang (Harvard University)H-Index: 4
Last. Megan Murray (Harvard University)H-Index: 57
view all 40 authors...
Background Few studies have evaluated the association between preexisting vitamin D deficiency and incident tuberculosis (TB). We assessed the impact of baseline vitamins D levels on TB disease risk. Methods and findings We assessed the association between baseline vitamin D and incident TB in a prospective cohort of 6,751 HIV-negative household contacts of TB patients enrolled between September 1, 2009, and August 29, 2012, in Lima, Peru. We screened for TB disease at 2, 6, and 12 months after ...
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#1Chuan-Chin Huang (Brigham and Women's Hospital)H-Index: 4
#2Mercedes C. Becerra (Harvard University)H-Index: 33
Last. Megan Murray (Harvard University)H-Index: 57
view all 10 authors...
Background: World Health Organization recommend the use of isoniazid (INH) only, or INH and rifapentine therapy, to treat the latent tuberculosis infection (LTBI). The recent rise of isoniazid and multi-drug resistant (MDR) tuberculosis has complicated the choice of LTBI treatment regimen. The current lack of evidence on optimal regimens prevents the formulation of definitive recommendations for latent drug-resistant tuberculosis. We examine the risk of disease progression of individuals exposed...
1 CitationsSource
#1Omowunmi Aibana (University of Texas at Austin)
#2Chuan-Chin Huang (Brigham and Women's Hospital)H-Index: 4
Last. Megan Murray (Harvard University)H-Index: 57
view all 39 authors...
Background: Few studies have evaluated the association between pre-existing vitamin D deficiency (VDD) and incident TB. We assessed the impact of baseline vitamin D on TB disease risk. Methods: We nested a case-control study within a prospective cohort of household contacts of TB patients in Peru. We also conducted a one-stage individual participant data meta-analysis searching PubMed and Embase to identify studies of vitamin D and TB disease until December 31, 2017. We included studies that ass...
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#1Mercedes C. Becerra (Harvard University)H-Index: 33
#2Chuan-Chin Huang (Brigham and Women's Hospital)H-Index: 4
Last. Megan Murray (Harvard University)H-Index: 57
view all 14 authors...
Background: The future trajectory of drug resistant tuberculosis strongly depends on the fitness costs of drug resistance mutations. Here, we measured the association of phenotypic drug resistance and the risk of TB infection and disease among household contacts (HHCs) of patients with pulmonary TB. Methods: We evaluated 12767 HHCs of patients with drug sensitive and resistant pulmonary TB at baseline, two, six, and 12 months to ascertain infection status and to determine whether they developed ...
1 CitationsSource
#1Omowunmi Aibana (Brown University)H-Index: 4
#2Molly F. Franke (Brigham and Women's Hospital)H-Index: 20
Last. Megan Murray (Brigham and Women's Hospital)H-Index: 57
view all 12 authors...
4 CitationsSource
12