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Boyoun Park
Yonsei University
Molecular biologyMHC class IMajor histocompatibility complexTransporter associated with antigen processingBiology
38Publications
18H-index
1,936Citations
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Publications 39
Newest
#1Soo Mi Ki (SKKU: Sungkyunkwan University)H-Index: 3
#2Ji Hyun Kim (SKKU: Sungkyunkwan University)H-Index: 1
Last. 이지은 ( Ji Eun Lee ) (SKKU: Sungkyunkwan University)H-Index: 13
view all 11 authors...
The endothelial cilium is a microtubule‐based organelle responsible for blood flow‐induced mechanosensation and signal transduction during angiogenesis. The precise function and mechanisms by which ciliary mechanosensation occurs, however, are poorly understood. Although posttranslational modifications (PTMs) of cytoplasmic tubulin are known to be important in angiogenesis, the specific roles of ciliary tubulin PTMs play remain unclear. Here, we report that loss of centrosomal protein 41 (CEP41)...
Source
#1Areum Park (Yonsei University)H-Index: 7
#2Eun A. Ra (Yonsei University)H-Index: 5
Last. Boyoun Park (Yonsei University)H-Index: 18
view all 9 authors...
The mechanisms by which many human cytomegalovirus (HCMV)-encoded proteins help the virus to evade immune surveillance remain poorly understood. In particular, it is unknown whether HCMV proteins arrest Toll-like receptor (TLR) signaling pathways required for antiviral defense. Here, we report that US7 and US8 as key suppressors that bind both TLR3 and TLR4, facilitating their destabilization by distinct mechanisms. US7 exploits the ER-associated degradation components Derlin-1 and Sec61, promot...
1 CitationsSource
#1Eun Hye Lee (Yonsei University)H-Index: 6
#2Taeyun A. Lee (Yonsei University)H-Index: 6
Last. Boyoun Park (Yonsei University)H-Index: 18
view all 5 authors...
1 CitationsSource
#1Hyun jin Choi (Yonsei University)H-Index: 4
#2Areum Park (Yonsei University)H-Index: 7
Last. Boyoun Park (Yonsei University)H-Index: 18
view all 9 authors...
Human cytomegalovirus (HCMV) has evolved sophisticated immune evasion mechanisms that target both the innate and adaptive immune responses. However, how HCMV encoded proteins are involved in this immune escape is not clear. Here, we show that HCMV glycoprotein US9 inhibits the IFN-β response by targeting the mitochondrial antiviral-signaling protein (MAVS) and stimulator of interferon genes (STING)-mediated signaling pathways. US9 accumulation in mitochondria attenuates the mitochondrial membran...
15 CitationsSource
#1Hyunbin D. Huh (Yonsei University)H-Index: 2
#2Eun Hye Lee (Yonsei University)H-Index: 6
Last. Sung-Wook LeeH-Index: 15
view all 5 authors...
Abstract Toll-like receptor (TLR) signaling drives the innate immune response by activating nuclear factor-κB (NF-κB) and interferon regulatory factor (IRF). We have previously shown that STRAP interacts with TAK1 and IKKα along with NF-κB subunit p65, leading to the activation of pro-inflammatory cytokines. However, the roles of STRAP in TRIF/TBK1-mediated TLR3 activation and the subsequent type I interferon (IFN) production are not fully elucidated. Here, we demonstrate that STRAP acts as a sc...
1 CitationsSource
#1Eun Hye Lee (Yonsei University)H-Index: 6
#2Taeyun A. Lee (Yonsei University)H-Index: 6
Last. Boyoun Park (Yonsei University)H-Index: 18
view all 12 authors...
The transcription of inflammatory genes is an essential step in host defense activation. Here, we show that cellular nucleic acid-binding protein (CNBP) acts as a transcription regulator that is required for activating the innate immune response. We identified specific CNBP-binding motifs present in the promoter region of sustained inflammatory cytokines, thus, directly inducing the expression of target genes. In particular, lipopolysaccharide (LPS) induced cnbp expression through an NF-κB-depen...
7 CitationsSource
#1Hyunbin D. Huh (Yonsei University)H-Index: 2
#2Eun A. Ra (Yonsei University)H-Index: 5
Last. Boyoun ParkH-Index: 18
view all 11 authors...
4 CitationsSource
#1Eun A. Ra (Yonsei University)H-Index: 5
#2Taeyun A. Lee (Yonsei University)H-Index: 6
Last. Boyoun Park (Yonsei University)H-Index: 18
view all 12 authors...
While non-canonical, Atg5/Atg7-independent autophagy has been reported to occur, molecular details of alternative autophagy pathways remain unknown. Here, the authors report that the protein TRIM31 mediates alternative autophagy in intestinal cells, which protects against pathogenic bacteria.
19 CitationsSource
#1Sungwook Lee (Yonsei University)H-Index: 5
#2Taeyun A. Lee (Yonsei University)H-Index: 6
Last. Boyoun Park (Yonsei University)H-Index: 18
view all 5 authors...
Inclusion of Tat-activating regulatory DNA-binding protein-43 (TDP-43) due to hyperphosphorylation or hyperubiquitination is a cause of neurodegenerative disease. Cellular TDP-43 expression is tightly controlled through a negative feedback loop involving its mRNA. Recently, we reported that the TDP-43-mediated sub-nuclear body is an essential site of interleukin-6 (IL-6) pre-mRNA processing. Here we show that mice fed on a high-fat diet exhibit increased TDP-43 expression in the liver and adipos...
2 CitationsSource
Dysregulation of cytokine expression causes inflammatory diseases or chronic infection conditions. We have identified that Tat-activating regulatory DNA-binding protein-43 (TDP-43) is involved in cytokine RNA processing in order to promote an optimal immune response. The interaction of TDP-43 with spliceosomal components from the Cajal body leads to the formation of a novel sub-nuclear body called the Interleukin (IL)-6 and IL-10 Splicing Activating Compartment (InSAC). TDP-43 binds to the IL-6 ...
2 CitationsSource
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