Hsun-Shuo Chang
Kaohsiung Medical University
Publications 97
#1Yu-Hsuan Wu (NCKU: National Cheng Kung University)H-Index: 3
#2Chin-Kai Tseng (NCKU: National Cheng Kung University)H-Index: 10
Last.Jin-Ching LeeH-Index: 20
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Dengue virus (DENV) caused millions of infections around the world annually. Co-infection with different serotypes of DENV is associated with dengue hemorrhagic shock syndrome, leading to an estimate of 50% death rate. No approved therapies are currently available for the treatment of DENV infection. Hence, novel anti-DENV agents are urgently needed for medical therapy. Here we demonstrated that a natural product (2 R,4 R)-1,2,4-trihydroxyheptadec-16-yne (THHY), extracted from avocado (Persea am...
#1Ho-Cheng WuH-Index: 1
#2Ho-Cheng Wu (KMU: Kaohsiung Medical University)
Last.Hsun-Shuo ChangH-Index: 13
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Abstract A chemical study on the EtOAc-soluble fraction of the 95% EtOH extract of red yeast rice fermented with the fungus Monascus purpureus BCRC 38110 (Eurotiaceae) has resulted in the isolation of three new compounds, i.e ., two new 5′,6′-dihydrospiro[isochromane-1,2′-pyran]-4′(3′ H )-one derivatives, designated as monascuspirolide A ( 1 ) and monascuspirolide B ( 2 ) and one benzenoid derivative, monapurpureusin B ( 3 ), together with three known compounds, monaspurpurone ( 4 ), monascin ( ...
#1Kuan-Ju Feng (KMU: Kaohsiung Medical University)
#2Ming-Jen ChengH-Index: 18
Last.Hsun-Shuo Chang (KMU: Kaohsiung Medical University)H-Index: 13
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Fractionation of the BuOH-soluble fraction of the liquid fermentation of an endophytic fungus Ophiocordyceps sobolifer BCRC 38180 associated with the root of Taiwanese Ilex formosana (Aquifoliaceae) resulted in the isolation of one new diketopiperazine, soboliferamide (1), and one metabolite isolated for the first time from a natural source, cyclo-(Ile-Ser) (2), along with 18 previously identified compounds, 3–20. Their structures were elucidated by means of spectroscopic and mass-spectrometric ...
#1Ho-Cheng Wu (KMU: Kaohsiung Medical University)H-Index: 1
#2Ming-Jen ChengH-Index: 18
Last.Kai-Ping ChenH-Index: 2
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AbstractPhytochemical investigation of the EtOAc-soluble fraction of the ethanolic extract of a yellow mutant of the fungus Monascus purpureus BCRC 38110 (Eurotiaceae) grown on rice resulted in the isolation of one new azaphilone derivative, monapurpureusone (1), one acetophenone metabolite isolated for the first time from natural source, monapurpureusin (2), along with four known compounds, TW94a (3), ergosterol (4), monascin (5), and ankaflavin (6). The structures and relative configurations o...
Non-alcoholic fatty liver disease (NAFLD) has become the most common liver disease in the recent decades in both developed and developing countries, and is predicted to be the major etiology for liver transplantation in the next decade. Thus, pharmacological strategies to treat NAFLD are urgently needed. Natural products are considered an excellent source for drug discovery. By utilizing an image-based high-throughput screening with a library containing 3000 Taiwanese indigenous plant extracts, ...