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Hsun-Shuo Chang
Kaohsiung Medical University
Organic chemistryChemistryBiochemistryBotanyStereochemistry
89Publications
13H-index
508Citations
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Publications 90
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#1Ho-Cheng Wu (KMU: Kaohsiung Medical University)H-Index: 2
#2Ming-Jen ChengH-Index: 18
Last. Hsun-Shuo ChangH-Index: 13
view all 7 authors...
Hepatocellular carcinoma (HCC) is considered to be a silent killer, and was the fourth leading global cause of cancer deaths in 2018. For now, sorafenib is the only approved drug for advanced HCC treatment. The introduction of additional chemopreventive agents and/or adjuvant therapies may be helpful for the treatment of HCC. After screening 3000 methanolic extracts from the Formosan plant extract bank, Excoecaria formosana showed glycine N-methyltransferase (GNMT)-promoter-enhancing and nuclear...
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#1Wohn-Jenn Leu (NTU: National Taiwan University)H-Index: 5
#2Ching‐Ting Wang (NTU: National Taiwan University)H-Index: 1
Last. Jih-Hwa Guh (NTU: National Taiwan University)H-Index: 35
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BACKGROUND: Cardiac glycosides, which inhibit Na(+) /K(+) -ATPase, display inotropic effects for the treatment of congestive heart failure and cardiac arrhythmia. Recent studies have suggested signaling downstream of Na(+) /K(+) -ATPase action in the regulation of cell proliferation and apoptosis and have revealed the anticancer activity of cardiac glycosides. The study aims to characterize the anticancer potential of ascleposide, a natural cardenolide, and to uncover its primary target and unde...
1 CitationsSource
#1Ho-Cheng Wu (KMU: Kaohsiung Medical University)H-Index: 2
#2Cheng MjH-Index: 1
Last. Chen KpH-Index: 1
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AbstractPhytochemical investigation of the EtOAc-soluble fraction of the ethanolic extract of a yellow mutant of the fungus Monascus purpureus BCRC 38110 (Eurotiaceae) grown on rice resulted in the...
1 CitationsSource
#1Hsun-Shuo Chang (KMU: Kaohsiung Medical University)H-Index: 13
#2RS Chen (KMU: Kaohsiung Medical University)
Last. CH Lin (ITRI: Industrial Technology Research Institute)
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#1Ming-Jen ChengH-Index: 18
#2Ming-Der WuH-Index: 9
Last. Yueh-Hsiung KuoH-Index: 45
view all 7 authors...
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#1Ming-Der WuH-Index: 9
#2Ming-Jen ChengH-Index: 18
Last. Jih-Jung ChenH-Index: 25
view all 8 authors...
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#1Ming-Jen ChengH-Index: 18
#2Ming-Der WuH-Index: 9
Last. Yueh-Hsiung Kuo (PRC: China Medical University (PRC))H-Index: 45
view all 8 authors...
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#1Ho-Cheng Wu (KMU: Kaohsiung Medical University)H-Index: 2
#2Ming-Jen ChengH-Index: 18
Last. Hsun-Shuo Chang (KMU: Kaohsiung Medical University)H-Index: 13
view all 6 authors...
Abstract A chemical study on the EtOAc-soluble fraction of the 95% EtOH extract of red yeast rice fermented with the fungus Monascus purpureus BCRC 38110 (Eurotiaceae) has resulted in the isolation of three new compounds, i.e., two new 5′,6′-dihydrospiro[isochromane-1,2′-pyran]-4′(3′H)-one derivatives, designated as monascuspirolide A (1) and monascuspirolide B (2) and one benzenoid derivative, monapurpureusin B (3), together with three known compounds, monaspurpurone (4), monascin (5), and anka...
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#1Kuan-Ju Feng (KMU: Kaohsiung Medical University)H-Index: 1
#2Ming-Jen ChengH-Index: 18
Last. Hsun-Shuo Chang (KMU: Kaohsiung Medical University)H-Index: 13
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Fractionation of the BuOH-soluble fraction of the liquid fermentation of an endophytic fungus Ophiocordyceps sobolifer BCRC 38180 associated with the root of Taiwanese Ilex formosana (Aquifoliaceae) resulted in the isolation of one new diketopiperazine, soboliferamide (1), and one metabolite isolated for the first time from a natural source, cyclo-(Ile-Ser) (2), along with 18 previously identified compounds, 3–20. Their structures were elucidated by means of spectroscopic and mass-spectrometric ...
1 CitationsSource
#1Yu-Hsuan Wu (NCKU: National Cheng Kung University)H-Index: 3
#2Chin-Kai Tseng (NCKU: National Cheng Kung University)H-Index: 11
Last. Jin-Ching LeeH-Index: 20
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Dengue virus (DENV) caused millions of infections around the world annually. Co-infection with different serotypes of DENV is associated with dengue hemorrhagic shock syndrome, leading to an estimate of 50% death rate. No approved therapies are currently available for the treatment of DENV infection. Hence, novel anti-DENV agents are urgently needed for medical therapy. Here we demonstrated that a natural product (2 R,4 R)-1,2,4-trihydroxyheptadec-16-yne (THHY), extracted from avocado (Persea am...
1 CitationsSource
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