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Jane P. M. Ng
University of Technology, Sydney
3Publications
1H-index
4Citations
Publications 3
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#1Hui Chen (UTS: University of Technology, Sydney)H-Index: 24
#2Jane P. M. Ng (UTS: University of Technology, Sydney)H-Index: 1
Last.Stella M. Valenzuela (UTS: University of Technology, Sydney)H-Index: 28
view all 5 authors...
Background We have previously shown that intraperitoneal injection of gold nanoparticles (AuNPs, 20–30 nm) into mice, decreases high-fat diet (HFD) induced weight gain and glucose intolerance, via suppression of inflammatory responses in both fat and liver tissues. This study investigates whether AuNPs provide similar benefit to mice with pre-existing obesity. Male C57BL/6 mice were fed a HFD for 15 weeks. AuNPs (OB-EAu 0.0785 μg/g/day, OB-LAu 0.785 μg/g/day, OB-HAu7.85 μg/g/day, ip) were admini...
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#1Hui Chen (UTS: University of Technology, Sydney)H-Index: 24
#2Jane P. M. Ng (UTS: University of Technology, Sydney)H-Index: 1
Last.Stella M. Valenzuela (UTS: University of Technology, Sydney)H-Index: 28
view all 10 authors...
Obesity is a high risk for multiple metabolic disorders due to excessive influx of energy, glucose and lipid, often from a western based diet. Low-grade inflammation plays a key role in the progression of such metabolic disorders. The anti-inflammatory property of gold compounds has been used in treating rheumatoid arthritis in the clinic. Previously we found that pure gold nanoparticles (AuNPs, 21 nm) also possess anti-inflammatory effects on the retroperitoneal fat tissue following intraperito...
4 CitationsSource
#1Jane P. M. Ng (UTS: University of Technology, Sydney)H-Index: 1
#2Hui Chen (UTS: University of Technology, Sydney)H-Index: 24
Last.Stella M. Valenzuela (UTS: University of Technology, Sydney)H-Index: 28
view all 5 authors...
Objectives: Obesity is associated with chronic low grade inflammation. Adipose resident macrophages (ATMs) in obese individuals are known to produce increased levels of proinflammatory cytokines. We have previously shown that intraperitoneal (IP) injection of 20—30 nm gold nanoparticles (AuNPs) in lean mice can induce significant fat loss along with reduced adiposetissue-derived, tumour necrosis factor (TNF) mRNA expression without a concomitant change in ATM number. This study aimed to investig...
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