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Masafumi Yamamoto
Central Institute for Experimental Animals
GeneEndocrinologyEmbryonic stem cellMarmosetBiology
8Publications
3H-index
96Citations
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Publications 8
Newest
#1Hanako Morita (Central Institute for Experimental Animals)H-Index: 3
#2Masahiko Yasuda (Central Institute for Experimental Animals)H-Index: 6
Last. Nobuhito Hayashimoto (Central Institute for Experimental Animals)H-Index: 11
view all 7 authors...
: To investigate the prevalence of murine astrovirus (MuAstV) in mice in laboratory animal facilities in Japan, a polymerase chain reaction (PCR) test targeting the RNA-dependent RNA polymerase (RdRP) gene was performed on the cecum contents of 1,212 mice (1,183 immunocompetent mice and 29 immunodeficient mice) from 226 facilities. The results showed that 118 (52.2%) of the 226 facilities were positive for MuAstV. Out of the 1,212 mice, 424 (35.0%) were positive. No gross lesions were observed i...
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#1Sho Yoshimatsu (Keio: Keio University)H-Index: 3
#2Tsukika Sato (Keio: Keio University)H-Index: 1
Last. Hideyuki Okano (Keio: Keio University)H-Index: 114
view all 9 authors...
Abstract BLIMP1 (PRDM1) and VASA (DDX4) play pivotal roles in the development of the germ cell linage. Importantly, these genes are specifically expressed in germ cells; BLIMP1 in primordial germ cells (PGCs) to early-stage gonocytes, and VASA in migration-stage PGCs to mature gametes. The high reproductive efficiency of common marmosets (marmosets; Callithrix jacchus) makes them advantageous for use in germ cell research. We herein report the generation of a male marmoset embryonic stem cell (E...
1 CitationsSource
#1Haruo Hashimoto (Central Institute for Experimental Animals)H-Index: 7
#2Tomoo Eto (Central Institute for Experimental Animals)H-Index: 8
Last. Riichi Takahashi (Central Institute for Experimental Animals)H-Index: 5
view all 10 authors...
In Japan, it is possible to generate chimeric animals from specified embryos by combining animal blastocysts with human pluripotent stem (PS) cells (animal-human PS chimera). However, the production of animal-human PS chimeras has been restricted because of ethical concerns, such as the development of human-like intelligence and formation of humanized gametes in the animals, owing to the contributions of human PS cells to the brain and reproductive organs. To solve these problems, we established...
1 CitationsSource
#1Haruo Hashimoto (Central Institute for Experimental Animals)H-Index: 7
#2Masafumi Yamamoto (Central Institute for Experimental Animals)H-Index: 3
Last. Hiroshi Suemizu (Central Institute for Experimental Animals)H-Index: 24
view all 9 authors...
: Expression of peroxisome proliferator-activated receptor (PPAR) α was investigated in adiponectin knockout mice to elucidate the relationship between PPARα and adiponectin deficiency-induced diabetes. Adiponectin knockout (Adp-/-) mice were generated by gene targeting. Glucose tolerance test (GTT), insulin tolerance test (ITT), and organ sampling were performed in Adp-/- mice at the age of 10 weeks. PPARα, insulin, triglyceride, free fatty acid (FFA), and tumor necrosis factor α (TNFα) were an...
4 CitationsSource
#1Fumiko Seki (Central Institute for Experimental Animals)H-Index: 5
#2Keigo Hikishima (Central Institute for Experimental Animals)H-Index: 16
Last. Hideyuki Okano (Keio: Keio University)H-Index: 114
view all 10 authors...
Abstract Morphometry studies of human brain development have revealed characteristics of some growth patterns, such as gray matter (GM) and white matter (WM), but the features that make human neurodevelopment distinct from that in other species remain unclear. Studies of the common marmoset ( Callithrix jacchus ), a small New World primate, can provide insights into unique features such as cooperative behaviors complementary to those from comparative analyses using mouse and rhesus monkey. In th...
3 CitationsSource
#1Kenya Sato (Central Institute for Experimental Animals)H-Index: 3
#2Ryo Oiwa (Central Institute for Experimental Animals)H-Index: 5
Last. Erika Sasaki (Central Institute for Experimental Animals)H-Index: 21
view all 26 authors...
Recent advances in genome editing have facilitated the generation of nonhuman primate (NHP) models, with potential to unmask the complex biology of human disease not revealed by rodent models. However, their broader use is hindered by the challenges associated with generation of adult NHP models as well as the cost of their production. Here, we describe the generation of a marmoset model of severe combined immunodeficiency (SCID). This study optimized zinc-finger nucleases (ZFNs) and transcripti...
66 CitationsSource
#1Tsukasa Takahashi (Central Institute for Experimental Animals)H-Index: 1
#2Kisaburo Hanazawa (Juntendo University)H-Index: 11
Last. Erika Sasaki (Central Institute for Experimental Animals)H-Index: 21
view all 14 authors...
Intracytoplasmic sperm injection (ICSI), an important method used to treat male subfertility, is applied in the transgenic technology of sperm-mediated gene transfer. However, no study has described successful generation of offspring using ICSI in the common marmoset, a small non-human primate used as a model for biomedical translational research. In this study, we investigated blastocyst development and the subsequent live offspring stages of marmoset oocytes matured in vitro and fertilized by ...
19 CitationsSource
#1Yuichiro Higuchi (Central Institute for Experimental Animals)H-Index: 4
#2Kenji Kawai (Central Institute for Experimental Animals)H-Index: 19
Last. Hiroshi Suemizu (Central Institute for Experimental Animals)H-Index: 24
view all 8 authors...
The interaction between transplanted cells and host tissues is important for the growth and maintenance of transplanted cells. To analyze the mechanisms of these interactions, a systemic fluorescent protein-expressing mouse is a useful recipient. In this study, we generated a novel NOG strain, which strongly expresses enhanced green fluorescent protein (EGFP; PgkEGFP-NOG), especially in the liver, kidney, gastrointestinal tract, and testis. Because the host tissues expressed EGFP, xenotransplant...
2 CitationsSource
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