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Eunju Kang
Oregon National Primate Research Center
25Publications
13H-index
1,601Citations
Publications 25
Newest
Published on Mar 1, 2019in Nature43.07
Eunju Kang13
Estimated H-index: 13
(Oregon National Primate Research Center),
Jun Wu28
Estimated H-index: 28
(Salk Institute for Biological Studies)
+ 27 AuthorsYeonmi Lee6
Estimated H-index: 6
(Oregon National Primate Research Center)
Change history In this Letter, there are several errors regarding the assignments of mtDNA haplotypes for a subset of egg donors from our study. These errors have not been corrected online.
Published on Sep 11, 2018
Hong Ma27
Estimated H-index: 27
,
Nuria Marti-Gutierrez1
Estimated H-index: 1
+ 27 AuthorsRiffat Ahmed10
Estimated H-index: 10
Published on Jul 24, 2018in PLOS ONE2.78
Hong Ma27
Estimated H-index: 27
(Oregon National Primate Research Center),
Yeonmi Lee6
Estimated H-index: 6
(Oregon National Primate Research Center)
+ 12 AuthorsHayley Darby1
Estimated H-index: 1
(Oregon National Primate Research Center)
The accumulation of acquired mitochondrial genome (mtDNA) mutations with aging in somatic cells has been implicated in mitochondrial dysfunction and linked to age-onset diseases in humans. Here, we asked if somatic mtDNA mutations are also associated with aging in the mouse. MtDNA integrity in multiple organs and tissues in young and old (2–34 months) wild type (wt) mice was investigated by whole genome sequencing. Remarkably, no acquired somatic mutations were detected in tested tissues. Howeve...
Published on Aug 1, 2017in Nature43.07
Hong Ma27
Estimated H-index: 27
(Oregon National Primate Research Center),
Nuria Marti-Gutierrez1
Estimated H-index: 1
(OHSU: Oregon Health & Science University)
+ 28 AuthorsRiffat Ahmed10
Estimated H-index: 10
(OHSU: Oregon Health & Science University)
CRISPR–Cas9 genome editing is used to induce a DNA repair response and correct a disease-causing heterozygous mutation in human embryos with reduced mosaicism and preferential repair using the wild-type copy of the gene.
Published on Jan 1, 2017in Cell Stem Cell21.46
Hong Ma27
Estimated H-index: 27
(OHSU: Oregon Health & Science University),
Ryan C. O’Neil4
Estimated H-index: 4
(UCSD: University of California, San Diego)
+ 23 AuthorsYeonmi Lee6
Estimated H-index: 6
(OHSU: Oregon Health & Science University)
Summary Oocyte defects lie at the heart of some forms of infertility and could potentially be addressed therapeutically by alternative routes for oocyte formation. Here, we describe the generation of functional human oocytes following nuclear transfer of first polar body (PB1) genomes from metaphase II (MII) oocytes into enucleated donor MII cytoplasm (PBNT). The reconstructed oocytes supported the formation of de novo meiotic spindles and, after fertilization with sperm, meiosis completion and ...
Published on Jan 1, 2017in Stem Cells5.61
Don P. Wolf42
Estimated H-index: 42
,
Robert Morey9
Estimated H-index: 9
+ 4 AuthorsShoukhrat Mitalipov36
Estimated H-index: 36
Author(s): Wolf, Don P; Morey, Robert; Kang, Eunju; Ma, Hong; Hayama, Tomonari; Laurent, Louise C; Mitalipov, Shoukhrat | Abstract: Embryonic stem cells (ESC) hold promise for the treatment of human medical conditions but are allogeneic. Here, we consider the differences between autologous pluripotent stem cells produced by nuclear transfer (NT-ESCs) and transcription factor-mediated, induced pluripotent stem cells (iPSCs) that impact the desirability of each of these cell types for clinical use...
Published on Dec 1, 2016in Nature43.07
Eunju Kang13
Estimated H-index: 13
(UOU: University of Ulsan),
Jun Wu28
Estimated H-index: 28
(Salk Institute for Biological Studies)
+ 27 AuthorsYeonmi Lee6
Estimated H-index: 6
(OHSU: Oregon Health & Science University)
Analysis of mitochondrial replacement therapy shows, even with efficient mutant mitochondrial DNA replacement and maintenance in embryonic stem cells, a gradual loss of donor mitochondrial DNA in some lines owing to a polymorphism in the D-loop, potentially causing preferential replication of specific mitochondrial DNA haplotypes.
Published on Sep 10, 2016in Stem Cells5.61
Don P. Wolf42
Estimated H-index: 42
(OHSU: Oregon Health & Science University),
Robert Morey9
Estimated H-index: 9
(UCSD: University of California, San Diego)
+ 4 AuthorsShoukhrat Mitalipov36
Estimated H-index: 36
Published on Sep 1, 2016in Stem Cells5.61
Don P. Wolf42
Estimated H-index: 42
(Oregon National Primate Research Center),
Robert Morey9
Estimated H-index: 9
(UCSD: University of California, San Diego)
+ 4 AuthorsShoukhrat Mitalipov36
Estimated H-index: 36
(Oregon National Primate Research Center)
Embryonic stem cells (ESC) hold promise for the treatment of human medical conditions but are allogeneic. Here, we consider the differences between autologous pluripotent stem cells produced by nuclear transfer (NT-ESCs) and transcription factor-mediated, induced pluripotent stem cells (iPSCs) that impact the desirability of each of these cell types for clinical use. The derivation of NT-ESCs is more cumbersome and requires donor oocytes; however, the use of oocyte cytoplasm as the source of rep...
Published on Aug 1, 2016in Cell Metabolism22.41
Hong Ma27
Estimated H-index: 27
(Oregon National Primate Research Center),
Nuria Marti Gutierrez10
Estimated H-index: 10
(Oregon National Primate Research Center)
+ 9 AuthorsDon P. Wolf42
Estimated H-index: 42
(Oregon National Primate Research Center)
Vertebrate cells carry two different genomes, nuclear (nDNA) and mitochondrial (mtDNA), both encoding proteins involved in oxidative phosphorylation. Because of the extensive interactions, adaptive coevolution of the two genomes must occur to ensure normal mitochondrial function. To investigate whether incompatibilities between these two genomes could contribute to interspecies reproductive barriers, we performed reciprocal mtDNA replacement (MR) in zygotes between widely divergent Mus m. domest...
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