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Eunju Kang
Oregon National Primate Research Center
25Publications
13H-index
1,759Citations
Publications 25
Newest
#1Eunju Kang (Oregon National Primate Research Center)H-Index: 13
#2Jun Wu (Salk Institute for Biological Studies)H-Index: 29
Last.Shoukhrat MitalipovH-Index: 36
view all 30 authors...
Change history In this Letter, there are several errors regarding the assignments of mtDNA haplotypes for a subset of egg donors from our study. These errors have not been corrected online.
2 CitationsSource
#1Hong MaH-Index: 27
Last.Shoukhrat MitalipovH-Index: 36
view all 30 authors...
Source
#1Hong Ma (Oregon National Primate Research Center)H-Index: 27
#2Yeonmi Lee (Oregon National Primate Research Center)H-Index: 6
Last.Shoukhrat Mitalipov (Oregon National Primate Research Center)H-Index: 36
view all 15 authors...
The accumulation of acquired mitochondrial genome (mtDNA) mutations with aging in somatic cells has been implicated in mitochondrial dysfunction and linked to age-onset diseases in humans. Here, we asked if somatic mtDNA mutations are also associated with aging in the mouse. MtDNA integrity in multiple organs and tissues in young and old (2–34 months) wild type (wt) mice was investigated by whole genome sequencing. Remarkably, no acquired somatic mutations were detected in tested tissues. Howeve...
1 CitationsSource
#1Hong Ma (Oregon National Primate Research Center)H-Index: 27
#2Nuria Marti-Gutierrez (OHSU: Oregon Health & Science University)H-Index: 1
Last.Shoukhrat MitalipovH-Index: 36
view all 31 authors...
CRISPR–Cas9 genome editing is used to induce a DNA repair response and correct a disease-causing heterozygous mutation in human embryos with reduced mosaicism and preferential repair using the wild-type copy of the gene.
328 CitationsSource
#1Hong Ma (OHSU: Oregon Health & Science University)H-Index: 27
#2Ryan C. O’Neil (UCSD: University of California, San Diego)H-Index: 5
Last.Shoukhrat Mitalipov (OHSU: Oregon Health & Science University)H-Index: 36
view all 26 authors...
Summary Oocyte defects lie at the heart of some forms of infertility and could potentially be addressed therapeutically by alternative routes for oocyte formation. Here, we describe the generation of functional human oocytes following nuclear transfer of first polar body (PB1) genomes from metaphase II (MII) oocytes into enucleated donor MII cytoplasm (PBNT). The reconstructed oocytes supported the formation of de novo meiotic spindles and, after fertilization with sperm, meiosis completion and ...
25 CitationsSource
#1Don P. WolfH-Index: 42
#2Robert MoreyH-Index: 10
Last.Shoukhrat MitalipovH-Index: 36
view all 7 authors...
Author(s): Wolf, Don P; Morey, Robert; Kang, Eunju; Ma, Hong; Hayama, Tomonari; Laurent, Louise C; Mitalipov, Shoukhrat | Abstract: Embryonic stem cells (ESC) hold promise for the treatment of human medical conditions but are allogeneic. Here, we consider the differences between autologous pluripotent stem cells produced by nuclear transfer (NT-ESCs) and transcription factor-mediated, induced pluripotent stem cells (iPSCs) that impact the desirability of each of these cell types for clinical use...
10 CitationsSource
#1Eunju Kang (UOU: University of Ulsan)H-Index: 13
#2Jun Wu (Salk Institute for Biological Studies)H-Index: 29
Last.Shoukhrat MitalipovH-Index: 36
view all 30 authors...
Analysis of mitochondrial replacement therapy shows, even with efficient mutant mitochondrial DNA replacement and maintenance in embryonic stem cells, a gradual loss of donor mitochondrial DNA in some lines owing to a polymorphism in the D-loop, potentially causing preferential replication of specific mitochondrial DNA haplotypes.
89 CitationsSource
#1Don P. Wolf (OHSU: Oregon Health & Science University)H-Index: 42
#2Robert Morey (UCSD: University of California, San Diego)H-Index: 10
Last.Shoukhrat MitalipovH-Index: 36
view all 7 authors...
2 CitationsSource
#1Don P. Wolf (Oregon National Primate Research Center)H-Index: 42
#2Robert Morey (UCSD: University of California, San Diego)H-Index: 10
Last.Shoukhrat Mitalipov (Oregon National Primate Research Center)H-Index: 36
view all 7 authors...
Embryonic stem cells (ESC) hold promise for the treatment of human medical conditions but are allogeneic. Here, we consider the differences between autologous pluripotent stem cells produced by nuclear transfer (NT-ESCs) and transcription factor-mediated, induced pluripotent stem cells (iPSCs) that impact the desirability of each of these cell types for clinical use. The derivation of NT-ESCs is more cumbersome and requires donor oocytes; however, the use of oocyte cytoplasm as the source of rep...
Source
#1Hong Ma (Oregon National Primate Research Center)H-Index: 27
#2Nuria Marti Gutierrez (Oregon National Primate Research Center)H-Index: 10
Last.Shoukhrat Mitalipov (Oregon National Primate Research Center)H-Index: 36
view all 12 authors...
Vertebrate cells carry two different genomes, nuclear (nDNA) and mitochondrial (mtDNA), both encoding proteins involved in oxidative phosphorylation. Because of the extensive interactions, adaptive coevolution of the two genomes must occur to ensure normal mitochondrial function. To investigate whether incompatibilities between these two genomes could contribute to interspecies reproductive barriers, we performed reciprocal mtDNA replacement (MR) in zygotes between widely divergent Mus m. domest...
35 CitationsSource
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