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Jon Sin
Cedars-Sinai Medical Center
23Publications
7H-index
377Citations
Publications 23
Newest
#1Stefanie Marek-Iannucci (Cedars-Sinai Medical Center)
#2Amandine Thomas (Cedars-Sinai Medical Center)H-Index: 2
Last.Roberta A. Gottlieb (Cedars-Sinai Medical Center)H-Index: 64
view all 11 authors...
Animal studies have demonstrated beneficial effects of therapeutic hypothermia on myocardial function, yet exact mechanisms remain unclear. Impaired autophagy leads to heart failure and mitophagy is important for mitigating ischemia/reperfusion injury. This study aims to investigate whether the beneficial effects of therapeutic hypothermia are due to preserved autophagy and mitophagy. Under general anesthesia, the left anterior descending coronary artery of 19 female farm pigs was occluded for 9...
Source
#1Honit Piplani (Cedars-Sinai Medical Center)H-Index: 1
#2Stefanie Marek-Iannucci (Cedars-Sinai Medical Center)
Last.Stephen J. Pandol (Cedars-Sinai Medical Center)H-Index: 41
view all 17 authors...
Abstract Background During pancreatitis, autophagy is activated, but lysosomal degradation of dysfunctional organelles including mitochondria is impaired, resulting in acinar cell death. Retrospective cohort analyses demonstrated an association between simvastatin use and decreased acute pancreatitis incidence. Methods We examined whether simvastatin can protect cell death induced by cerulein and the mechanisms involved during acute pancreatitis. Mice were pretreated with DMSO or simvastatin (20...
Source
#1Mridula Ramesh (SDSU: San Diego State University)H-Index: 1
#2Juliane Cruz Campos (USP: University of São Paulo)H-Index: 11
Last.Allen M. Andres (Cedars-Sinai Medical Center)H-Index: 13
view all 11 authors...
The deleterious effects of statins on skeletal muscle are well known, but the mechanism associated with these effects remains unresolved. Statins are associated with mitochondrial damage, which may...
Source
#1Juliana Germano (Cedars-Sinai Medical Center)H-Index: 1
#2Savannah Sawaged (Cedars-Sinai Medical Center)H-Index: 1
Last.Jon Sin (Cedars-Sinai Medical Center)H-Index: 7
view all 7 authors...
Abstract Coxsackievirus B is a significant human pathogen and is a leading cause of myocarditis. We and others have observed that certain enteroviruses including coxsackievirus B cause infected cells to shed extracellular vesicles containing infectious virus. Recent reports have shown that vesicle-bound virus can infect more efficiently than free virus. Though microRNAs are differentially regulated in cells following infection, few have been associated with the vesicles shed from infected cells....
2 CitationsSource
#1Umut Inci Onat (Bilkent University)H-Index: 3
#2Asli D. YildirimH-Index: 2
Last.Ebru ErbayH-Index: 12
view all 14 authors...
Abstract Background Eukaryotic cells can respond to diverse stimuli by converging at serine-51 phosphorylation on eukaryotic initiation factor 2 alpha (eIF2α) and activate the integrated stress response (ISR). This is a key step in translational control and must be tightly regulated; however, persistent eIF2α phosphorylation is observed in mouse and human atheroma. Objectives Potent ISR inhibitors that modulate neurodegenerative disorders have been identified. Here, the authors evaluated the pot...
5 CitationsSource
#1Harry H. MatundanH-Index: 1
#2Jon SinH-Index: 7
Last.Moshe ArditiH-Index: 34
view all 10 authors...
1 CitationsSource
#1Honit Piplani (Cedars-Sinai Medical Center)H-Index: 1
#2Ankush Sharma (EUR: Erasmus University Rotterdam)H-Index: 5
Last.Roberta A. Gottlieb (Cedars-Sinai Medical Center)H-Index: 64
view all 8 authors...
Source
#1Allen M. Andres (Cedars-Sinai Medical Center)H-Index: 13
#2Juliana Germano (Cedars-Sinai Medical Center)H-Index: 1
Last.Robert M. Mentzer (Cedars-Sinai Medical Center)H-Index: 48
view all 8 authors...
Source
#1Juliana Germano (Cedars-Sinai Medical Center)H-Index: 1
#2Chengqun Huang (Cedars-Sinai Medical Center)H-Index: 13
Last.Allen M. Andres (Cedars-Sinai Medical Center)H-Index: 13
view all 7 authors...
Source
#1Allen M. Andres (Cedars-Sinai Medical Center)H-Index: 13
#2Juliana Germano (Cedars-Sinai Medical Center)H-Index: 1
Last.Robert M. Mentzer (Cedars-Sinai Medical Center)H-Index: 48
view all 8 authors...
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