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Jon Sin
Cedars-Sinai Medical Center
20Publications
7H-index
307Citations
Publications 20
Newest
Published on Dec 1, 2019in Scientific Reports 4.01
S. Marek-Iannucci (Cedars-Sinai Medical Center), Amandine Thomas2
Estimated H-index: 2
(Cedars-Sinai Medical Center)
+ 8 AuthorsAllen M. Andres11
Estimated H-index: 11
(Cedars-Sinai Medical Center)
Animal studies have demonstrated beneficial effects of therapeutic hypothermia on myocardial function, yet exact mechanisms remain unclear. Impaired autophagy leads to heart failure and mitophagy is important for mitigating ischemia/reperfusion injury. This study aims to investigate whether the beneficial effects of therapeutic hypothermia are due to preserved autophagy and mitophagy. Under general anesthesia, the left anterior descending coronary artery of 19 female farm pigs was occluded for 9...
Honit Piplani1
Estimated H-index: 1
(Cedars-Sinai Medical Center),
S. Marek-Iannucci (Cedars-Sinai Medical Center)+ -3 AuthorsYang Song (Cedars-Sinai Medical Center)
Abstract Background During pancreatitis, autophagy is activated, but lysosomal degradation of dysfunctional organelles including mitochondria is impaired, resulting in acinar cell death. Retrospective cohort analyses demonstrated an association between simvastatin use and decreased acute pancreatitis incidence. Methods We examined whether simvastatin can protect cell death induced by cerulein and the mechanisms involved during acute pancreatitis. Mice were pretreated with DMSO or simvastatin (20...
Published in The FASEB Journal 5.39
Mridula Ramesh (SDSU: San Diego State University), Juliane C. Campos11
Estimated H-index: 11
(USP: University of São Paulo)
+ -3 AuthorsJulio C. B. Ferriera (USP: University of São Paulo)
The deleterious effects of statins on skeletal muscle are well known, but the mechanism associated with these effects remains unresolved. Statins are associated with mitochondrial damage, which may...
Published on Mar 1, 2019in Virology 2.66
Juliana Germano (Cedars-Sinai Medical Center), Savannah Sawaged (Cedars-Sinai Medical Center)+ 4 AuthorsJon Sin7
Estimated H-index: 7
(Cedars-Sinai Medical Center)
Abstract Coxsackievirus B is a significant human pathogen and is a leading cause of myocarditis. We and others have observed that certain enteroviruses including coxsackievirus B cause infected cells to shed extracellular vesicles containing infectious virus. Recent reports have shown that vesicle-bound virus can infect more efficiently than free virus. Though microRNAs are differentially regulated in cells following infection, few have been associated with the vesicles shed from infected cells....
Published on Mar 1, 2019in Journal of the American College of Cardiology 18.64
Umut I. Onat2
Estimated H-index: 2
(Bilkent University),
Asli D. Yıldırım2
Estimated H-index: 2
+ 11 AuthorsJon Sin7
Estimated H-index: 7
(Cedars-Sinai Medical Center)
Abstract Background Eukaryotic cells can respond to diverse stimuli by converging at serine-51 phosphorylation on eukaryotic initiation factor 2 alpha (eIF2α) and activate the integrated stress response (ISR). This is a key step in translational control and must be tightly regulated; however, persistent eIF2α phosphorylation is observed in mouse and human atheroma. Objectives Potent ISR inhibitors that modulate neurodegenerative disorders have been identified. Here, the authors evaluated the pot...
Published on Aug 3, 2018in Circulation Research 15.86
Allen M. Andres11
Estimated H-index: 11
(Cedars-Sinai Medical Center),
Juliana Germano (Cedars-Sinai Medical Center)+ 5 AuthorsRobert M Mentzer2
Estimated H-index: 2
(Cedars-Sinai Medical Center)
Published on Aug 3, 2018in Circulation Research 15.86
Honit Piplani1
Estimated H-index: 1
(Cedars-Sinai Medical Center),
Ankush Sharma (EUR: Erasmus University Rotterdam)+ 5 AuthorsRoberta A. Gottlieb63
Estimated H-index: 63
(Cedars-Sinai Medical Center)
Published on Aug 3, 2018in Circulation Research 15.86
Allen M. Andres11
Estimated H-index: 11
(Cedars-Sinai Medical Center),
Juliana Germano (Cedars-Sinai Medical Center)+ 5 AuthorsRobert M Mentzer2
Estimated H-index: 2
(Cedars-Sinai Medical Center)
Published on Aug 3, 2018in Circulation Research 15.86
Juliana Germano (Cedars-Sinai Medical Center), Chengqun Huang13
Estimated H-index: 13
(Cedars-Sinai Medical Center)
+ 4 AuthorsAllen M. Andres11
Estimated H-index: 11
(Cedars-Sinai Medical Center)
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