Claude Bouchard
Pennington Biomedical Research Center
EndocrinologyObesityDiabetes mellitusMedicineBiology
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Publications 1221
#1Venkatesh L. Murthy (UM: University of Michigan)H-Index: 33
#2Rui Xia (University of Texas Health Science Center at Houston)H-Index: 1
Last. Ravi V. Shah (Harvard University)H-Index: 39
view all 12 authors...
Importance Obesity is a major determinant of disease burden worldwide. Polygenic risk scores (PRSs) have been posited as key predictors of obesity. How a PRS can be translated to the clinical encounter (especially in the context of fitness, activity, and parental history of overweight) remains unclear. Objective To quantify the relative importance of a PRS, fitness, activity, parental history of overweight, and body mass index (BMI) (calculated as weight in kilograms divided by height in meters ...
#2Mika Kivimaeki (UCL: University College London)H-Index: 122
Last. Nicholas J. Wareham (University of Cambridge)H-Index: 169
view all 21 authors...
Proteins are effector molecules that mediate the functions of genes1,2 and modulate comorbidities3–10, behaviors and drug treatments11. They represent an enormous potential resource for personalized, systemic and data-driven diagnosis, prevention, monitoring and treatment. However, the concept of using plasma proteins for individualized health assessment across many health conditions simultaneously has not been tested. Here, we show that plasma protein expression patterns strongly encode for mul...
2 CitationsSource
#1Jordi Merino (Broad Institute)H-Index: 11
#2Hassan S. Dashti (Broad Institute)H-Index: 13
Last. Toshiko Tanaka (NIH: National Institutes of Health)H-Index: 73
view all 106 authors...
Macronutrient intake, the proportion of calories consumed from carbohydrate, fat, and protein, is an important risk factor for metabolic diseases with significant familial aggregation. Previous studies have identified two genetic loci for macronutrient intake, but incomplete coverage of genetic variation and modest sample sizes have hindered the discovery of additional loci. Here, we expanded the genetic landscape of macronutrient intake, identifying 12 suggestively significant loci (P < 1 × 10−...
6 CitationsSource
#1Raymond Noordam (LUMC: Leiden University Medical Center)H-Index: 14
#2Maxime M. Bos (LUMC: Leiden University Medical Center)H-Index: 1
Last. Susan Redline (Brigham and Women's Hospital)H-Index: 111
view all 148 authors...
Both short and long sleep are associated with an adverse lipid profile, likely through different biological pathways. To elucidate the biology of sleep-associated adverse lipid profile, we conduct multi-ancestry genome-wide sleep-SNP interaction analyses on three lipid traits (HDL-c, LDL-c and triglycerides). In the total study sample (discovery + replication) of 126,926 individuals from 5 different ancestry groups, when considering either long or short total sleep time interactions in joint ana...
2 CitationsSource
#1Robin G Walters (University of Oxford)H-Index: 3
#1David W. Clark (Edin.: University of Edinburgh)H-Index: 6
Last. James F. Wilson (Edin.: University of Edinburgh)H-Index: 107
view all 436 authors...
In many species, the offspring of related parents suffer reduced reproductive success, a phenomenon known as inbreeding depression. In humans, the importance of this effect has remained unclear, partly because reproduction between close relatives is both rare and frequently associated with confounding social factors. Here, using genomic inbreeding coefficients (FROH) for >1.4 million individuals, we show that FROH is significantly associated (p < 0.0005) with apparently deleterious changes in 32...
1 CitationsSource
#1Juan de Toro-Martín (Laval University)H-Index: 3
#2Frédéric Guénard (Laval University)H-Index: 13
Last. Marie-Claude Vohl (Laval University)H-Index: 46
view all 6 authors...
Background and aims. Obesity is a major health problem worldwide. Given the heterogeneous obesity phenotype, an optimal obesity stratification would improve clinical management. Since obesity has a strong genetic component, we aimed to develop a polygenic risk score (PRS) to stratify obesity according to the genetic background of the individuals. Methods. A total of 231 single nucleotide polymorphisms (SNP) significantly associated to body mass index (BMI) from 21 genome-wide association studies...
#1Robert Ross (UM: University of Michigan)H-Index: 51
#2Bret H. Goodpaster (Translational Research Institute)H-Index: 81
Last. Claude Bouchard (Pennington Biomedical Research Center)H-Index: 136
view all 16 authors...
There is evidence from human twin and family studies as well as mouse and rat selection experiments that there are considerable interindividual differences in the response of cardiorespiratory fitness (CRF) and other cardiometabolic traits to a given exercise programme dose. We developed this consensus statement on exercise response variability following a symposium dedicated to this topic. There is strong evidence from both animal and human studies that exercise training doses lead to variable ...
5 CitationsSource
#1Yun J. Sung (WashU: Washington University in St. Louis)H-Index: 7
#2L de Las Fuentes (WashU: Washington University in St. Louis)H-Index: 2
Last. Alanna C. Morrison (University of Texas Health Science Center at Houston)H-Index: 44
view all 279 authors...
U.S. National Heart, Lung, and Blood Institute (NHLBI) (K25HL121091 to Y.J.S.); National Institutes of Health (R01HL118305).
2 CitationsSource