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Mollie N. Carruthers
Harvard University
20Publications
15H-index
3,068Citations
Publications 20
Newest
Published on Sep 1, 2016in The Journal of Allergy and Clinical Immunology
Hamid Mattoo16
Estimated H-index: 16
(Harvard University),
Vinay S. Mahajan20
Estimated H-index: 20
(Harvard University)
+ 11 AuthorsMollie N. Carruthers15
Estimated H-index: 15
(Harvard University)
Background IgG 4 -related disease (IgG 4 -RD) is a systemic condition of unknown cause characterized by highly fibrotic lesions with dense lymphoplasmacytic infiltrates. CD4 + T cells constitute the major inflammatory cell population in IgG 4 -RD lesions. Objective We used an unbiased approach to characterize CD4 + T-cell subsets in patients with IgG 4 -RD based on their clonal expansion and ability to infiltrate affected tissue sites. Methods We used flow cytometry to identify CD4 + effector/me...
Published on Sep 1, 2016in Arthritis Care and Research4.53
Xavier Jimenez (HUP: Hospital of the University of Pennsylvania), Sarah P. Psutka14
Estimated H-index: 14
(Mayo Clinic)
+ 1 AuthorsMollie N. Carruthers15
Estimated H-index: 15
(Harvard University)
Published on Dec 1, 2015in Annals of the Rheumatic Diseases14.30
Emanuel Della-Torre13
Estimated H-index: 13
(Harvard University),
Eoin R. Feeney13
Estimated H-index: 13
(Harvard University)
+ 8 AuthorsShiv Pillai45
Estimated H-index: 45
(Harvard University)
Objectives Fibrosis is a predominant feature of IgG4-related disease (IgG4-RD). B-cell depletion induces a prompt clinical and immunological response in patients with IgG4-RD, but the effects of this intervention on fibrosis in IgG4-RD are unknown. We used the enhanced liver fibrosis (ELF) score to address the impact of rituximab on fibroblast activation. The ELF score is an algorithm based on serum concentrations of procollagen-III aminoterminal propeptide, tissue inhibitor of matrix metallopro...
Published on Aug 1, 2015in Annals of the Rheumatic Diseases14.30
John H. Stone67
Estimated H-index: 67
(Harvard University),
Mollie N. Carruthers15
Estimated H-index: 15
(Harvard University)
+ 7 AuthorsSuresh T. Chari73
Estimated H-index: 73
(Mayo Clinic)
We thank Yamamoto and colleagues1 for their response to our paper2 and their description of their experience with rituximab (RTX) in IgG4-related disease (IgG4-RD) in three patients. Their letter raises a number of important points pertaining to the management of IgG4-RD, in general, and to the use of B-cell-depletion strategies, specifically. First, their patients are exemplary of the fact a sizeable subset of IgG4-RD patients has a propensity to disease relapse over time. This point has been u...
Published on Jun 1, 2015in Annals of the Rheumatic Diseases14.30
Mollie N. Carruthers15
Estimated H-index: 15
(Harvard University),
Topazian1
Estimated H-index: 1
(Mayo Clinic)
+ 7 AuthorsJohn H. Stone67
Estimated H-index: 67
(Harvard University)
Objectives To evaluate the efficacy of rituximab (RTX) in IgG4-related disease (IgG4-RD) in an open-label pilot trial. Methods We treated 30 IgG4-RD patients with two doses of RTX (1000 mg each). The participants were either treated with RTX alone (n = 26; 87%) or required to discontinue baseline glucocorticoids (GC) within 2 months (n = 4; 13%). Disease activity was measured by the IgG4-RD Responder Index (IgG4-RD RI) and physician9s global assessment (PGA). Disease response was defined as the ...
Published on Jan 1, 2015in Annals of the Rheumatic Diseases14.30
Mollie N. Carruthers15
Estimated H-index: 15
(Harvard University),
Arezou Khosroshahi25
Estimated H-index: 25
(Emory University)
+ 2 AuthorsJohn H. Stone67
Estimated H-index: 67
(Harvard University)
Objectives We evaluated the sensitivity, specificity and positive and negative predictive values of elevated serum IgG4 concentrations for the diagnosis of IgG4-RD. Methods Between 2001 and 2011, 190 unique patients had elevated serum IgG4 measurements. We reviewed electronic medical records to determine the indication for IgG4 measurement and underlying clinical diagnosis. Additionally, we reviewed the records of 190 other randomly selected patients from a pool of 3360 with normal results, to e...
Published on Jan 1, 2015in Annals of the Rheumatic Diseases14.30
Zachary S. Wallace17
Estimated H-index: 17
(Harvard University),
Hamid Mattoo16
Estimated H-index: 16
(Harvard University)
+ 7 AuthorsJohn H. Stone67
Estimated H-index: 67
(Harvard University)
Objectives We examined the utility of circulating total and IgG4+ plasmablasts as biomarkers of diagnosis and disease activity in IgG4-related disease (IgG4-RD). Materials methods We evaluated patients with active, untreated, biopsy-proven IgG4-RD affecting various organs. Flow cytometry was used to measure total plasmablast and IgG4+ plasmablast counts by gating peripheral blood for CD19lowCD38+CD20−CD27+ cells and CD19lowCD38+CD20−CD27+IgG4+ cells. Serum IgG4 concentrations were measured by ne...
Published on Nov 4, 2014in Seminars in Neurology1.47
Robert Carruthers5
Estimated H-index: 5
(Brigham and Women's Hospital),
Mollie N. Carruthers15
Estimated H-index: 15
(Harvard University),
Emanuel Della-Torre13
Estimated H-index: 13
Immunoglobulin-4 (IgG4-) related disease is a newly described treatable condition that has recently expanded the differential diagnosis of inflammatory meningeal disorders. This review will discuss the main clinical and pathophysiological features of IgG4-related meningeal disease in the context of meningeal inflammatory disorders in general. Particular attention will be dedicated to the differential diagnosis and the different therapeutic approaches.
Published on Sep 1, 2014in The Journal of Allergy and Clinical Immunology
Hamid Mattoo16
Estimated H-index: 16
(Harvard University),
Vinay S. Mahajan20
Estimated H-index: 20
(Harvard University)
+ 6 AuthorsShiv Pillai45
Estimated H-index: 45
(Harvard University)
Background IgG 4 -related disease (IgG 4 -RD) is a poorly understood, multiorgan, chronic inflammatory disease characterized by tumefactive lesions, storiform fibrosis, obliterative phlebitis, and accumulation of IgG 4 -expressing plasma cells at disease sites. Objective The role of B cells and IgG 4 antibodies in IgG 4 -RD pathogenesis is not well defined. We evaluated patients with IgG 4 -RD for activated B cells in both disease lesions and peripheral blood and investigated their role in disea...
Published on Aug 28, 2014
Hamid Mattoo16
Estimated H-index: 16
,
Vinay Mahajan1
Estimated H-index: 1
+ 6 AuthorsShiv Pillai45
Estimated H-index: 45
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