Luca Prevedello
University of Padua
Sleeve gastrectomyWeight lossDiabetes mellitusGeneral surgeryMedicine
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Publications 34
#1Emanuele Luigi Carniel (UNIPD: University of Padua)H-Index: 21
#2Alice Albanese (UNIPD: University of Padua)H-Index: 6
Last. Mirto Foletto (UNIPD: University of Padua)H-Index: 33
view all 9 authors...
Abstract Even though bariatric surgery is one of the most effective treatment option of obesity, post-surgical weight loss is not always ensured, especially in the long term, when many patients experience weight regain. Bariatric procedures are largely based on surgeon's expertise and intra-operative decisions, while an integrated in-silico approach could support surgical activity. The effects of bariatric surgery on gastric distension, which activates the neural circuitry promoting satiety, can...
#1Mirto Foletto (UNIPD: University of Padua)H-Index: 33
#2Alice Albanese (UNIPD: University of Padua)H-Index: 6
Last. Luca Prevedello (UNIPD: University of Padua)H-Index: 9
view all 3 authors...
Bariatric restrictive procedures induce weight loss by limiting food and calorie intake. This group of procedures is heterogeneous as far as the surgical technique. The consequent anatomical modifications may cause different potential complications. The complications of restrictive procedures need to be properly recognized and addressed, given the high number of patients treated in the past that may require conversion from previous bariatric procedures (vertical banded gastroplasty or gastric ba...
#1Silvia Bettini (UNIPD: University of Padua)H-Index: 3
#2Francesca Favaretto (UNIPD: University of Padua)H-Index: 8
Last. Luca Busetto (UNIPD: University of Padua)H-Index: 38
view all 13 authors...
Determinants of resting energy expenditure (REE) in humans are still under investigation, especially the association with insulin resistance. Brown adipose tissue (AT) regulates energy expenditure through the activity of the uncoupling protein 1 (UCP1). White AT browning is the process by which some adipocytes within AT depots acquire properties of brown adipocytes (“brite” adipocytes) and it correlates with metabolic improvement. We analyzed determinants of REE in patients with obesity and asse...
3 CitationsSource
#1Anna Belligoli (UNIPD: University of Padua)H-Index: 5
#2Chiara Compagnin (UNIPD: University of Padua)H-Index: 9
Last. Roberto Vettor (UNIPD: University of Padua)H-Index: 49
view all 19 authors...
Although obesity represents a risk factor for the development of type 2 diabetes mellitus (T2DM), the link between these pathological conditions is not so clear. The manner in which the different elements of adipose tissue (AT) interplay in order to grow has been suggested to have a role in the genesis of metabolic complications, but this has not yet been fully addressed in humans. Through IHC, transmission electron microscopy, cytometry, and in vitro cultures, we described the morphological and...
2 CitationsSource
#1Alice Zoso (UNIPD: University of Padua)H-Index: 5
#2Alessandro Zambon (UNIPD: University of Padua)H-Index: 9
Last. Nicola ElvassoreH-Index: 36
view all 8 authors...
: Systemic diseases affect multiple tissues that interact with each other within a network difficult to explore at the body level. However, understanding the interdependences between tissues could be of high relevance for drug target identification, especially at the first stages of disease development. In vitro systems have the advantages of accessibility to measurements and precise controllability of culture conditions, but currently have limitations in mimicking human in vivo systemic tissue ...
#1Silvia BettiniH-Index: 3
#2Emanuel BordigatoH-Index: 1
Last. Roberto FabrisH-Index: 14
view all 14 authors...
Background: Non-alcoholic fatty liver disease (NAFLD) has a high prevalence in obesity and its presence should be screened. Laparoscopic sleeve gastrectomy (LSG) is an effective treatment for obesity, but its effects on NAFLD are still to be firmly established. The diagnosis of non-alcoholic steatohepatitis (NASH) is currently performed by liver biopsy, a costly and invasive procedure. Squamous cell carcinoma antigen-IgM (SCCA-IgM) is a biomarker of viral hepatitis to hepatocellular carcinoma de...
#1Alice Albanese (UNIPD: University of Padua)H-Index: 6
#2Luca Prevedello (UNIPD: University of Padua)H-Index: 9
Last. Mirto Foletto (UNIPD: University of Padua)H-Index: 33
view all 6 authors...
Background Pre-operative diet may play an important role as far as patients’ fitness for surgery, post-operative outcomes, and successful weight loss. Our aim was to compare surgical outcome and weight loss in two groups of patients who were offered two different pre-operative kinds of diet: very low calorie diet (VLCD) and very low calorie ketogenic diet (VLCKD).
4 CitationsSource
#1Silvia Bettini (UNIPD: University of Padua)H-Index: 3
#2Emanuel Bordigato (UNIPD: University of Padua)H-Index: 1
Last. Luca Busetto (UNIPD: University of Padua)H-Index: 38
view all 13 authors...
Objectives Resting energy expenditure (REE) declines more than what is expected according to body composition changes after caloric restriction. This metabolic adaptation is considered one of the factors favoring weight regain. The aim of this study is to evaluate the changes of REE and calculate the degree of metabolic adaptation occurring after laparoscopic sleeve gastrectomy (LSG).
9 CitationsSource
#1Christian Borgo (UNIPD: University of Padua)H-Index: 8
#2Gabriella Milan (UNIPD: University of Padua)H-Index: 24
Last. Roberto Vettor (UNIPD: University of Padua)H-Index: 49
view all 15 authors...
Insulin plays a major role in glucose metabolism and insulin-signaling defects are present in obesity and diabetes. CK2 is a pleiotropic protein kinase implicated in fundamental cellular pathways and abnormally elevated in tumors. Here we report that in human and murine adipocytes CK2-inhibition decreases the insulin-induced glucose-uptake by counteracting Akt-signaling and GLUT4-translocation to the plasma membrane. In mice CK2 acts on insulin-signaling in adipose tissue, liver and skeletal mus...
7 CitationsSource