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S. Bruzzì
University of Eastern Piedmont
20Publications
5H-index
74Citations
Publications 20
Newest
#1Salvatore SuttiH-Index: 14
#2S. BruzzìH-Index: 5
Last.Frank TackeH-Index: 66
view all 10 authors...
Recent evidence suggests that hepatic dendritic cells (HDCs) contribute to the evolution of chronic liver diseases. However, the HDC subsets involved and the mechanisms driving these responses are still poorly understood. In this study, we have investigated the role of the fractalkine receptor CX3CR1 in modulating monocyte-derived dendritic cell (moDC) differentiation during liver inflammation. The phenotype of HDC and functional relevance of CX3CR1 was assessed in mice following necro-inflammat...
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#1B. FogliaH-Index: 2
#2Salvatore SuttiH-Index: 14
Last.Maurizio ParolaH-Index: 50
view all 14 authors...
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#1S. BruzzìH-Index: 5
#2Salvatore SuttiH-Index: 14
Last.Emanuele AlbanoH-Index: 43
view all 12 authors...
Abstract Recent evidence implicates adaptive immunity as a key player in the mechanisms supporting hepatic inflammation during the progression of nonalcoholic fatty liver disease (NAFLD). In these settings, patients with NAFLD often show an increase in the circulating levels of antibodies against oxidative stress-derived epitopes (OSE). Nonetheless, the actual role of humoral immunity in NAFLD is still unclear. This study investigates the contribution of B-lymphocytes to NAFLD evolution. B-lymph...
2 CitationsSource
#1E. MorelloH-Index: 5
#2Salvatore SuttiH-Index: 14
Last.Maurizio ParolaH-Index: 50
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Mechanisms underlying progression of non-alcoholic fatty liver disease (NAFLD) are still incompletely characterized. Hypoxia and hypoxia inducible factors (HIFs) have been implicated in the pathogenesis of chronic liver diseases but the actual role of HIF-2α in the evolution of NAFLD has never been investigated in detail. In this study, we show that HIF-2α is selectively overexpressed in the cytosol and the nuclei of hepatocytes in a very high percentage (> 90%) of liver biopsies from a cohort o...
10 CitationsSource
#1S. SuttiH-Index: 1
#2S. BruzzìH-Index: 5
Last.Emanuele AlbanoH-Index: 43
view all 9 authors...
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#1Salvatore Sutti (University of Eastern Piedmont)H-Index: 14
#2Felix HeymannH-Index: 23
Last.Frank TackeH-Index: 66
view all 7 authors...
The chemokine fractalkine (C–X3–C motif chemokine ligand 1, CX 3 CL1) and its receptor (C–X3–C motif chemokine receptor 1, CX 3 CR1) are known to mediate leukocyte chemotaxis, adhesion, and survival. In the liver, CX 3 CR1 is expressed on multiple cell types including monocytes and dendritic cells. However, the function of CX 3 CR1 on hepatic dendritic cells (HDCs) is still poorly understood. In the present study, we investigated the role of CX 3 CR1 on mouse HDCs during homeostasis and followin...
3 CitationsSource
#2Santina QuartaH-Index: 14
Last.Patrizia PontissoH-Index: 45
view all 14 authors...
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#1E. Morello (UNITO: University of Turin)H-Index: 5
#2Salvatore Sutti (UNITO: University of Turin)
Last.Maurizio Parola (UNITO: University of Turin)H-Index: 50
view all 10 authors...
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#1S. BruzzìH-Index: 5
#2Salvatore SuttiH-Index: 14
Last.Emanuele AlbanoH-Index: 43
view all 9 authors...
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#1S. BruzzìH-Index: 5
#2S. SuttiH-Index: 1
Last.Emanuele AlbanoH-Index: 43
view all 8 authors...
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