Daniel J. Rader
University of Pennsylvania
Publications 1172
#1Henry R. Kranzler (UPenn: University of Pennsylvania)H-Index: 85
#2Hang Zhou (Yale University)H-Index: 6
Last.Joel Gelernter (Yale University)H-Index: 89
view all 20 authors...
The original version of this Article omitted the following from the Acknowledgements: ‘Supported by the Mental Illness Research, Education and Clinical Center of the Veterans Integrated Service Network 4 of the Department of Veterans Affairs.’ This has now been corrected in both the PDF and HTML versions of the Article.
#1Juan M. Banda (Stanford University)H-Index: 14
#2Ashish Sarraju (Cardiovascular Institute of the South)H-Index: 4
Last.Joshua W. Knowles (Cardiovascular Institute of the South)H-Index: 42
view all 18 authors...
Familial hypercholesterolemia (FH) is an underdiagnosed dominant genetic condition affecting approximately 0.4% of the population and has up to a 20-fold increased risk of coronary artery disease if untreated. Simple screening strategies have false positive rates greater than 95%. As part of the FH Foundation′s FIND FH initiative, we developed a classifier to identify potential FH patients using electronic health record (EHR) data at Stanford Health Care. We trained a random forest classifier us...
3 CitationsSource
#1Sarah J. Schrauben (UPenn: University of Pennsylvania)H-Index: 3
#2Christopher Jepson (UPenn: University of Pennsylvania)H-Index: 34
Last.Harold I. Feldman (UPenn: University of Pennsylvania)H-Index: 67
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Insulin resistance contributes to the metabolic syndrome, which is associated with the development of kidney disease. However, it is unclear if insulin resistance independently contributes to an increased risk of chronic kidney disease (CKD) progression or CKD complications. Additionally, predisposing factors responsible for insulin resistance in the absence of diabetes in CKD are not well described. This study aimed to describe factors associated with insulin resistance and characterize the rel...
#1Henry R. Kranzler (UPenn: University of Pennsylvania)H-Index: 85
#2Hang Zhou (Yale University)H-Index: 6
Last.Joel Gelernter (Yale University)H-Index: 89
view all 20 authors...
Alcohol consumption level and alcohol use disorder (AUD) diagnosis are moderately heritable traits. We conduct genome-wide association studies of these traits using longitudinal Alcohol Use Disorder Identification Test-Consumption (AUDIT-C) scores and AUD diagnoses in a multi-ancestry Million Veteran Program sample (N = 274,424). We identify 18 genome-wide significant loci: 5 associated with both traits, 8 associated with AUDIT-C only, and 5 associated with AUD diagnosis only. Polygenic Risk Sco...
13 CitationsSource
#1Dirk Müller-Wieland (RWTH Aachen University)H-Index: 30
#2Daniel J. Rader (UPenn: University of Pennsylvania)H-Index: 137
Last.Eli M. Roth (UC: University of Cincinnati)H-Index: 20
view all 10 authors...
#1Joseph Park (UPenn: University of Pennsylvania)H-Index: 1
#2KatzNathan (UPenn: University of Pennsylvania)H-Index: 6
Last.Daniel J. Rader (UPenn: University of Pennsylvania)H-Index: 137
view all 11 authors...
Background: By coupling large-scale DNA sequencing with electronic health records (EHR), "genome-first" approaches can enhance our understanding of the contribution of rare genetic variants to disease. Aggregating rare, loss-of-function variants in a candidate gene into a "gene burden" to test for association with EHR phenotypes can identify both known and novel clinical implications for the gene in human disease. However, this methodology has not yet been applied on both an exome-wide and pheno...
#1Sarah McCarron (UPenn: University of Pennsylvania)
#2Brooke Bathon (UPenn: University of Pennsylvania)
Last.Tobias Raabe (UPenn: University of Pennsylvania)H-Index: 11
view all 8 authors...
To determine if patient liver derived organoids can in principle be a useful experimental model for non alcoholic staetohepatitis (NASH), we derived to our knowledge for the first time bipotent ductal organoids from endstage NASH patient livers, and for comparison from normal donor livers. We found that all tested NASH liver derived organoids exhibited a profound failure to dedifferentiate from the hepatic state back to the biliary state, consistent with the known poor regenerative capacity of N...
#1Jessica Johnston (University of Sheffield)H-Index: 2
#2Adrienn Angyal (University of Sheffield)H-Index: 5
Last.Endre Kiss-Toth (University of Sheffield)H-Index: 24
view all 15 authors...
Macrophages drive atherosclerotic plaque progression and rupture; hence, attenuating their atherosclerosis-inducing properties holds promise for reducing coronary heart disease (CHD). Recent studies in mouse models have demonstrated that Tribbles 1 (Trib1) regulates macrophage phenotype and shows that Trib1 deficiency increases plasma cholesterol and triglyceride levels, suggesting that reduced TRIB1 expression mediates the strong genetic association between the TRIB1 locus and increased CHD ris...
#1Daniel J. Rader (UPenn: University of Pennsylvania)H-Index: 137