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Catherine Aude-Garcia
Centre national de la recherche scientifique
Molecular biologyOxidative stressGlutathioneBiochemistryBiology
21Publications
12H-index
403Citations
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Publications 22
Newest
Iron oxide nanoparticles/microparticles are widely present in a variety of environments, e.g., as a byproduct of steel and iron degradation, as, for example, in railway brakes (e.g., metro station) or in welding fumes. As all particulate material, these metallic nanoparticles are taken up by macrophages, a cell type playing a key role in the innate immune response, including pathogen removal phagocytosis, secretion of free radical species such as nitric oxide or by controlling inflammation via c...
1 CitationsSource
#1Bastien Dalzon (CNRS: Centre national de la recherche scientifique)H-Index: 2
#2Anaëlle Torres (CNRS: Centre national de la recherche scientifique)
Last. Thierry Rabilloud (CNRS: Centre national de la recherche scientifique)H-Index: 43
view all 12 authors...
Silver nanoparticles are known to strongly affect biological systems, and numerous toxicological studies have investigated their effects. Most of these studies examine the effects immediately following acute exposure. In this work, we have conducted further investigation by studying not only the acute, post-exposure response, but also the cellular response after a 72 hour-recovery-phase post exposure. As a biological model we have used macrophages, which are very important cells with respect to ...
Source
#1Joanna BonsH-Index: 1
#2Charlotte MacronH-Index: 3
Last. Thierry RabilloudH-Index: 43
view all 8 authors...
All but thirteen mammalian mitochondrial proteins are encoded by the nuclear genome, translated in the cytosol and then imported into the mitochondria. For a significant proportion of the mitochondrial proteins, import is coupled with the cleavage of a presequence called the transit peptide, and the formation of a new N-terminus. Determination of the neo N-termini has been investigated by proteomic approaches in several systems, but generally in a static way to compile as many N-termini as possi...
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#1Bastien Dalzon (CNRS: Centre national de la recherche scientifique)H-Index: 2
#2Mélanie Guidetti (UGA: University of Grenoble)H-Index: 1
Last. Catherine Aude-Garcia (CNRS: Centre national de la recherche scientifique)H-Index: 12
view all 15 authors...
Many solid tumors and their metastases are still resistant to current cancer treatments such as chemo- and radiotherapy. The presence of a small population of Cancer Stem Cells in tumors is held responsible for relapses. Moreover, the various physical barriers of the organism (e.g. blood–brain barrier) prevent many drugs from reaching the target cells. In order to alleviate this constraint, we suggest a Trojan horse strategy consisting of intravascular injection of macrophages loaded with therap...
1 CitationsSource
#1Djadidi Toybou (CNRS: Centre national de la recherche scientifique)H-Index: 1
#2Caroline CelleH-Index: 16
Last. Jean-Pierre SimonatoH-Index: 23
view all 5 authors...
Correction for ‘A toxicology-informed, safer by design approach for the fabrication of transparent electrodes based on silver nanowires’ by Djadidi Toybou et al., Environ. Sci.: Nano, 2019, DOI: 10.1039/c8en00890f.
4 CitationsSource
#1Bastien Dalzon (CNRS: Centre national de la recherche scientifique)H-Index: 2
#2Catherine Aude-Garcia (CNRS: Centre national de la recherche scientifique)H-Index: 12
Last. Thierry Rabilloud (CNRS: Centre national de la recherche scientifique)H-Index: 43
view all 11 authors...
The technological and economic benefits of engineered nanomaterials may be offset by their adverse effects on living organisms. One of the highly produced nanomaterials under such scrutiny is amorphous silica nanoparticles, which are known to have an appreciable, although reversible, inflammatory potential. This is due to their selective toxicity toward macrophages, and it is thus important to study the cellular responses of this cell type to silica nanoparticles to better understand the direct ...
10 CitationsSource
#1Catherine Aude-Garcia (CNRS: Centre national de la recherche scientifique)H-Index: 12
#2Florent Villiers (CNRS: Centre national de la recherche scientifique)H-Index: 2
Last. Thierry Rabilloud (CNRS: Centre national de la recherche scientifique)H-Index: 43
view all 11 authors...
Silver nanoparticles (Ag-NPs) are used in a variety of consumers' goods. Their toxicological impact is currently intensely studied, mostly upon acute exposure, but their intracellular dissolution and fate is rather poorly documented. In this study, murine primary macrophages were exposed to a single high but non-lethal dose of Ag-NPs or to repeated, low doses of Ag-NPs. Cells were either collected immediately after acute exposure or after 72 h of recovery in the NP-free exposure medium. Ag intra...
14 CitationsSource
#1Catherine Aude-Garcia (CNRS: Centre national de la recherche scientifique)H-Index: 12
#2Bastien Dalzon (CNRS: Centre national de la recherche scientifique)H-Index: 2
Last. Thierry Rabilloud (CNRS: Centre national de la recherche scientifique)H-Index: 43
view all 10 authors...
The cellular responses of the J774 macrophage cell line to zinc oxide and zirconium oxide nanoparticles have been studied by a comparative quantitative, protein level based proteomic approach. The most prominent results have been validated by targeted approaches. These approaches have been carried out under culture conditions that stimulate mildly the aryl hydrocarbon receptor, thereby mimicking conditions that can be encountered in vivo in complex environments. The comparative approach with two...
21 CitationsSource
#1Sarah TribouletH-Index: 4
#2Catherine Aude-Garcia (CNRS: Centre national de la recherche scientifique)H-Index: 12
Last. Thierry Rabilloud (CNRS: Centre national de la recherche scientifique)H-Index: 43
view all 14 authors...
Titanium dioxide and copper oxide nanoparticles are more and more widely used because of their catalytic properties, of their light absorbing properties (titanium dioxide) or of their biocidal properties (copper oxide), increasing the risk of adverse health effects. In this frame, the responses of mouse macrophages were studied. Both proteomic and targeted analyses were performed to investigate several parameters, such as phagocytic capacity, cytokine release, copper release, and response at sub...
32 CitationsSource
#1Giulia Veronesi (Biomet)H-Index: 18
#2Catherine Aude-Garcia (CNRS: Centre national de la recherche scientifique)H-Index: 12
Last. Marie CarrièreH-Index: 32
view all 8 authors...
Silver nanoparticle (AgNP) toxicity is related to their dissolution in biological environments and to the binding of the released Ag+ ions in cellulo; the chemical environment of recombined Ag+ ions is responsible for their toxicological outcome, moreover it is indicative of the cellular response to AgNP exposure, and can therefore shed light on the mechanisms governing AgNP toxicity. This study probes the chemistry of Ag species in primary murine macrophages exposed to AgNPs by making use of X-...
21 CitationsSource
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