Isabelle Lemieux
Laval University
Publications 130
#1Anne Gangloff (Laval University)H-Index: 8
#2Jean Bergeron (Laval University)H-Index: 50
Last.Jean-Pierre Després (Laval University)H-Index: 118
view all 7 authors...
Obesity has been associated with elevated leptinemia and vitamin D deficiency. To date, whether there is an association between vitamin D and leptin levels independent from adiposity remains uncertain. Our objective was to investigate the associations between changes in 25(OH) vitamin D levels, changes in adiposity variables, and changes in leptin levels produced by a 1-year lifestyle intervention program. Sedentary men (n = 113) with abdominal obesity, dyslipidemic, and non-vitamin D supplement...
1 CitationsSource
#1Sophie Carter (Laval University)H-Index: 7
#2Isabelle Lemieux (Laval University)H-Index: 46
Last.Frédéric Picard (Laval University)H-Index: 22
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Abstract Background and aims Recent transversal studies have associated insulin-like growth factor binding protein (IGFBP)-2 levels with glucose tolerance and parameters of the lipoprotein-lipid profile. Here, we aimed at determining the longitudinal effects of a one-year lifestyle modification program on IGFBP-2 levels and to identify specific metabolic improvements impacted by the changes in IGFBP-2. Methods 99 middle-aged Caucasian men were involved in a lifestyle modification program consist...
#1A. Maltais (Laval University)H-Index: 3
#2Natalie Alméras (Laval University)H-Index: 40
Last.Jean-Pierre Després (Laval University)H-Index: 118
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Abstract Background/objectives Thigh muscle attenuation measured by computed tomography (CT) has been shown to be a reliable and useful index of skeletal muscle fat infiltration. Thigh muscle fat content assessed by CT has been linked to obesity and type 2 diabetes and is a correlate of insulin resistance in sedentary individuals. However, as measurement of mid-thigh fat content requires the assessment of another region of interest beyond the usual abdominal scan required to measure levels of vi...
1 CitationsSource
#1Marie-Ève Piché (Laval University)H-Index: 15
#2Paul Poirier (Laval University)H-Index: 55
Last.Jean-Pierre Després (Laval University)H-Index: 118
view all 4 authors...
Abstract Obesity is recognized as a heterogeneous condition in which individuals with similar body mass index may have distinct metabolic and cardiovascular risk profiles. Susceptibility to obesity-related cardiometabolic complications is not solely mediated by overall body fat mass, but is largely dependent upon individual differences in regional body fat distribution and ability of subcutaneous adipose tissue to expand. The present review will discuss to what extent the individual variation in...
44 CitationsSource
#1Stephanie LeBlanc (Laval University)H-Index: 1
#2François Coulombe (Laval University)H-Index: 4
Last.Eric Larose (Laval University)H-Index: 37
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Background Subclinical atherosclerosis identification remains challenging; abdominal visceral adiposity may improve risk stratification beyond traditional cardiovascular risk factors. Hypertriglyceridemic waist, a visceral adiposity marker combining elevated triglycerides (≥2 mmol/L) and waist circumference (≥90 cm), has been related to carotid atherosclerosis, although associations with high‐risk features, including lipid‐rich necrotic core (LRNC), remain unknown. We tested the hypothesis that ...
4 CitationsSource
#1Isabelle LemieuxH-Index: 46
#2Charles CouillardH-Index: 34
Last.Jean-Pierre DespresH-Index: 3
view all 6 authors...
11 Citations
Purpose of review Low vitamin D levels have been extensively reported in obesity. Thus, the pandemic of obesity has been paralleled by a high prevalence of low vitamin D status. Given the well documented associations linking poor vitamin D status to adverse health outcomes (diabetes, cardiovascular disease, cancers, all-cause mortality), a proper understanding of the mechanisms linking excess adiposity to low vitamin D status is key to identify and implement effective interventions to replenish ...
9 CitationsSource
#1Anne GangloffH-Index: 8
#2Jean BergeronH-Index: 50
Last.Jean-Pierre DesprésH-Index: 118
view all 7 authors...