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Jennie Chan
University of Massachusetts Medical School
14Publications
10H-index
625Citations
Publications 14
Newest
#1Roland Elling (University of Freiburg)H-Index: 6
#2Elektra K. Robinson (UCSC: University of California, Santa Cruz)H-Index: 3
Last.Susan Carpenter (UCSC: University of California, Santa Cruz)H-Index: 18
view all 18 authors...
Summary An inducible gene expression program is a hallmark of the host inflammatory response. Recently, long intergenic non-coding RNAs (lincRNAs) have been shown to regulate the magnitude, duration, and resolution of these responses. Among these is lincRNA-Cox2 , a dynamically regulated gene that broadly controls immune gene expression. To evaluate the in vivo functions of this lincRNA, we characterized multiple models of lincRNA-Cox2 -deficient mice. LincRNA-Cox2 -deficient macrophages and mur...
10 CitationsSource
#1Shrutie Sharma (UMMS: University of Massachusetts Medical School)H-Index: 14
#2Allison M. Campbell (Yale University)H-Index: 5
Last.Katherine A. Fitzgerald (UMMS: University of Massachusetts Medical School)H-Index: 95
view all 13 authors...
Background Cytosolic DNA-sensing pathways that signal via the adaptor Stimulator of Interferon Genes (STING) mediate immunity to pathogens and have also been known to promote autoimmune pathology in DNAseII/III-deficient mice. However, the role of these pathways in systemic models of autoimmunity is unexplored. We hypothesised that cytosolic DNA sensing pathways contribute to the pathogenesis of autoimmune disease. Surprisingly, we report here that STING potently suppresses inflammation in sever...
Source
#1Roland Elling (UMMS: University of Massachusetts Medical School)H-Index: 6
#2Jennie Chan (UMMS: University of Massachusetts Medical School)H-Index: 10
Last.Katherine A. Fitzgerald (UMMS: University of Massachusetts Medical School)H-Index: 95
view all 3 authors...
The innate immune system represents the first line of defense during infection and is initiated by the detection of conserved microbial products by germline-encoded pattern recognition receptors (PRRs). Sensing through PRRs induces broad transcriptional changes that elicit powerful inflammatory responses. Tight regulation of these processes depends on multiple regulatory checkpoints, including noncoding RNA species such as microRNAs. In addition, long noncoding RNAs (lncRNAs) have recently gaine...
32 CitationsSource
#1Guy Surpris (Tufts University)H-Index: 2
#2Jennie Chan (UMMS: University of Massachusetts Medical School)H-Index: 10
Last.Alexander PoltorakH-Index: 18
view all 11 authors...
With the stimulator of IFN genes (STING) C terminus being extensively studied, the role of the N-terminal domain (NTD) of STING remains an important subject of investigation. In this article, we identify novel mutations in NTD of Sting of the MOLF strain in response to HSV and Listeria monocytogenes both in vitro and in vivo. These mutations are responsible for low levels of IFN-β caused by failure of MOLF STING to translocate from the endoplasmic reticulum. These data provide evidence that the ...
10 CitationsSource
#1Jennie Chan (UMMS: University of Massachusetts Medical School)H-Index: 10
#2Maninjay K. Atianand (UMMS: University of Massachusetts Medical School)H-Index: 13
Last.Daniel R. Caffrey (UMMS: University of Massachusetts Medical School)H-Index: 21
view all 8 authors...
Natural antisense transcripts (NATs) are a class of long noncoding RNAs (lncRNAs) that are complementary to other protein-coding genes. Although thousands of NATs are encoded by mammalian genomes, their functions in innate immunity are unknown. In this study, we identified and characterized a novel NAT, AS-IL1α, which is partially complementary to IL-1α. Similar to IL-1α, AS-IL1α is expressed at low levels in resting macrophages and is induced following infection with Listeria monocytogenes or s...
43 CitationsSource
#1Shrutie SharmaH-Index: 14
#2Allison M. Campbell (Yale University)H-Index: 5
Last.Katherine A. Fitzgerald (NTNU: Norwegian University of Science and Technology)H-Index: 95
view all 13 authors...
Cytosolic DNA-sensing pathways that signal via Stimulator of interferon genes (STING) mediate immunity to pathogens and also promote autoimmune pathology in DNaseII- and DNaseIII-deficient mice. In contrast, we report here that STING potently suppresses inflammation in a model of systemic lupus erythematosus (SLE). Lymphoid hypertrophy, autoantibody production, serum cytokine levels, and other indicators of immune activation were markedly increased in STING-deficient autoimmune-prone mice compar...
64 CitationsSource
#1Jennie ChanH-Index: 10
Last.Daniel R. CaffreyH-Index: 21
view all 8 authors...
39 CitationsSource
#1Rahul Gupta (UMMS: University of Massachusetts Medical School)H-Index: 3
#2Shubhendu Ghosh (UMMS: University of Massachusetts Medical School)H-Index: 7
Last.Douglas T. Golenbock (UMMS: University of Massachusetts Medical School)H-Index: 110
view all 19 authors...
The inflammatory cytokine IL-1β is critical for host responses against many human pathogens. Here, we define Group B Streptococcus (GBS)-mediated activation of the Nod-like receptor-P3 (NLRP3) inflammasome in macrophages. NLRP3 activation requires GBS expression of the cytolytic toxin, β-hemolysin, lysosomal acidification, and leakage. These processes allow the interaction of GBS RNA with cytosolic NLRP3. The present study supports a model in which GBS RNA, along with lysosomal components includ...
34 CitationsSource
#1Rahul GuptaH-Index: 3
#2Rahul GuptaH-Index: 3
Last.Douglas T. GolenbockH-Index: 1
view all 19 authors...
The inflammatory cytokine IL-1β is critical for host responses against many human pathogens. Here, we define Group B Streptococcus (GBS)-mediated activation of the Nod-like receptor-P3 (NLRP3) inflammasome in macrophages. NLRP3 activation requires GBS expression of the cytolytic toxin, β-hemolysin, lysosomal acidification, and leakage. These processes allow the interaction of GBS RNA with cytosolic NLRP3. The present study supports a model in which GBS RNA, along with lysosomal components includ...
#1Peter Liehl (University of Lisbon)H-Index: 6
#2Vanessa Zuzarte-Luis (University of Lisbon)H-Index: 11
Last.Maria M. Mota (University of Lisbon)H-Index: 45
view all 26 authors...
After mosquito bite, the malaria parasite first infects the liver, where it is thought to be undetected by the host immune system as it develops into the blood-stage pathogen. Maria Mota and her colleagues now report that Plasmodium RNA is detected by hepatocytes, triggering an interferon response that controls the parasite burden in the liver and blood of infected mice.
131 CitationsSource
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