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Tara L. Roberts
University of New South Wales
Molecular biologyImmunologyCancer researchDNABiology
57Publications
14H-index
1,566Citations
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Publications 59
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Glioblastoma (GBM) is the most common form of primary brain cancer in adults and tissue biopsies for diagnostic purposes are often inaccessible. The postulated idea that brain cancer cells cannot pass the blood–brain barrier to form circulating tumor cells (CTCs) has recently been overthrown and CTCs have been detected in the blood of GBM patients albeit in low numbers. Given the potential of CTCs to be analyzed for GBM biomarkers that may guide therapy decisions it is important to define method...
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#1Bashar Thejer (University of Wasit)H-Index: 1
#2Partho P. Adhikary (UBC: University of British Columbia)H-Index: 3
Last. Perlita Poh (ANU: Australian National University)H-Index: 1
view all 31 authors...
BACKGROUND: Progesterone Receptor Membrane Component 1 (PGRMC1) is expressed in many cancer cells, where it is associated with detrimental patient outcomes. It contains phosphorylated tyrosines which evolutionarily preceded deuterostome gastrulation and tissue differentiation mechanisms. RESULTS: We demonstrate that manipulating PGRMC1 phosphorylation status in MIA PaCa-2 (MP) cells imposes broad pleiotropic effects. Relative to parental cells over-expressing hemagglutinin-tagged wild-type (WT) ...
4 CitationsSource
The DNA damage response enables cells to survive and maintain genome integrity. RAD52 is a DNA-binding protein involved in the homologous recombination in DNA repair, and is important for the maintenance of tumour genome integrity. We investigated possible correlations between RAD52 expression and cancer survival and response to preoperative radiotherapy. RAD52 expression was examined in tumour samples from 179 patients who underwent surgery for rectal cancer, including a sub-cohort of 40 patien...
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#1Marra Jai Aghajani (USYD: University of Sydney)H-Index: 2
#2Adam Cooper (USYD: University of Sydney)H-Index: 5
Last. Tara L. Roberts (UNSW: University of New South Wales)H-Index: 14
view all 11 authors...
Blockade of the PD-1/PD-L1 pathway with targeted monoclonal antibodies has demonstrated encouraging anti-tumour activity in multiple cancer types. We present the case of a patient with BRAF-negative stage IVC anaplastic thyroid cancer (ATC) treated with the anti-PD-1 monoclonal antibody, pembrolizumab, following radiographic progression on chemoradiation. Blood samples were collected prior to and at four time points during treatment with pembrolizumab. Mass cytometry was used to determine expres...
1 CitationsSource
#1Uda Ho (UQ: University of Queensland)H-Index: 4
#2John Luff (UQ: University of Queensland)H-Index: 3
Last. Tara L. Roberts (UNSW: University of New South Wales)H-Index: 14
view all 10 authors...
Suppressor of morphogenesis in genitalia 1 (SMG1) and ataxia telangiectasia mutated (ATM) are members of the PI3-kinase like-kinase (PIKK) family of proteins. ATM is a well-established tumour suppressor. Loss of one or both alleles of ATM results in an increased risk of cancer development, particularly haematopoietic cancer and breast cancer in both humans and mouse models. In mice, total loss of SMG1 is embryonic lethal and loss of a single allele results in an increased rate of cancer developm...
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#1Yi Chieh Lim (QIMR: QIMR Berghofer Medical Research Institute)H-Index: 11
#2Kathleen S. Ensbey (QIMR: QIMR Berghofer Medical Research Institute)H-Index: 8
Last. Bryan W. Day (QUT: Queensland University of Technology)H-Index: 17
view all 26 authors...
1 CitationsSource
#1Bashar Thejer (CSU: Charles Sturt University)H-Index: 1
#2Partho P. Adhikary (CSU: Charles Sturt University)H-Index: 1
Last. Michael A. Cahill (CSU: Charles Sturt University)H-Index: 25
view all 31 authors...
Background: Progesterone Receptor Membrane Component 1 (PGRMC1) is expressed in many cancer cells, where it is associated with detrimental patient outcomes. Multiple different functions and cellular locations have been attributed to PGRMC1 in a variety of contexts, however the mechanisms underlying PGRMC1 biology remain obscure. The protein contains several phosphorylated residues including tyrosines which were acquired in animal evolution prior to bilateral symmetry, and could be involved with ...
3 CitationsSource
#1Pei N. DingH-Index: 2
#2Therese M. Becker (UNSW: University of New South Wales)H-Index: 21
Last. Tara L. Roberts (UNSW: University of New South Wales)H-Index: 14
view all 9 authors...
Background Gene mutation analysis from plasma circulating tumor DNA (ctDNA) can provide timely information regarding the mechanism of resistance that could translate to personalised treatment. We compared concordance rate of next generation sequencing (NGS) and droplet digital polymerase chain reaction (ddPCR) in the detection of the EGFR activating and T790M mutation from plasma ctDNA with diagnostic tissue biopsy‐based assays. The second objective was to test whether putative osimertinib resis...
1 CitationsSource
#1Pei N. DingH-Index: 2
#2Therese M. Becker (UNSW: University of New South Wales)H-Index: 21
Last. Tara L. Roberts (UNSW: University of New South Wales)H-Index: 14
view all 11 authors...
Abstract Objective To determine the predictive and prognostic roles of three blood-based biomarkers: circulating tumour DNA (ctDNA), circulating tumour cells (CTC) and carcinoembryonic antigen (CEA), in patients with advanced epidermal growth factor receptor-mutated (EGFR+) lung cancer. Materials and methods We recruited 28 patients with 103 serial blood samples. We performed mutational analyses for EGFR mutations using droplet digital PCR (ddPCR) on ctDNA. We evaluated the accuracy of EGFR muta...
1 CitationsSource
#1Marra Jai Aghajani (USYD: University of Sydney)H-Index: 2
#2Tara L. Roberts (USYD: University of Sydney)H-Index: 14
Last. Navin NilesH-Index: 3
view all 7 authors...
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