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Afonso C. Silva
National Institutes of Health
112Publications
35H-index
3,038Citations
Publications 112
Newest
#1Cirong Liu (NIH: National Institutes of Health)H-Index: 1
#2Cecil Chern-Chyi Yen (NIH: National Institutes of Health)H-Index: 6
Last.Afonso C. Silva (NIH: National Institutes of Health)H-Index: 35
view all 6 authors...
The default mode network (DMN) is associated with a wide range of brain functions. In humans, the DMN is marked by strong functional connectivity among three core regions: medial prefrontal cortex (mPFC), posterior parietal cortex (PPC), and the medial parietal and posterior cingulate cortex (PCC). Neuroimaging studies have shown that the DMN also exists in non-human primates, suggesting that it may be a conserved feature of the primate brain. Here, we found that, in common marmosets, the dorsol...
#1Jennifer Lefeuvre (NIH: National Institutes of Health)H-Index: 2
#2Joseph R. Guy (NIH: National Institutes of Health)H-Index: 3
Last.S. Lehericy (University of Paris)H-Index: 4
view all 11 authors...
Background:Experimental autoimmune encephalomyelitis (EAE) in the common marmoset is a nonhuman primate model of multiple sclerosis (MS) that shares numerous clinical, radiological, and pathological features with MS. Among the clinical features are motor and sensory deficits that are highly suggestive of spinal cord (SC) damage.Objective:To characterize the extent and nature of SC damage in symptomatic marmosets with EAE using a combined magnetic resonance imaging (MRI) and histopathology approa...
#1Emily Leibovitch (NIH: National Institutes of Health)H-Index: 8
#2Breanna Caruso (NIH: National Institutes of Health)H-Index: 5
Last.Pascal Sati (NIH: National Institutes of Health)H-Index: 17
view all 13 authors...
Pathogens, particularly human herpesviruses (HHVs), are implicated as triggers of disease onset/progression in multiple sclerosis (MS) and other neuroinflammatory disorders. However, the time between viral acquisition in childhood and disease onset in adulthood complicates the study of this association. Using nonhuman primates, we demonstrate that intranasal inoculations with HHV-6A and HHV-6B accelerate an MS-like neuroinflammatory disease, experimental autoimmune encephalomyelitis (EAE). Altho...
#1Nathanael J. Lee (NIH: National Institutes of Health)H-Index: 2
#2Seung-Kwon Ha (NIH: National Institutes of Health)H-Index: 2
Last.Mark A. Petersen (UCSF: University of California, San Francisco)H-Index: 7
view all 14 authors...
#1Cirong Liu (NIH: National Institutes of Health)H-Index: 1
#2Frank Q. Ye (NIH: National Institutes of Health)H-Index: 31
Last.Afonso C. Silva (NIH: National Institutes of Health)H-Index: 35
view all 7 authors...
Abstract The common marmoset ( Callithrix jacchus ) is a New-World monkey of growing interest in neuroscience. Magnetic resonance imaging (MRI) is an essential tool to unveil the anatomical and functional organization of the marmoset brain. To facilitate identification of regions of interest, it is desirable to register MR images to an atlas of the brain. However, currently available atlases of the marmoset brain are mainly based on 2D histological data, which are difficult to apply to 3D imagin...
#1Sang-Ho ChoiH-Index: 11
#2Allison L. AraiH-Index: 1
Last.Afonso C. SilvaH-Index: 35
view all 7 authors...
Background and Purpose— MAGL (monoacylglycerol lipase) is an enzyme that hydrolyzes the endocannabinoid 2-arachidonoylglycerol and regulates the production of arachidonic acid and prostaglandins—substances that mediate tissue inflammatory response. Here, we have studied the effects of the selective MAGL inhibitors JZL184 and MJN110 and their underlying molecular mechanisms on 3 different experimental models of focal cerebral ischemia. Methods— SHR (spontaneously hypertensive rats) and normotensi...
#1Yoshiyuki Hirano (NIH: National Institutes of Health)H-Index: 15
#2Cecil Chern-Chyi Yen (NIH: National Institutes of Health)H-Index: 6
Last.Afonso C. Silva (NIH: National Institutes of Health)H-Index: 35
view all 8 authors...
#1Cecil Chern-Chyi Yen (NIH: National Institutes of Health)H-Index: 6
#2Daniel Papoti (NIH: National Institutes of Health)H-Index: 5
Last.Afonso C. Silva (NIH: National Institutes of Health)H-Index: 35
view all 3 authors...
Abstract Blood oxygenation level dependent (BOLD) functional magnetic resonance imaging (fMRI) has become a major tool to map neural activity. However, the spatiotemporal characteristics of the BOLD functional hemodynamic response across the cortical layers remain poorly understood. While human fMRI studies suffer from low spatiotemporal resolution, the use of anesthesia in animal models introduces confounding factors. Additionally, inflow contributions to the fMRI signal become non-negligible w...
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