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Pan-Jun Kim
Pohang University of Science and Technology
40Publications
13H-index
859Citations
Publications 40
Newest
#1Hang-Hyun Jo (Aalto University)
#2Yeon Jeong Kim (OSU: Ohio State University)
Last.Pan-Jun KimH-Index: 13
view all 6 authors...
Circadian clocks play a pivotal role in orchestrating numerous physiological and developmental events. Waveform shapes of the oscillations of protein abundances can be informative about the underlying biochemical processes of circadian clocks. We derive a mathematical framework where waveforms do reveal hidden biochemical mechanisms of circadian timekeeping. We find that the cost of synthesizing proteins with particular waveforms can be substantially reduced by rhythmic protein half-lives over t...
#1Seunghyeon Kim (ICTP: International Centre for Theoretical Physics)H-Index: 3
#2Michael FenechH-Index: 56
Last.Pan-Jun KimH-Index: 13
view all 3 authors...
Diet design for vegetarian health is challenging due to the limited food repertoire of vegetarians. This challenge can be partially overcome by quantitative, data-driven approaches that utilise massive nutritional information collected for many different foods. Based on large-scale data of foods’ nutrient compositions, the recent concept of nutritional fitness helps quantify a nutrient balance within each food with regard to satisfying daily nutritional requirements. Nutritional fitness offers p...
#1Jaeyun Sung (Broad Institute)H-Index: 8
#2Seunghyeon Kim (ICTP: International Centre for Theoretical Physics)H-Index: 3
Last.Pan-Jun Kim (POSTECH: Pohang University of Science and Technology)H-Index: 13
view all 8 authors...
The metabolic interactions between gut microbes and host cells play roles in human health. Here, Sung et al. present a literature-curated metabolic network of the human gut microbiota and three human cell types, together with a mathematical approach to identify distinct microbial and metabolic features in gut microbiomes.
#1Jaeyun Sung (Asia Pacific Center for Theoretical Physics)H-Index: 8
#2Vanessa L. Hale (Mayo Clinic)H-Index: 7
Last.Nicholas Chia (UR: University of Rochester)H-Index: 22
view all 5 authors...
The recent advances in high-throughput omics technologies have enabled researchers to explore the intricacies of the human microbiome. On the clinical front, the gut microbial community has been the focus of many biomarker-discovery studies. While the recent deluge of high-throughput data in microbiome research has been vastly informative and groundbreaking, we have yet to capture the full potential of omics-based approaches. Realizing the promise of multi-omics data will require integration of ...
#1Yujin LeeH-Index: 2
#2Wooseon HwangH-Index: 5
Last.Seung-Jae LeeH-Index: 45
view all 7 authors...
Genetic studies using model organisms have shown that many long-lived mutants display impaired fitness, such as reduced fecundity and delayed development. However, in several wild animals, the association between longevity and fitness does not seem to be inevitable. Thus, the relationship between longevity and fitness in wild organisms remains inconclusive. Here, we determined the correlation between lifespan and fitness, developmental rate and brood size, by using 16 wild-derived C. elegans str...
#1Jun Seob Kim (SKKU: Sungkyunkwan University)H-Index: 1
#2Da Hyeong Cho (SKKU: Sungkyunkwan University)H-Index: 2
Last.Dae-Hee Lee (Korea Research Institute of Bioscience and Biotechnology)H-Index: 17
view all 15 authors...
ABSTRACT Bacterial persisters are a small fraction of quiescent cells that survive in the presence of lethal concentrations of antibiotics. They can regrow to give rise to a new population that has the same vulnerability to the antibiotics as did the parental population. Although formation of bacterial persisters in the presence of various antibiotics has been documented, the molecular mechanisms by which these persisters tolerate the antibiotics are still controversial. We found that amplificat...
#1Mathias Foo (Warw.: University of Warwick)H-Index: 7
#2David E. Somers (OSU: Ohio State University)H-Index: 35
Last.Pan-Jun Kim (POSTECH: Pohang University of Science and Technology)H-Index: 13
view all 3 authors...
A wide range of organisms features molecular machines, circadian clocks, which generate endogenous oscillations with ~24 h periodicity and thereby synchronize biological processes to diurnal environmental fluctuations. Recently, it has become clear that plants harbor more complex gene regulatory circuits within the core circadian clocks than other organisms, inspiring a fundamental question: are all these regulatory interactions between clock genes equally crucial for the establishment and maint...
#1Seunghyeon Kim (POSTECH: Pohang University of Science and Technology)H-Index: 3
#2Jaeyun Sung (Asia Pacific Center for Theoretical Physics)H-Index: 8
Last.Pan-Jun Kim (POSTECH: Pohang University of Science and Technology)H-Index: 13
view all 5 authors...
Recent progresses in data-driven analysis methods, including network-based approaches, are revolutionizing many classical disciplines. These techniques can also be applied to food and nutrition, which must be studied to design healthy diets. Using nutritional information from over 1,000 raw foods, we systematically evaluated the nutrient composition of each food in regards to satisfying daily nutritional requirements. The nutrient balance of a food was quantified and termed nutritional fitness; ...
#1Jinhyuk Yun (KAIST)H-Index: 2
#2Pan-Jun Kim (POSTECH: Pohang University of Science and Technology)H-Index: 13
Last.Hawoong Jeong (KAIST)H-Index: 38
view all 3 authors...
The quest for historically impactful science and technology provides invaluable insight into the innovation dynamics of human society, yet many studies are limited to qualitative and small-scale approaches. Here, we investigate scientific evolution through systematic analysis of a massive corpus of digitized English texts between 1800 and 2008. Our analysis reveals great predictability for long-prevailing scientific concepts based on the levels of their prior usage. Interestingly, once a thresho...
#1Mathias Foo (Asia Pacific Center for Theoretical Physics)H-Index: 7
#2David E. Somers (OSU: Ohio State University)H-Index: 35
Last.Pan-Jun Kim (POSTECH: Pohang University of Science and Technology)H-Index: 13
view all 3 authors...
The circadian system generates an endogenous oscillatory rhythm that governs the daily activities of organisms in nature. It offers adaptive advantages to organisms through a coordination of their biological functions with the optimal time of day. In this paper, a model of the circadian system in the plant Arabidopsis (species thaliana) is built by using system identification techniques. Prior knowledge about the physical interactions of the genes and the proteins in the plant circadian system i...
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