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Zrinka Rajić
University of Zagreb
66Publications
8H-index
204Citations
Publications 69
Newest
Abstract Harmicines constitute novel hybrid compounds that combine two agents with reported antiplasmodial properties, namely β-carboline harmine and a cinnamic acid derivative (CAD). Cu(I) catalyzed azide-alkyne cycloaddition was employed for the preparation of three classes of hybrid molecules: N-harmicines 6a-i, O-harmicines 7a-i and N,O-bis-harmicines 8a-g,i. In vitro antiplasmodial activities of harmicines against the erythrocytic stage of Plasmodium falciparum (chloroquine-sensitive Pf3D7 ...
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#1Branka Zorc (University of Zagreb)H-Index: 18
#2Zrinka Rajić (University of Zagreb)H-Index: 8
Last.Ivana Perković (University of Zagreb)H-Index: 10
view all 3 authors...
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#1Branka Zorc (University of Zagreb)H-Index: 18
#2Ivana Perković (University of Zagreb)H-Index: 10
Last.Maja Beus (University of Zagreb)H-Index: 1
view all 5 authors...
Abstract Numerous modifications of the well-known antimalarial drug primaquine, both at the quinoline ring and at the primary amino group, have been reported, mostly to obtain antimalarial agents with improved bioavailability, reduced toxicity and/or prolonged activity. Modifications of the terminal amino group were made with the main idea to prevent the metabolic pathway leading to inactive and toxic carboxyprimaquine (follow-on strategy), but also to get compounds with different activity (repu...
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#1Kristina Pavić (University of Zagreb)H-Index: 6
#2Barbara Rubinić (University of Zagreb)
Last.Branka Zorc (University of Zagreb)H-Index: 18
view all 9 authors...
Abstract Primaquine homodimers, e.g. symmetric PQ-diamides of dicarboxylic acids containing 4 to 8 carbon atoms, were evaluated against Plasmodium berghei hepatic stages and P. falciparum blood stages, as well as against three cancer cell lines. Novel PQ-homodimers exerted much higher activity against hepatic stages, but less pronounced activity against blood stages in comparison to the parent drug. The submicromolar activity of succinic, fumaric and maleic derivatives against P. berghei was det...
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#2Bruno Lopes AbbadiH-Index: 4
Last.Zrinka RajićH-Index: 8
view all 5 authors...
#1Kristina Pavić (University of Zagreb)H-Index: 6
#2Zrinka Rajić (University of Zagreb)H-Index: 8
Last.Branka Zorc (University of Zagreb)H-Index: 18
view all 6 authors...
2 CitationsSource
#1Maja BeusH-Index: 2
#2Diana FontinhaH-Index: 3
Last.Branka ZorcH-Index: 18
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This paper describes a continuation of our efforts in the pursuit of novel antiplasmodial agents with optimized properties. Following our previous discovery of biologically potent asymmetric primaquine (PQ) and halogenaniline fumardiamides (1–6), we now report their significant in vitro activity against the hepatic stages of Plasmodium parasites. Furthermore, we successfully prepared chloroquine (CQ) analogue derivatives (11–16) and evaluated their activity against both the hepatic and erythrocy...
1 CitationsSource
#1Maja BeusH-Index: 2
#2Zrinka RajićH-Index: 8
#1Maja BeusH-Index: 2
#2Diana FontinhaH-Index: 3
Last.Branka ZorcH-Index: 18
view all 6 authors...
The paper is focused on the synthesis and screening of the antiplasmodial activity of novel fumardiamides 5–10 with the mefloquine pharmacophore and
1 CitationsSource
#1Ivana PerkovićH-Index: 10
#2Zrinka RajićH-Index: 8
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