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Karen E. Nelson
J. Craig Venter Institute
240Publications
71H-index
46.3kCitations
Publications 240
Newest
Published on Jan 7, 2019
Indresh Singh5
Estimated H-index: 5
,
Mehmet Kuscuoglu + 3 AuthorsKaren E. Nelson1
Estimated H-index: 1
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Published on May 16, 2019in bioRxiv
Yanbao Yu6
Estimated H-index: 6
(J. Craig Venter Institute),
Harinder Singh62
Estimated H-index: 62
(J. Craig Venter Institute)
+ 11 AuthorsManolito Torralba22
Estimated H-index: 22
(J. Craig Venter Institute)
Polymicrobial biofilms that form on indwelling urethral catheters used by neurogenic bladder patients are known to recur following catheter replacements. Uropathogens dominate in catheter biofilms (CBs), grow and disperse as multi-cellular aggregates. Their microbial complexity, the characteristics of host immune responses and the molecular crosstalk in this ecosystem are incompletely understood. By surveying eight patients over up to six months with meta-omics analysis methods, we shed new ligh...
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Published on May 8, 2019in bioRxiv
Larissa Pessoa2
Estimated H-index: 2
(University of Brasília),
Gajender Aleti (J. Craig Venter Institute)+ 8 AuthorsAdriana Campos Passanezi Sant’Ana4
Estimated H-index: 4
(University of São Paulo)
Systemic lupus erythematosus (SLE) is a potentially fatal complex autoimmune disease, that is characterized by widespread inflammation manifesting tissue damage and comorbidities across the human body including heart, blood vessels, joints, skin, liver, kidneys, and periodontal tissues. The etiology of SLE is partially attributed to a deregulated inflammatory response to microbial dysbiosis and environmental changes. In the mouth, the periodontal environment provides an optimal niche to assay lo...
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Published on May 2, 2019in Biotechnology & Biotechnological Equipment 1.23
Orville St.E. Roachford1
Estimated H-index: 1
(University of the West Indies),
Karen E. Nelson71
Estimated H-index: 71
(J. Craig Venter Institute),
Bidyut R. Mohapatra2
Estimated H-index: 2
(University of the West Indies)
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Published on Apr 25, 2019in American Journal of Physical Anthropology 2.90
Barbora Pafčo3
Estimated H-index: 3
,
Ashok K. Sharma + 9 AuthorsKaren E. Nelson71
Estimated H-index: 71
(J. Craig Venter Institute)
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Published on Apr 5, 2019in Journal of Proteome Research 3.95
Yi-Han Lin (J. Craig Venter Institute), Rodrigo Vargas Eguez1
Estimated H-index: 1
(J. Craig Venter Institute)
+ 7 AuthorsYanbao Yu6
Estimated H-index: 6
(J. Craig Venter Institute)
Clinical biomarkers identified by shotgun proteomics require proteins in body fluids or tissues to be enzymatically digested before being separated and sequenced by Liquid Chromatography-tandem Mass Spectrometry (LC-MS/MS). How well peptide signals can be resolved and detected is largely dependent on the quality of sample preparation. Conventional approaches such as in-gel, in-solution, and filter-based digestion, despite their extensive implementation by the community, become less appealing due...
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Published on Apr 1, 2019in Microbial Ecology 3.61
Yongwook Choi10
Estimated H-index: 10
(J. Craig Venter Institute),
Anirban Banerjee64
Estimated H-index: 64
(George Washington University)
+ 9 AuthorsKaren E. Nelson71
Estimated H-index: 71
(J. Craig Venter Institute)
Chronic wounds are wounds that have failed to heal after 3 months of appropriate wound care. Previous reports have identified a diverse collection of bacteria in chronic wounds, and it has been postulated that bacterial profile may contribute to delayed healing. The purpose of this study was to perform a microbiome assessment of the Wound Healing and Etiology (WE-HEAL) Study cohort, including underlying comorbidities less commonly studied in the context of chronic wounds, such as autoimmune dise...
1 Citations Source Cite
Published on Mar 1, 2019in Infection, Genetics and Evolution 2.54
Orville St.E. Roachford1
Estimated H-index: 1
(University of the West Indies),
Karen E. Nelson71
Estimated H-index: 71
(J. Craig Venter Institute),
Bidyut R. Mohapatra2
Estimated H-index: 2
(University of the West Indies)
Abstract Human Mycoplasma are opportunistic, facultative pathogens that are site-specific in their colonization of mucosal surfaces. They are responsible for significant annual morbidity in humans by causing acute illnesses and chronic auto-inflammatory diseases via modulation of the host's immune system. Accurate and reliable identification of Mycoplasma species and their strains are thus of upmost importance. This study, analysed for the first time, the effectiveness of a short (50 kb) genome ...
1 Citations Source Cite
Published on Mar 1, 2019in The ISME Journal 9.52
Katherine R. Amato18
Estimated H-index: 18
(Northwestern University),
Jon G. Sanders18
Estimated H-index: 18
(University of California, San Diego)
+ 26 AuthorsGregory Humphrey6
Estimated H-index: 6
(University of California, San Diego)
Over the past decade several studies have reported that the gut microbiomes of mammals with similar dietary niches exhibit similar compositional and functional traits. However, these studies rely heavily on samples from captive individuals and often confound host phylogeny, gut morphology, and diet. To more explicitly test the influence of host dietary niche on the mammalian gut microbiome we use 16S rRNA gene amplicon sequencing and shotgun metagenomics to compare the gut microbiota of 18 speci...
9 Citations Source Cite
Published on Feb 27, 2019in bioRxiv
Alessia Visconti6
Estimated H-index: 6
(King's College London),
Caroline Le Roy1
Estimated H-index: 1
(King's College London)
+ 10 AuthorsJ. Craig Venter89
Estimated H-index: 89
The human gut is inhabited by a complex and metabolically active microbial ecosystem regulating host health. While many studies have focused on the effect of individual microbial taxa, the metabolic potential of the entire gut microbial ecosystem has been largely under-explored. We characterised the gut microbiome of 1,004 twins via whole shotgun metagenomic sequencing (average 39M reads per sample). We observed greater similarity, across unrelated individuals, for functional metabolic pathways ...
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