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Susan E. Douglas
National Research Council
89Publications
32H-index
3,873Citations
Publications 89
Newest
2017
Rama K. Singh12
Estimated H-index: 12
,
Jeffrey W. Gallant18
Estimated H-index: 18
+ 2 AuthorsSusan E. Douglas32
Estimated H-index: 32
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M. Elise R. Graham2
Estimated H-index: 2
(Queen Elizabeth II Health Sciences Centre),
Robert Hart22
Estimated H-index: 22
(Queen Elizabeth II Health Sciences Centre)
+ 8 AuthorsS. Mark Taylor13
Estimated H-index: 13
(Queen Elizabeth II Health Sciences Centre)
Objectives Papillary thyroid cancer (PTC) is increasing in incidence. Fine needle aspiration is the gold standard for diagnosis, but results can be indeterminate. Identifying tissue and serum biomarkers, like microRNA, is therefore desirable. We sought to identify miRNA that is differentially expressed in the serum of patients with PTC.
18 Citations Source Cite
2015
Rama K. Singh12
Estimated H-index: 12
,
Drew C. Bethune1
Estimated H-index: 1
+ 1 AuthorsSusan E. Douglas32
Estimated H-index: 32
Lung cancer is the leading cause of cancer-related death worldwide, and the majority of cases (77%) are not diagnosed until the disease has spread to regional lymph nodes or distant sites. Even among Non-Small Cell Lung Cancer (NSCLC) adenocarcinoma patients who have been diagnosed early and where there has been no spread to lymph nodes, recurrence after surgical intervention is high. Improved understanding of the molecular alterations involved in aggressivity and recurrence of these tumors may ...
1 Citations Download PDF Cite
2015
Rama K. Singh12
Estimated H-index: 12
,
Susanne Penny6
Estimated H-index: 6
,
Susan E. Douglas32
Estimated H-index: 32
Personalized treatment of lung cancer using therapies that target activating oncogenic mutations such as EGFR and ALK has become the standard of care. Current molecular testing is routinely performed for single genes and increasingly in a multiplex format. However, the scarcity of sufficient biopsy material has necessitated a more high-throughput and comprehen - sive testing approach. Next Generation Sequencing (NGS) offers great promise as a highly sensitive method of detection for a variety of...
1 Citations Download PDF Cite
2014
Susan E. Douglas , Drew C. Bethune1
Estimated H-index: 1
+ 3 AuthorsXu Z. Mi
Recurrence after lung cancer surgery is high, even among Non-Small Cell Lung Can- cer (NSCLC) adenocarcinoma patients diagnosed early as Stage I, where there has been no spread to lymph nodes. Understanding the biological underpinnings of aggressivity and recur- rence in this subset of tumours may enable the identification of patients who would benefit from adjuvant therapy. The purpose of this study was to identify differentially expressed molecular biomarkers that might underlie recurrence of ...
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2013
Rama Singh1
Estimated H-index: 1
,
Susan E. Douglas32
Estimated H-index: 32
The present application provides a method and composition for identifying gene rearrangements, such as translocations, and determining the frequency of rearrangement, such as translocation, in a biological sample, for example, a tissue sample (fresh or preserved). The present methods can be carried out in multiplex for amplifying and/or identifying multiple translocations at one time.
Source
Fawaz M. Makki4
Estimated H-index: 4
(Queen Elizabeth II Health Sciences Centre),
S. Mark Taylor13
Estimated H-index: 13
(Queen Elizabeth II Health Sciences Centre)
+ 9 AuthorsKaren Inglis2
Estimated H-index: 2
(Queen Elizabeth II Health Sciences Centre)
Objective: To identify serum biomarkers of papillary thyroid cancer. Methods: Prospective analysis was performed of banked tumor and serum specimens from 99 patients with thyroid masses. Enzyme-linked immunosorbent assay (ELISA) was employed to measure levels of five serum proteins previously demonstrated to be up-regulated in papillary thyroid cancer (PTC): angiopoietin-1 (Ang-1), cytokeratin 19 (CK-19), tissue inhibitor of metalloproteinase-1 (TIMP-1), chitinase 3 like-1 (YKL-40), and galectin...
13 Citations Source Cite
2012 in Chemical ScienceIF: 9.06
Stephanie N. Dupuis4
Estimated H-index: 4
(Dalhousie University),
Andrew W. Robertson6
Estimated H-index: 6
(Dalhousie University)
+ 6 AuthorsDavid L. Jakeman21
Estimated H-index: 21
(Dalhousie University)
Growth of Streptomyces venezuelae ISP5230 with O-propargyl-L-serine led to the efficient production of an alkyne-containing jadomycin. The installed alkyne functionality provided a uniquely reactive handle within the natural product and was subsequently reacted with a series of azides to afford an eight-member library of jadomycin triazoles. The compounds were evaluated for their DNA cleavage, antibacterial and cytotoxic properties.
23 Citations Source Cite
Michael G. Morash7
Estimated H-index: 7
,
Susan E. Douglas32
Estimated H-index: 32
+ 3 AuthorsKelly H. Soanes7
Estimated H-index: 7
The emergence of multidrug-resistant cancers and the lack of targeted therapies for many cancers underscore an unmet need for new therapeutics with novel modes of action towards cancer cells. Host-defense peptides often exhibit selective cytotoxicity towards cancer cells and show potential as anti-cancer therapeutics. Here, we screen 26 naturally occurring variants of the peptide pleurocidin for cytotoxic and anti-cancer activities, and investigate the underlying mechanism of action. Cytotoxicit...
15 Citations Download PDF Cite
Stephanie N. Dupuis4
Estimated H-index: 4
,
Thomas Veinot3
Estimated H-index: 3
+ 5 AuthorsDavid L. Jakeman21
Estimated H-index: 21
Streptomyces venezuelae ISP5230 is recognized for the production of chloramphenicol and the jadomycin family of natural products. The jadomycins are angucycline natural products containing a unique oxazolone ring incorporating an amino acid present in the minimal culture media. Substitution of different amino acids results in products of varying biological activity. Analysis of cultures of S. venezuelae ISP5230 incubated with l- and d-norvaline and l- and d-norleucine indicated that only the d-c...
16 Citations Download PDF Cite
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