Susan E. Douglas
National Research Council
89Publications
37H-index
3,887Citations
Publications 89
Newest
M. Elise R. Graham2
Estimated H-index: 2
(Queen Elizabeth II Health Sciences Centre),
Robert A. Hart39
Estimated H-index: 39
(Queen Elizabeth II Health Sciences Centre)
+ 8 AuthorsS. Mark Taylor13
Estimated H-index: 13
(Queen Elizabeth II Health Sciences Centre)
Objectives Papillary thyroid cancer (PTC) is increasing in incidence. Fine needle aspiration is the gold standard for diagnosis, but results can be indeterminate. Identifying tissue and serum biomarkers, like microRNA, is therefore desirable. We sought to identify miRNA that is differentially expressed in the serum of patients with PTC.
20 Citations Source Cite
Fawaz M. Makki7
Estimated H-index: 7
(Queen Elizabeth II Health Sciences Centre),
S. Mark Taylor13
Estimated H-index: 13
(Queen Elizabeth II Health Sciences Centre)
+ 9 AuthorsKaren Inglis2
Estimated H-index: 2
(Queen Elizabeth II Health Sciences Centre)
Objective: To identify serum biomarkers of papillary thyroid cancer. Methods: Prospective analysis was performed of banked tumor and serum specimens from 99 patients with thyroid masses. Enzyme-linked immunosorbent assay (ELISA) was employed to measure levels of five serum proteins previously demonstrated to be up-regulated in papillary thyroid cancer (PTC): angiopoietin-1 (Ang-1), cytokeratin 19 (CK-19), tissue inhibitor of metalloproteinase-1 (TIMP-1), chitinase 3 like-1 (YKL-40), and galectin...
13 Citations Source Cite
Published on Jan 1, 2012in Chemical Science 9.06
Stephanie N. Dupuis4
Estimated H-index: 4
(Dalhousie University),
Andrew W. Robertson7
Estimated H-index: 7
(Dalhousie University)
+ 6 AuthorsDavid L. Jakeman16
Estimated H-index: 16
(Dalhousie University)
Growth of Streptomyces venezuelae ISP5230 with O-propargyl-L-serine led to the efficient production of an alkyne-containing jadomycin. The installed alkyne functionality provided a uniquely reactive handle within the natural product and was subsequently reacted with a series of azides to afford an eight-member library of jadomycin triazoles. The compounds were evaluated for their DNA cleavage, antibacterial and cytotoxic properties.
23 Citations Source Cite
Published on Sep 1, 2011in Disease Models & Mechanisms 4.40
Michael G. Morash7
Estimated H-index: 7
,
Susan E. Douglas37
Estimated H-index: 37
+ 3 AuthorsKelly H. Soanes7
Estimated H-index: 7
The emergence of multidrug-resistant cancers and the lack of targeted therapies for many cancers underscore an unmet need for new therapeutics with novel modes of action towards cancer cells. Host-defense peptides often exhibit selective cytotoxicity towards cancer cells and show potential as anti-cancer therapeutics. Here, we screen 26 naturally occurring variants of the peptide pleurocidin for cytotoxic and anti-cancer activities, and investigate the underlying mechanism of action. Cytotoxicit...
15 Citations Source Cite
Published on Nov 28, 2011in Journal of Natural Products 3.88
Stephanie N. Dupuis4
Estimated H-index: 4
,
Thomas Veinot3
Estimated H-index: 3
+ 5 AuthorsDavid L. Jakeman16
Estimated H-index: 16
Streptomyces venezuelae ISP5230 is recognized for the production of chloramphenicol and the jadomycin family of natural products. The jadomycins are angucycline natural products containing a unique oxazolone ring incorporating an amino acid present in the minimal culture media. Substitution of different amino acids results in products of varying biological activity. Analysis of cultures of S. venezuelae ISP5230 incubated with l- and d-norvaline and l- and d-norleucine indicated that only the d-c...
16 Citations Source Cite
Published on Nov 1, 2010in Chemometrics and Intelligent Laboratory Systems 2.70
Tobias K. Karakach13
Estimated H-index: 13
(National Research Council),
Robert M. Flight12
Estimated H-index: 12
(Dalhousie University)
+ 1 AuthorsPeter D. Wentzell25
Estimated H-index: 25
(Dalhousie University)
This tutorial presents a basic introduction to DNA microarrays as employed for gene expression analysis, approaching the subject from a chemometrics perspective. The emphasis is on describing the nature of the measurement process, from the platforms used to a few of the standard higher-level data analysis tools employed. Topics include experimental design, detection, image processing, measurement errors, ratio calculation, background correction, normalization, and higher-level data processing. T...
34 Citations Source Cite
Published on Apr 1, 2010in Marine Biotechnology 2.33
Harry M. Murray16
Estimated H-index: 16
,
Santosh P. Lall33
Estimated H-index: 33
+ 7 AuthorsSusan E. Douglas37
Estimated H-index: 37
An experimental microdiet prepared using an internal gelation method was used to partially replace the traditional live feed (Artemia) for larval Atlantic halibut, Hippoglossus hippoglossus L. Three trials were conducted with microdiet introduced at 20, 32, and 43 days post first feeding and larvae were sampled at approximately 2, 13, 23, and 33 days after microdiet introduction in each trial. The success of feeding was assessed by morphometrics and histological analysis of gut contents. Microdi...
22 Citations Source Cite
Published on Jan 1, 2010in Aquaculture 2.71
Harry M. Murray16
Estimated H-index: 16
(National Research Council),
Santosh P. Lall33
Estimated H-index: 33
(National Research Council)
+ 6 AuthorsSusan E. Douglas37
Estimated H-index: 37
(National Research Council)
Abstract Aquaculture feeds for carnivorous finfish species have been dependent upon the use of fish meal as the major source of dietary protein; however, the increasing demands upon the finite quantity of this high-quality protein source requires that feeds become increasingly comprised of alternative plant and/or animal protein. Soybean meal has been has been used to partially replace fish meal in the diets of several fish but it is known to cause enteritis in Atlantic salmon, Salmo salar . We ...
43 Citations Source Cite
Published on Oct 1, 2010in Journal of Fish Biology 1.70
Joan Cerdà28
Estimated H-index: 28
(Spanish National Research Council),
Susan E. Douglas37
Estimated H-index: 37
(Halifax),
Michael Reith26
Estimated H-index: 26
(Halifax)
Flatfishes are a group of teleosts of high commercial and environmental interest, whose biology is still poorly understood. The recent rapid development of different ‘omic’ technologies is, however, enhancing the knowledge of the complex genetic control underlying different physiological processes of flatfishes. This review describes the different functional genomic approaches and resources currently available for flatfish research and summarizes different areas where microarray-based gene expre...
31 Citations Source Cite
Published on May 1, 2009in Cancer Research 9.13
Ashley L. Hilchie7
Estimated H-index: 7
,
Aleksander Patrzykat3
Estimated H-index: 3
+ 1 AuthorsDavid W. Hoskin33
Estimated H-index: 33
Cationic antimicrobial peptides are small peptides that constitute an important defense against microbial pathogens and, in some cases, also exhibit potent cytotoxic activity against cancer cells. Atlantic pleuronectid flatfish are a particularly rich source of cationic antimicrobial peptides, including NRC-03 and NRC-07, which are pleurocidin-like peptides derived from winter and yellowtail flounder, respectively. The purpose of this investigation was to evaluate the potential of NRC-03 and NRC...
123456789