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Dan Liu
Baylor College of Medicine
61Publications
26H-index
3,273Citations
Publications 61
Newest
Published on Jan 8, 2019in Nature Communications 12.35
Puping Liang7
Estimated H-index: 7
(SYSU: Sun Yat-sen University),
Xiaowei Xie6
Estimated H-index: 6
(SYSU: Sun Yat-sen University)
+ 9 AuthorsDan Liu26
Estimated H-index: 26
(BCM: Baylor College of Medicine)
The adenine base editor (ABE), capable of catalyzing A•T to G•C conversions, is an important gene editing toolbox. Here, we systematically evaluate genome-wide off-target deamination by ABEs using the EndoV-seq platform we developed. EndoV-seq utilizes Endonuclease V to nick the inosine-containing DNA strand of genomic DNA deaminated by ABE in vitro. The treated DNA is then whole-genome sequenced to identify off-target sites. Of the eight gRNAs we tested with ABE, 2–19 (with an average of 8.0) o...
7 Citations Source Cite
Published on May 1, 2019in Protein & Cell 6.23
Jianxi Zhu (SYSU: Sun Yat-sen University), Mingyang Xu (SYSU: Sun Yat-sen University)+ 6 AuthorsZhou Songyang43
Estimated H-index: 43
(SYSU: Sun Yat-sen University)
Source Cite
Published on Jan 10, 2019in Nucleic Acids Research 11.56
Tingting Deng3
Estimated H-index: 3
(SYSU: Sun Yat-sen University),
Yan Huang26
Estimated H-index: 26
(SYSU: Sun Yat-sen University)
+ 8 AuthorsWenbin Ma12
Estimated H-index: 12
(SYSU: Sun Yat-sen University)
3 Citations Source Cite
Published on Sep 1, 2018in Protein & Cell 6.23
Puping Liang7
Estimated H-index: 7
(SYSU: Sun Yat-sen University),
Hongwei Sun4
Estimated H-index: 4
(SYSU: Sun Yat-sen University)
+ 10 AuthorsWenbin Ma12
Estimated H-index: 12
(SYSU: Sun Yat-sen University)
2 Citations Source Cite
Published on May 1, 2018in Molecular Cell 14.25
Feng Li5
Estimated H-index: 5
(SYSU: Sun Yat-sen University),
Hyeung Kim11
Estimated H-index: 11
(BCM: Baylor College of Medicine)
+ 12 AuthorsHuimin Xu1
Estimated H-index: 1
(SYSU: Sun Yat-sen University)
Summary Telomeres and telomere-binding proteins form complex secondary nucleoprotein structures that are critical for genome integrity but can present serious challenges during telomere DNA replication. It remains unclear how telomere replication stress is resolved during S phase. Here, we show that the BUB3-BUB1 complex, a component in spindle assembly checkpoint, binds to telomeres during S phase and promotes telomere DNA replication. Loss of the BUB3-BUB1 complex results in telomere replicati...
5 Citations Source Cite
Published on Feb 1, 2018in Cell Reports 8.03
Yi Liu1
Estimated H-index: 1
(SYSU: Sun Yat-sen University),
Feng Liu8
Estimated H-index: 8
(SYSU: Sun Yat-sen University)
+ 7 AuthorsWenbin Ma12
Estimated H-index: 12
(SYSU: Sun Yat-sen University)
Summary Shwachman-Diamond syndrome (SDS) is a rare pediatric disease characterized by various systemic disorders, including hematopoietic dysfunction. The mutation of Shwachman-Bodian-Diamond syndrome ( SBDS ) gene has been proposed to be a major causative reason for SDS. Although SBDS patients were reported to have shorter telomere length in granulocytes, the underlying mechanism is still unclear. Here we provide data to elucidate the role of SBDS in telomere protection. We demonstrate that SBD...
1 Citations Source Cite
Published on Dec 1, 2017in Cell discovery
Hyeung Kim11
Estimated H-index: 11
,
Feng Li5
Estimated H-index: 5
+ 7 AuthorsZhou Songyang43
Estimated H-index: 43
Systematic analysis of human telomeric dysfunction using inducible telosome/shelterin CRISPR/Cas9 knockout cells
5 Citations Source Cite
Published on Dec 1, 2017in Cell discovery
Yuxi Chen6
Estimated H-index: 6
,
Puping Liang7
Estimated H-index: 7
+ 13 AuthorsYuanzhu Gao1
Estimated H-index: 1
Glycerol kinase-like proteins cooperate with Pld6 in regulating sperm mitochondrial sheath formation and male fertility
2 Citations Source Cite
Published on Nov 1, 2017in Protein & Cell 6.23
Puping Liang7
Estimated H-index: 7
(SYSU: Sun Yat-sen University),
Chenhui Ding14
Estimated H-index: 14
(SYSU: Sun Yat-sen University)
+ 13 AuthorsYongxiang Liu1
Estimated H-index: 1
(SYSU: Sun Yat-sen University)
β-Thalassemia is a global health issue, caused by mutations in the HBB gene. Among these mutations, HBB −28 (A>G) mutations is one of the three most common mutations in China and Southeast Asia patients with β-thalassemia. Correcting this mutation in human embryos may prevent the disease being passed onto future generations and cure anemia. Here we report the first study using base editor (BE) system to correct disease mutant in human embryos. Firstly, we produced a 293T cell line with an exogen...
38 Citations Source Cite
Published on Aug 1, 2017in Protein & Cell 6.23
Puping Liang7
Estimated H-index: 7
(SYSU: Sun Yat-sen University),
Hongwei Sun4
Estimated H-index: 4
(SYSU: Sun Yat-sen University)
+ 11 AuthorsYuanyan Xiong6
Estimated H-index: 6
(SYSU: Sun Yat-sen University)
Targeted point mutagenesis through homologous recombination has been widely used in genetic studies and holds considerable promise for repairing disease-causing mutations in patients. However, problems such as mosaicism and low mutagenesis efficiency continue to pose challenges to clinical application of such approaches. Recently, a base editor (BE) system built on cytidine (C) deaminase and CRISPR/Cas9 technology was developed as an alternative method for targeted point mutagenesis in plant, ye...
23 Citations Source Cite
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