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Isidre Ferrer
Bellvitge University Hospital
544Publications
72H-index
19.2kCitations
Publications 544
Newest
Published on Dec 1, 2019in Journal of Neuroinflammation 5.70
Anna Villar-Piqué11
Estimated H-index: 11
,
Matthias Schmitz17
Estimated H-index: 17
(German Center for Neurodegenerative Diseases)
+ 7 AuthorsInga Zerr57
Estimated H-index: 57
(German Center for Neurodegenerative Diseases)
Background Increased plasma YKL-40 has been reported in Alzheimer’s disease (AD), but its levels in other neurodegenerative diseases are unknown. Here, we aimed to investigate plasma YKL-40 in the spectrum of neurodegenerative dementias.
Published on Mar 27, 2019in Nature Communications 11.88
Montse Olivé26
Estimated H-index: 26
,
Martin Engvall6
Estimated H-index: 6
(Karolinska University Hospital)
+ 41 AuthorsAlistair R. R. Forrest44
Estimated H-index: 44
(Harry Perkins Institute of Medical Research)
Myoglobin, encoded by MB, is a small cytoplasmic globular hemoprotein highly expressed in cardiac myocytes and oxidative skeletal myofibers. Myoglobin binds O2, facilitates its intracellular transport and serves as a controller of nitric oxide and reactive oxygen species. Here, we identify a recurrent c.292C>T (p.His98Tyr) substitution in MB in fourteen members of six European families suffering from an autosomal dominant progressive myopathy with highly characteristic sarcoplasmic inclusions in...
Published on Aug 1, 2018in Biochimica et Biophysica Acta 3.79
Félix Hernández41
Estimated H-index: 41
(CSIC: Spanish National Research Council),
Raquel Cuadros10
Estimated H-index: 10
(CSIC: Spanish National Research Council)
+ 4 AuthorsJesús Avila71
Estimated H-index: 71
(CSIC: Spanish National Research Council)
Abstract The main difference between the primary structures of human and mouse tau can be found at the N-terminal end of the protein. Residues 17 to 28 in human tau are not present in the mouse form of the molecule. Here we tested the capacity of these human tau residues to bind to specific proteins. Several proteins were observed to bind to these residues. Among those that showed the greatest binding were three related to energetic processes: enolase, glyceraldehyde 3 phosphate dehydrogenase an...
Published on Jan 4, 2019in Molecular Neurobiology 4.59
Ester Aso20
Estimated H-index: 20
(University of Barcelona),
Víctor Fernández-Dueñas16
Estimated H-index: 16
(University of Barcelona)
+ 5 AuthorsFrancisco Ciruela54
Estimated H-index: 54
(University of Barcelona)
At present, clinical interest in the plant-derived cannabinoid compound cannabidiol (CBD) is rising exponentially, since it displays multiple therapeutic properties. In addition, CBD can counteract the undesirable effects of the psychoactive cannabinoid Δ9-tetrahydrocannabinol (Δ9-THC) that hinder clinical development of cannabis-based therapies. Despite this attention, the mechanisms of CBD action and its interaction with Δ9-THC are still not completely elucidated. Here, by combining in vivo an...
Published on Jul 23, 2019in International Journal of Molecular Sciences 4.18
Víctor Fernández-Dueñas16
Estimated H-index: 16
,
Maricel Gómez-Soler8
Estimated H-index: 8
+ 3 AuthorsFrancisco Ciruela54
Estimated H-index: 54
Background: Several biophysical techniques have been successfully implemented to detect G protein-coupled receptors (GPCRs) heteromerization. Although these approaches have made it possible to ascertain the presence of GPCR heteromers in animal models of disease, no success has been accomplished in pathological human post-mortem brains. The AlphaScreen technology has been consistently used to quantify small analyte accumulation or depletion, bimolecular interactions, and post-translational modif...
Published on Jun 19, 2019in Neuropathology and Applied Neurobiology 6.88
Franc Llorens20
Estimated H-index: 20
(ISCIII: Instituto de Salud Carlos III),
Anna Villar-Piqué11
Estimated H-index: 11
+ 12 AuthorsJean-Jacques Hauw67
Estimated H-index: 67
Published on Jul 3, 2019in Journal of the History of the Neurosciences 0.24
Santiago Giménez-Roldán (Hospital General Universitario Gregorio Marañón), F. Morales-Asín + 1 AuthorsPeter S. Spencer57
Estimated H-index: 57
(OHSU: Oregon Health & Science University)
Published on Jun 26, 2019in bioRxiv
Omar Ramírez-Núñez6
Estimated H-index: 6
,
Mariona Jové24
Estimated H-index: 24
+ 11 AuthorsMónica Povedano9
Estimated H-index: 9
In this pilot study, we show that nuclei in spinal cord from ALS patients exhibit a differential lipidomic signature. Among the differential lipid species we could annotate 41 potential identities. These comprise membrane-bound lipids such as phosphatidylethanolamines -including plasmalogens- and phosphatidylcholines but also other lipid classes such as glycosphingolipids, diacylglycerols, and triacylglycerides (potentially present as nuclear lipid droplets). These results were orthogonally vali...
Published on Jun 12, 2019in Journal of Neurology 4.20
María Elena Erro1
Estimated H-index: 1
(Universidad Pública de Navarra),
María Victoria Zelaya5
Estimated H-index: 5
+ 10 AuthorsF. García-Bragado1
Estimated H-index: 1
Objective To describe the clinical, biochemical, and neuropathological findings of an autosomal dominant globular glial tauopathy caused by the P301T mutation at the MAPT gene.
Published on May 17, 2019in Human Mutation 4.45
Frederic Tort9
Estimated H-index: 9
,
Olatz Ugarteburu2
Estimated H-index: 2
+ 18 AuthorsIsidre Ferrer72
Estimated H-index: 72
(Bellvitge University Hospital)
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