Isidre Ferrer
University of Barcelona
Publications 559
#1José GazullaH-Index: 10
#2Isidre Ferrer (Bellvitge University Hospital)H-Index: 74
Last.José Berciano (UC: University of Cantabria)H-Index: 48
view all 3 authors...
#1Anna Villar-PiquéH-Index: 13
#2Matthias Schmitz (German Center for Neurodegenerative Diseases)H-Index: 18
Last.Inga Zerr (German Center for Neurodegenerative Diseases)H-Index: 59
view all 10 authors...
Background Increased plasma YKL-40 has been reported in Alzheimer’s disease (AD), but its levels in other neurodegenerative diseases are unknown. Here, we aimed to investigate plasma YKL-40 in the spectrum of neurodegenerative dementias.
#1Montse OlivéH-Index: 26
#2Martin Engvall (Karolinska University Hospital)H-Index: 6
Last.Nigel G. Laing (Harry Perkins Institute of Medical Research)H-Index: 61
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Myoglobin, encoded by MB, is a small cytoplasmic globular hemoprotein highly expressed in cardiac myocytes and oxidative skeletal myofibers. Myoglobin binds O2, facilitates its intracellular transport and serves as a controller of nitric oxide and reactive oxygen species. Here, we identify a recurrent c.292C>T (p.His98Tyr) substitution in MB in fourteen members of six European families suffering from an autosomal dominant progressive myopathy with highly characteristic sarcoplasmic inclusions in...
#1Pascual TorresH-Index: 3
#2Daniel CacabelosH-Index: 11
Last.Victoria AyalaH-Index: 23
view all 13 authors...
Docosahexaenoic acid (DHA) is an essential fatty acid modulating key nervous system functions, including neuroinflammation, and regulation of pre- and postsynaptic membrane formation. DHA concentration decreases in the lumbar spinal cord (LSC) of amyotrophic lateral sclerosis (ALS) patients and murine preclinical models. Using a dietary supplementation, we increased DHA levels (2% mean increase, p < 0.01) in the LSC of the familial ALS murine model B6SJL-Tg(SOD1*G93A)1Gur/J. This DHA-enriched di...
#1Santiago Giménez-Roldán (Hospital General Universitario Gregorio Marañón)H-Index: 1
#2F. Morales-AsínH-Index: 1
Last.Peter S. Spencer (OHSU: Oregon Health & Science University)H-Index: 58
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ABSTRACTLathyrism is a central motor system disorder recognized since antiquity resulting from prolonged dietary dependence on the grasspea (Lathyrus sativus). The neuropathology underlying the cha...
1 CitationsSource
#1M. E. Erro (Universidad Pública de Navarra)H-Index: 2
Last.Isidre Ferrer (Bellvitge University Hospital)H-Index: 74
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Objective To describe the clinical, biochemical, and neuropathological findings of an autosomal dominant globular glial tauopathy caused by the P301T mutation at the MAPT gene.
1 CitationsSource
#1Frederic TortH-Index: 10
#2Olatz UgarteburuH-Index: 3
Last.Antonia RibesH-Index: 32
view all 21 authors...
3-Methylglutaconic aciduria (3-MGA-uria) syndromes comprise a heterogeneous group of diseases associated with mitochondrial membrane defects. Whole-exome sequencing identified compound heterozygous mutations in TIMM50 (c.[341 G>A];[805 G>A]) in a boy with West syndrome, optic atrophy, neutropenia, cardiomyopathy, Leigh syndrome, and persistent 3-MGA-uria. A comprehensive analysis of the mitochondrial function was performed in fibroblasts of the patient to elucidate the molecular basis of the dis...
#1Eirini Kanata (A.U.Th.: Aristotle University of Thessaloniki)H-Index: 6
#2Franc Llorens (ISCIII: Carlos III Health Institute)H-Index: 23
Last.Theodoros Sklaviadis (A.U.Th.: Aristotle University of Thessaloniki)H-Index: 24
view all 18 authors...
Prion diseases are fatal neurodegenerative disorders caused by misfolding of the normal prion protein into an infectious cellular pathogen. Clinically characterized by rapidly progressive dementia and accounting for 85% of human prion disease cases, sporadic Creutzfeldt–Jakob disease (sCJD) is the prevalent human prion disease. Although sCJD neuropathological hallmarks are well-known, associated molecular alterations are elusive due to rapid progression and absence of preclinical stages. To inve...
2 CitationsSource
#1Félix Hernández (CSIC: Spanish National Research Council)H-Index: 41
#2Raquel Cuadros (CSIC: Spanish National Research Council)H-Index: 11
Last.Jesús Avila (CSIC: Spanish National Research Council)H-Index: 79
view all 7 authors...
Abstract The main difference between the primary structures of human and mouse tau can be found at the N-terminal end of the protein. Residues 17 to 28 in human tau are not present in the mouse form of the molecule. Here we tested the capacity of these human tau residues to bind to specific proteins. Several proteins were observed to bind to these residues. Among those that showed the greatest binding were three related to energetic processes: enolase, glyceraldehyde 3 phosphate dehydrogenase an...
2 CitationsSource