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Michael E. Thase
University of Pennsylvania
951Publications
112H-index
54.1kCitations
Publications 951
Newest
#1Masoud Kamali (UM: University of Michigan)H-Index: 17
#2Noreen A. Reilly-Harrington (Harvard University)H-Index: 20
Last.James H. Kocsis (Cornell University)H-Index: 54
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Abstract Introduction Not all patients with bipolar depression have suicidal ideation (SI). This study examines some factors that link bipolar depression to SI. Methods 482 individuals with bipolar I or II were randomized to either lithium or quetiapine plus adjunctive personalized therapy in a 24 week comparative effectiveness trial. Severity of depression and SI were assessed with the Bipolar Inventory of Symptoms Scale (BISS). We examined potential moderators (age, gender, age of illness onse...
#1Michael E. Thase (UPenn: University of Pennsylvania)H-Index: 112
#2Peter Zhang (Princeton University)H-Index: 5
Last.Mary Hobart (Princeton University)H-Index: 4
view all 5 authors...
#1Vicki Fung (Harvard University)H-Index: 16
#2Lindsay Overhage (Harvard University)
Last.Michael E. Thase (UPenn: University of Pennsylvania)H-Index: 112
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Abstract Background Complex polypharmacy (CP) is common in bipolar disorder (BD). We assessed the associations between CP, adherence, and side effect burden, and patient traits associated with clinical improvement in relationship to CP. Methods We conducted a secondary analysis of 482 adult BD participants in the Bipolar CHOICE trial. We examined the associations between CP (use of ≥3 BD medications) and non-adherence (missing >30% of BD medication doses in the last 30 days) and side effect burd...
#1Ella J. Daly (Janssen Pharmaceutica)H-Index: 14
#2Madhukar H. Trivedi (UTSW: University of Texas Southwestern Medical Center)H-Index: 89
Last.David Hough (Janssen Pharmaceutica)H-Index: 22
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Importance Controlled studies have shown short-term efficacy of esketamine for treatment-resistant depression (TRD), but long-term effects remain to be established. Objective To assess the efficacy of esketamine nasal spray plus an oral antidepressant compared with an oral antidepressant plus placebo nasal spray in delaying relapse of depressive symptoms in patients with TRD in stable remission after an induction and optimization course of esketamine nasal spray plus an oral antidepressant. Desi...
#1Donald M. BushnellH-Index: 25
#2K.P. McCarrierH-Index: 4
Last.Michael E. ThaseH-Index: 112
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Abstract Background The Symptoms of Major Depressive Disorder Scale (SMDDS) was expressly developed on the basis of qualitative data to directly incorporate patients' voices into evaluation of treatment benefit in major depressive disorder (MDD) clinical trials. Objectives To collect quantitative data necessary to refine/optimize the SMDDS and document its psychometric properties. Methods In this multicenter, observational study, participants with clinically diagnosed MDD completed questionnaire...
#2Louisa G. SylviaH-Index: 22
Last.Terence A. KetterH-Index: 67
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Immune system markers may predict affective disorder treatment response, but whether an overall immune system marker predicts bipolar disorder treatment effect is unclear. Bipolar CHOICE (N = 482) and LiTMUS (N = 283) were similar comparative effectiveness trials treating patients with bipolar disorder for 24 weeks with four different treatment arms (standard-dose lithium, quetiapine, moderate-dose lithium plus optimised personalised treatment (OPT) and OPT without lithium). We performed seconda...
#1Joseph M. Trombello (UTSW: University of Texas Southwestern Medical Center)H-Index: 5
#2Jeffrey R. Vittengl (TSU: Truman State University)H-Index: 21
Last.Robin B. Jarrett (UTSW: University of Texas Southwestern Medical Center)H-Index: 33
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Abstract Major depressive disorder (MDD) and relationship discord between cohabiting partners frequently co-occur, with bidirectional effects established. As relationship quality influences understanding and treatment of MDD, the current analyses clarified the relations of pretreatment dyadic discord with outcomes during and at the end of acute phase cognitive therapy (CT) for adults with recurrent MDD. Married or cohabiting patients ( n = 219) completed the Dyadic Adjustment Scale (DYS) before ...
#1Jeffrey R. Vittengl (TSU: Truman State University)H-Index: 21
#2Lee Anna Clark (ND: University of Notre Dame)H-Index: 68
Last.Robin B. JarrettH-Index: 33
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Abstract Patients’ beliefs about depression and expectations for treatment can influence outcomes of major depressive disorder (MDD) treatments. We hypothesized that patients with weaker biological beliefs (less endorsement of [a] biochemical causes and [b] need for medication) and more optimistic treatment expectations (greater improvement and shorter time to improvement), have better outcomes in cognitive therapy (CT). Outpatients with recurrent MDD who received acute-phase CT ( N = 152), and ...
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