Sarah E. Harris
University of Edinburgh
Publications 754
#1Catherine M. Calvin (University of Oxford)H-Index: 12
#2Saskia P. Hagenaars (Edin.: University of Edinburgh)H-Index: 21
Last.Ian J. Deary (Edin.: University of Edinburgh)H-Index: 128
view all 8 authors...
Evidence suggests that lifestyle factors, e.g. physical activity, moderate the manifestation of genetic susceptibility to obesity. The present study uses UK Biobank data to investigate interaction between polygenic scores (PGS) for two obesity indicators, and lifestyle and psychosocial factors in the prediction of the two indicators, with attention to sex-specific effects. Analyses were of 112 151 participants (58 914 females; 40 to 73 years) whose genetic data passed quality control. Moderation...
1 CitationsSource
#1Philip J. Law (ICR: Institute of Cancer Research)H-Index: 12
#2Maria Timofeeva (Medical Research Council)H-Index: 10
Last.Malcolm G. Dunlop (Medical Research Council)H-Index: 66
view all 98 authors...
Colorectal cancer (CRC) is a leading cause of cancer-related death worldwide, and has a strong heritable basis. We report a genome-wide association analysis of 34,627 CRC cases and 71,379 controls of European ancestry that identifies SNPs at 31 new CRC risk loci. We also identify eight independent risk SNPs at the new and previously reported European CRC loci, and a further nine CRC SNPs at loci previously only identified in Asian populations. We use in situ promoter capture Hi-C (CHi-C), gene e...
4 CitationsSource
#1Gail Davies (Edin.: University of Edinburgh)H-Index: 52
#2Max LamH-Index: 10
Last.Ian J. Deary (Edin.: University of Edinburgh)H-Index: 128
view all 222 authors...
Christina M. Lill, who contributed to analysis of data, was inadvertently omitted from the author list in the originally published version of this article. This has now been corrected in both the PDF and HTML versions of the article.
1 CitationsSource
#1Tuomas O. Kilpelaeinen (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 33
#2Amy R. Bentley (NIH: National Institutes of Health)H-Index: 16
Last.Ruth Loos (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 111
view all 237 authors...
Many genetic loci affect circulating lipid levels, but it remains unknown whether lifestyle factors, such as physical activity, modify these genetic effects. To identify lipid loci interacting with physical activity, we performed genome-wide analyses of circulating HDL cholesterol, LDL cholesterol, and triglyceride levels in up to 120,979 individuals of European, African, Asian, Hispanic, and Brazilian ancestry, with follow-up of suggestive associations in an additional 131,012 individuals. We f...
6 CitationsSource
#1Delphine B. Maurel (University of Bordeaux)H-Index: 1
#2Tsutomu Matsumoto (IU: Indiana University)H-Index: 1
Last.Lynda F. Bonewald (IU: Indiana University)H-Index: 80
view all 11 authors...
Transgenic mice are widely used to delete or overexpress genes in a cell specific manner to advance knowledge of bone biology, function and disease. While numerous Cre models exist to target gene recombination in osteoblasts and osteoclasts, few target osteocytes specifically, particularly mature osteocytes. Our goal was to create a spatial and temporal conditional Cre model using tamoxifen to induce Cre activity in mature osteocytes using a Bac construct containing the 5’ and 3’ regions of the ...
1 CitationsSource
#1Robert F. Hillary (Edin.: University of Edinburgh)H-Index: 3
#2Daniel L. McCartney (Edin.: University of Edinburgh)H-Index: 5
Last.Riccardo E. Marioni (Edin.: University of Edinburgh)H-Index: 40
view all 15 authors...
Although plasma proteins may serve as markers of neurological disease risk, the molecular mechanisms responsible for inter-individual variation in plasma protein levels are poorly understood. Therefore, we conduct genome- and epigenome-wide association studies on the levels of 92 neurological proteins to identify genetic and epigenetic loci associated with their plasma concentrations (n = 750 healthy older adults). We identify 41 independent genome-wide significant (P < 5.4 × 10−10) loci for 33 ...
#1Mihail Halachev (Edin.: University of Edinburgh)H-Index: 4
#2Alison Meynert (Edin.: University of Edinburgh)H-Index: 7
Last.James F. Wilson (Edin.: University of Edinburgh)H-Index: 3
view all 16 authors...
Human population isolates provide a snapshot of the impact of historical demographic processes on population genetics. Such data facilitate studies of the functional impact of rare sequence variants on biomedical phenotypes, as strong genetic drift can result in higher frequencies of variants that are otherwise rare. We present the first whole genome sequencing (WGS) study of the VIKING cohort, a representative collection of samples from the isolated Shetland population in northern Scotland, and...
#1Jo DorningH-Index: 1
#2Sarah E. HarrisH-Index: 98
Last.Stephen HarrisH-Index: 13
view all 2 authors...
2 CitationsSource
#1Yun J. Sung (WashU: Washington University in St. Louis)H-Index: 7
#2L de Las Fuentes (WashU: Washington University in St. Louis)H-Index: 2
Last.Alanna C. Morrison (University of Texas Health Science Center at Houston)H-Index: 44
view all 279 authors...
U.S. National Heart, Lung, and Blood Institute (NHLBI) (K25HL121091 to Y.J.S.); National Institutes of Health (R01HL118305).
#1Robert F. Hillary (Edin.: University of Edinburgh)H-Index: 3
#2Daniel L. McCartney (Edin.: University of Edinburgh)H-Index: 5
Last.Riccardo E. Marioni (Edin.: University of Edinburgh)H-Index: 40
view all 15 authors...
Data supporting the paper Hillary et al. "Genetic and epigenetic architectures of neurological protein biomarkers in the Lothian Birth Cohort 1936" (In submission). Specifically GWAS proteins.