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Martin O'Donnell
National University of Ireland, Galway
Publications 236
Published on Jan 8, 2019in Systematic Reviews
Francesca Wuytack6
Estimated H-index: 6
(Trinity College, Dublin),
Maria Regan (National University of Ireland, Galway)+ 5 AuthorsDeclan Devane29
Estimated H-index: 29
(National University of Ireland, Galway)
MR was supported by a Health Research Board (Ireland)—Trials Methodology Research Network Summer Student Scholarship.
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Published on Mar 1, 2019in Journal of Stroke & Cerebrovascular Diseases 1.60
Conor Judge (Wellcome Trust), Sarah Ruttledge (National University of Ireland, Galway)+ 9 AuthorsMichelle Canavan7
Estimated H-index: 7
(National University of Ireland, Galway)
Abstract Background: The association of lipid lowering therapy and intracerebral hemorrhage risk is controversial. Methods: We performed a cumulative meta-analysis of lipid lowering trials that reported intracerebral hemorrhage. Statin, fibrate, ezetimibe, PCSK9, and CETP trials were included. We explored whether the association of lipid lowering therapy and risk of intracerebral hemorrhage may vary by baseline low-density lipoprotein (LDL) level, mean change in LDL or baseline cardiovascular ri...
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Published on May 1, 2019in Gastroenterology 20.77
Paul Moayyedi81
Estimated H-index: 81
John W. Eikelboom89
Estimated H-index: 89
+ 47 AuthorsKelley R. Branch20
Estimated H-index: 20
Abstract Background & Aims Antiplatelet and anticoagulants are associated with increased upper gastrointestinal bleeding. We evaluated whether proton pump inhibitor therapy could reduce this risk. Methods We performed a 3x2 partial factorial double-blind trial of 17,598 participants with stable cardiovascular disease and peripheral artery disease. Participants were randomly assigned to groups given pantoprazole 40 mg daily or placebo, as well as rivaroxaban 2.5 mg twice daily with aspirin 100 mg...
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Published on Apr 1, 2019in International Journal of Stroke 3.86
Mukul Sharma25
Estimated H-index: 25
(Population Health Research Institute),
Robert G. Hart19
Estimated H-index: 19
(Population Health Research Institute)
+ 35 AuthorsRafael Diaz71
Estimated H-index: 71
(McMaster University)
BackgroundCovert vascular disease of the brain manifests as infarcts, white matter hyperintensities, and microbleeds on MRI. Their cumulative effect is often a decline in cognition, motor impairment, and psychiatric disorders. Preventive therapies for covert brain ischemia have not been established but represent a huge unmet clinical need.AimsThe MRI substudy examines the effects of the antithrombotic regimens in COMPASS on incident covert brain infarcts (the primary outcome), white matter hyper...
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Published on Mar 29, 2019in Disability and Rehabilitation 2.04
Vincent G. DePaul7
Estimated H-index: 7
(Queen's University),
Jackie Bosch43
Estimated H-index: 43
(McMaster University)
+ 3 AuthorsRobert G. Hart85
Estimated H-index: 85
(McMaster University)
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Published on Mar 26, 2019in Neurology 8.05
Jackie Bosch43
Estimated H-index: 43
Martin O'Donnell50
Estimated H-index: 50
+ 18 AuthorsAlvaro Avezum70
Estimated H-index: 70
Objective To assess whether long-term treatment with candesartan/hydrochlorothiazide, rosuvastatin, or their combination can slow cognitive decline in older people at intermediate cardiovascular risk. Methods The Heart Outcomes Prevention Evaluation-3 (HOPE-3) study was a double-blind, randomized, placebo-controlled clinical trial using a 2 × 2 factorial design. Participants without known cardiovascular disease or need for treatment were randomized to candesartan (16 mg) plus hydrochlorothiazide...
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