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Martin O'Donnell
Hamilton Health Sciences
269Publications
54H-index
39.9kCitations
Publications 269
Newest
#1John Ferguson (National University of Ireland, Galway)H-Index: 8
#2Neil O’Leary (National University of Ireland, Galway)H-Index: 2
Last.Martin O'Donnell (National University of Ireland, Galway)H-Index: 54
view all 5 authors...
Background Population attributable fractions (PAF) measure the proportion of disease prevalence that would be avoided in a hypothetical population, similar to the population of interest, but where a particular risk factor is eliminated. They are extensively used in epidemiology to quantify and compare disease burden due to various risk factors, and directly influence public policy regarding possible health interventions. In contrast to individual specific metrics such as relative risks and odds ...
Source
#1Francesca Wuytack (Trinity College, Dublin)H-Index: 6
#2Maria Regan (National University of Ireland, Galway)
Last.Declan Devane (National University of Ireland, Galway)H-Index: 30
view all 8 authors...
Systematic reviews of randomised trials guide policy and healthcare decisions. Yet, we observed that some reviews judge randomised trials as high or unclear risk of bias (ROB) for sequence generation, potentially introducing bias. However, to date, the extent of this issue has not been well examined. We evaluated the consistency in the ROB assessment for sequence generation of randomised trials in Cochrane and non-Cochrane reviews, and explored the reviewers’ judgement of the quality of evidence...
Source
#1John W. Eikelboom (Population Health Research Institute)H-Index: 93
#2Stuart J. Connolly (Population Health Research Institute)H-Index: 56
Last.Salim Yusuf Mb Bs DPhil Frcpc (Population Health Research Institute)H-Index: 214
view all 22 authors...
Background: Patients treated with antithrombotic drugs are at risk of bleeding. Bleeding may be the first manifestation of underlying cancer. Methods: We examined new cancers diagnosed in relation ...
2 CitationsSource
#1Catriona Reddin (University Hospital Galway)
#2Robert Murphy (University Hospital Galway)
Last.Michelle Canavan (University Hospital Galway)H-Index: 9
view all 14 authors...
Source
#1Robert Murphy (National University of Ireland, Galway)H-Index: 1
#2Catriona Reddin (National University of Ireland, Galway)H-Index: 2
Last.Michelle Canavan (National University of Ireland, Galway)H-Index: 9
view all 14 authors...
Source
#1Salim Yusuf Mb Bs DPhil Frcpc (Population Health Research Institute)H-Index: 214
#2Philip Joseph (Population Health Research Institute)H-Index: 17
Last.Gilles Dagenais (Laval University)H-Index: 31
view all 39 authors...
Summary Background Global estimates of the effect of common modifiable risk factors on cardiovascular disease and mortality are largely based on data from separate studies, using different methodologies. The Prospective Urban Rural Epidemiology (PURE) study overcomes these limitations by using similar methods to prospectively measure the effect of modifiable risk factors on cardiovascular disease and mortality across 21 countries (spanning five continents) grouped by different economic levels. M...
4 CitationsSource
#1Paul Moayyedi (Population Health Research Institute)H-Index: 3
#2John W. Eikelboom (Population Health Research Institute)H-Index: 93
Last.Salim Yusuf Mb Bs DPhil Frcpc (Population Health Research Institute)H-Index: 214
view all 50 authors...
Background & Aims Proton pump inhibitors (PPIs) are effective at treating acid-related disorders. These drugs are well tolerated in the short term, but long-term treatment was associated with adverse events in observational studies. We aimed to confirm these findings in an adequately powered randomized trial. Methods We performed a 3 × 2 partial factorial double-blind trial of 17,598 participants with stable cardiovascular disease and peripheral artery disease randomly assigned to groups given p...
9 CitationsSource
#1John W. Eikelboom (HHS: Hamilton Health Sciences)H-Index: 93
#2Jacqueline Bosch (McMaster University)H-Index: 2
Last.Salim Yusuf Mb Bs DPhil Frcpc (HHS: Hamilton Health Sciences)H-Index: 214
view all 18 authors...
Abstract Background In patients with coronary or peripheral artery disease, the combination of rivaroxaban 2.5 mg twice daily and aspirin 100 mg once daily compared with aspirin 100 mg once daily reduced major adverse cardiovascular events and mortality and increased bleeding. Objectives This study sought to explore the effects of the combination of rivaroxaban and aspirin compared with aspirin on sites, timing, severity, and management of bleeding in the COMPASS (Cardiovascular Outcomes for Peo...
1 CitationsSource
#1Andrew Mente (Population Health Research Institute)H-Index: 32
#2Martin O'Donnell (National University of Ireland, Galway)H-Index: 54
Last.Salim Yusuf Mb Bs DPhil Frcpc (Population Health Research Institute)H-Index: 214
view all 3 authors...
Source
#1Paul Moayyedi (Population Health Research Institute)H-Index: 3
#2John W. Eikelboom (Population Health Research Institute)H-Index: 93
Last.Salim Yusuf Mb Bs DPhil Frcpc (Population Health Research Institute)H-Index: 214
view all 50 authors...
Background & Aims Antiplatelets and anticoagulants are associated with increased upper gastrointestinal bleeding. We evaluated whether proton pump inhibitor therapy could reduce this risk. Methods We performed a 3 × 2 partial factorial double-blind trial of 17,598 participants with stable cardiovascular disease and peripheral artery disease. Participants were randomly assigned to groups given pantoprazole 40 mg daily or placebo, as well as rivaroxaban 2.5 mg twice daily with aspirin 100 mg once ...
3 CitationsSource
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