Paula Amato
Oregon Health & Science University
40Publications
20H-index
2,098Citations
Publications 40
Newest
Published on Mar 1, 2019in Nature 41.58
Eunju Kang13
Estimated H-index: 13
(Oregon National Primate Research Center),
Jun Wu28
Estimated H-index: 28
(Salk Institute for Biological Studies)
+ 27 AuthorsYeonmi Lee6
Estimated H-index: 6
(Oregon National Primate Research Center)
Change history In this Letter, there are several errors regarding the assignments of mtDNA haplotypes for a subset of egg donors from our study. These errors have not been corrected online.
Source Cite
Published on Sep 1, 2018in Fertility and Sterility 4.80
M. Siegel , Paula Amato20
Estimated H-index: 20
+ 2 AuthorsSacha Krieg11
Estimated H-index: 11
Source Cite
Published on Jan 1, 2017in Cell Stem Cell 23.29
Hong Ma27
Estimated H-index: 27
(Oregon Health & Science University),
Ryan C. O’Neil4
Estimated H-index: 4
(University of California, San Diego)
+ 23 AuthorsYeonmi Lee6
Estimated H-index: 6
(Oregon Health & Science University)
Summary Oocyte defects lie at the heart of some forms of infertility and could potentially be addressed therapeutically by alternative routes for oocyte formation. Here, we describe the generation of functional human oocytes following nuclear transfer of first polar body (PB1) genomes from metaphase II (MII) oocytes into enucleated donor MII cytoplasm (PBNT). The reconstructed oocytes supported the formation of de novo meiotic spindles and, after fertilization with sperm, meiosis completion and ...
18 Citations Source Cite
Published on Aug 1, 2017in Nature 41.58
Hong Ma27
Estimated H-index: 27
(Oregon National Primate Research Center),
Nuria Marti-Gutierrez1
Estimated H-index: 1
(Oregon Health & Science University)
+ 28 AuthorsRiffat Ahmed10
Estimated H-index: 10
(Oregon Health & Science University)
Genome editing could be applied to correct disease-causing mutations in human embryos, but concerns about efficacy and safety are paramount. Shoukhrat Mitalipov and colleagues use CRISPRCas9 to correct a heritable cardiomyopathy mutation in human embryos. By optimizing the experimental conditions, the authors show very reduced mosaicism, and report that for this heterozygous mutation, CRISPRCas9-induced breaks seem to be preferentially repaired using the wild-type allele as a template in human e...
238 Citations Source Cite
Published on Nov 30, 2016in Nature 41.58
Eunju Kang13
Estimated H-index: 13
(University of Ulsan),
Jun Wu28
Estimated H-index: 28
(Salk Institute for Biological Studies)
+ 27 AuthorsYeonmi Lee6
Estimated H-index: 6
(Oregon Health & Science University)
Analysis of mitochondrial replacement therapy shows, even with efficient mutant mitochondrial DNA replacement and maintenance in embryonic stem cells, a gradual loss of donor mitochondrial DNA in some lines owing to a polymorphism in the D-loop, potentially causing preferential replication of specific mitochondrial DNA haplotypes.
59 Citations Source Cite
Published on May 1, 2016in Cell Stem Cell 23.29
Eunju Kang13
Estimated H-index: 13
(Oregon National Primate Research Center),
Xinjian Wang3
Estimated H-index: 3
(Cincinnati Children's Hospital Medical Center)
+ 20 AuthorsYing Li14
Estimated H-index: 14
(Oregon National Primate Research Center)
Summary The genetic integrity of iPSCs is an important consideration for therapeutic application. In this study, we examine the accumulation of somatic mitochondrial genome (mtDNA) mutations in skin fibroblasts, blood, and iPSCs derived from young and elderly subjects (24–72 years). We found that pooled skin and blood mtDNA contained low heteroplasmic point mutations, but a panel of ten individual iPSC lines from each tissue or clonally expanded fibroblasts carried an elevated load of heteroplas...
70 Citations Source Cite
Published on Sep 1, 2015in Mitochondrion 3.23
Amy Koski5
Estimated H-index: 5
(Oregon Health & Science University),
Hong Ma27
Estimated H-index: 27
(Oregon Health & Science University)
+ 23 AuthorsXinjian Wang17
Estimated H-index: 17
(Cincinnati Children's Hospital Medical Center)
Source Cite
Published on Aug 1, 2015in Nature 41.58
Hong Ma27
Estimated H-index: 27
(Oregon National Primate Research Center),
Clifford D.L. Folmes16
Estimated H-index: 16
(Mayo Clinic)
+ 23 AuthorsRiffat Ahmed10
Estimated H-index: 10
(Oregon Health & Science University)
Mutations in mitochondrial (mt)DNA are associated with severe disorders for which treatment is currently limited; this study shows that mtDNA mutations can be genetically corrected and normal metabolic function restored in cells derived from patients with mtDNA disease and reprogrammed to pluripotency through factor-mediated reprogramming or via a somatic cell nuclear transfer approach.
75 Citations Source Cite
Published on Feb 1, 2014in American Journal of Preventive Medicine 4.13
Megan Bair-Merritt9
Estimated H-index: 9
(Boston University),
Annie Lewis-O’Connor6
Estimated H-index: 6
(Harvard University)
+ 5 AuthorsPeter F. Cronholm20
Estimated H-index: 20
(University of Pennsylvania)
Context Primary care providers are uniquely positioned to respond to patients' disclosure of intimate partner violence (IPV). However, the research on primary care–based IPV interventions has not been systematically synthesized, making it difficult for providers, policymakers, and researchers to understand how to effectively intervene in the primary care setting. This systematic review summarizes primary care–based interventions for patients experiencing IPV. Evidence acquisition PubMed, PsycINF...
70 Citations Source Cite
Published on Jan 1, 2014in Fertility and Sterility 4.80
Paula Amato20
Estimated H-index: 20
(Oregon Health & Science University),
Masahito Tachibana14
Estimated H-index: 14
+ 1 AuthorsShoukhrat Mitalipov36
Estimated H-index: 36
(Oregon National Primate Research Center)
The exchange of nuclear genetic material between oocytes and embryos offers a novel reproductive option for the prevention of inherited mitochondrial diseases. Mitochondrial dysfunction has been recognized as a significant cause of a number of serious multiorgan diseases. Tissues with a high metabolic demand, such as brain, heart, muscle, and central nervous system, are often affected. Mitochondrial disease can be due to mutations in mitochondrial DNA or in nuclear genes involved in mitochondria...
51 Citations Source Cite
1234