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Martin Krøyer Rasmussen
Aarhus University
66Publications
15H-index
691Citations
Publications 66
Newest
#1Martin Krøyer Rasmussen (DTU: Technical University of Denmark)H-Index: 15
#2Nikolay KardjilovH-Index: 34
Last.Heloisa N. Bordallo (UCPH: University of Copenhagen)H-Index: 15
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Developing a technology that enables oral vaccines to work efficiently remains a considerable effort since a number of difficulties must be addressed. The key objective being to ensure the safe passage through the harsh conditions within the gastrointestinal tract, promoting delivery that induces enhanced immune response. In the particular case of hepatitis B, the oral formulation in the nanostructured silica SBA-15 is a viable approach. As a result of its porous structure, low toxicity and stru...
#1J.L.S. Lopes (USP: University of São Paulo)
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Abstract Hepatitis B virus causes acute and chronic infections in millions of people worldwide and, since 1982, a vaccine with 95% effectiveness has been available for immunization. The main component of the recombinant hepatitis B vaccine is the surface antigen protein (HBsAg). In this work, the effect of pH, ionic strength and temperature on the native state of the HBsAg antigen were studied by a combination of biophysical methods that included small angle X-ray scattering, synchrotron radiati...
#1Martin Krøyer Rasmussen (AU: Aarhus University)H-Index: 15
#2Carsten Scarvenius (AU: Aarhus University)
Last.Jan J. Enghild (AU: Aarhus University)H-Index: 57
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Abstract The cytochrome P450 enzyme (CYP) family includes key enzymes for the metabolism of drugs and xenobiotics. Several animal models have been used to determine the metabolite profile of specific drugs. Among these are porcine microsomes prepared from Gottingen minipigs. However, CYP expression profile in microsomes from this pig breed is unknown. In the present study, we determined the mRNA and protein profiles of a comprehensive selection of CYPs in microsomes prepared from male and female...
#1Niels Oksbjerg (AU: Aarhus University)H-Index: 29
#2U. Krogh (AU: Aarhus University)H-Index: 7
Last.P. K. Theil (AU: Aarhus University)H-Index: 24
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Abstract This study investigated the effect of dietary inclusion of 25 g/day of L -Arginine ( n = 7) or iso‑nitrogenous amounts of alanine ( n = 6) from d 30 of gestation to d 28 of lactation of sows on performance, muscle traits and meat quality in offspring. From each litter, heaviest and smallest littermate of both sexes were reared from d 28 and slaughtered at d 140 in accordance with a 2 3 factorial design. A response to L -Arginine were obtained on small females where L -Arginine increased...
#1Martin Krøyer Rasmussen (UCPH: University of Copenhagen)H-Index: 15
#2Jose E. M. Pereira (UCPH: University of Copenhagen)H-Index: 2
Last.Heloisa N. Bordallo (UCPH: University of Copenhagen)H-Index: 15
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As a consequence of its ordered pore architecture, mesoporous SBA-15 offers new possibilities for incorporating biological agents. Considering its applicability in oral vaccination, which shows more beneficial features when compared with parenteral vaccines, SBA-15 is also seen as a very promising adjuvant to carry, protect, and deliver entrapped antigens. Recent studies have shown several remarkable features in the immunization of hepatitis B, a viral disease transmitted mainly through blood or...
#1Viktoriia Burkina (Sewanee: The University of the South)H-Index: 8
#2Vladimir Zlabek (Sewanee: The University of the South)H-Index: 20
Last.Galia Zamaratskaia (Sewanee: The University of the South)H-Index: 25
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Abstract The hepatic cytochrome p450 enzymes 1 A, 2A19 and 2E1 is very important for the elimination of skatole from the body of pigs. Impaired skatole metabolism, results in skatole accumulation, which give rise to off flavor of the meat. Several metabolites of skatole has been identified, however the role of these metabolites in the inhibition of the skatole metabolizing enzymes are not documented. Using microsomes from pigs and fish, we determined the ability of several skatole metabolites to...
#1Viktoriia Burkina (Sewanee: The University of the South)H-Index: 8
#2Martin Krøyer Rasmussen (AU: Aarhus University)H-Index: 15
Last.Galia Zamaratskaia (Sewanee: The University of the South)H-Index: 25
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#1Sidika Sakalli (Sewanee: The University of the South)H-Index: 3
#2Pham Thai Giang (Sewanee: The University of the South)H-Index: 2
Last.Vladimir Zlabek (Sewanee: The University of the South)H-Index: 20
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Abstract Sewage treatment plants (STPs) are one of the major source of pharmaceuticals and personal care products in the aquatic environment. Generally, the effects of individual chemicals on fish are studied under laboratory conditions, which leads to results that are potentially not realistic regarding the effects of these chemicals under environmental conditions. Therefore, in this study, common carps were held in exposed pond that receive water from STP effluents for 360 days under natural c...
#1Rebekka Thøgersen (AU: Aarhus University)H-Index: 2
#2Bjørn Petrat-Melin (AU: Aarhus University)H-Index: 4
Last.Martin Krøyer Rasmussen (AU: Aarhus University)H-Index: 15
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Abstract The physiological effects of the Stevia-derived compounds, rebaudioside A, stevioside and steviol have been the focus of several studies due to their use as sweeteners in food. Despite that, little is known about their potential food-drug interactions. In the present study, IPEC-J2 cells and primary hepatocytes were used to investigate the effect of rebaudioside A, stevioside and steviol on cytochrome p450 (CYP) mRNA expression. Moreover, hepatic microsomes were used to investigate dire...
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