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Silvia Hayer
Medical University of Vienna
ImmunologyInflammationArthritisRheumatoid arthritisMedicine
96Publications
28H-index
2,873Citations
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Publications 95
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#1Cleo Rogier (EUR: Erasmus University Rotterdam)H-Index: 1
#2Silvia Hayer (Medical University of Vienna)H-Index: 28
Last. Annette H. M. van der Helm-van Mil (EUR: Erasmus University Rotterdam)H-Index: 46
view all 3 authors...
Rheumatoid arthritis (RA) is typically represented as synovitis and bone erosions of small joints. This classic picture resulted from comparing patients with RA with other rheumatic joint diseases for clinical and radiographic characteristics. Although different classification criteria for RA have been developed over time, this classic picture has not changed since the mid-20th century. During the last decennium, advanced imaging modalities, such as MRI and musculoskeletal ultrasound (US), have ...
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#1V Saferding (Medical University of Vienna)H-Index: 6
#2M Hofmann (Medical University of Vienna)H-Index: 2
Last. Richard StangeH-Index: 15
view all 17 authors...
Bone loss is one of the consequences of aging, leading to diseases such as osteoporosis and increased susceptibility to fragility fractures and therefore considerable morbidity and mortality in humans. Here we identify microRNA 146a as an essential epigenetic switch controlling bone loss with age. Mice deficient in miR-146a show regular development of their skeleton. However, while WT mice start to lose bone with age, animals deficient in miR-146a continue to accrue bone throughout their life sp...
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#1Silvia Hayer (Medical University of Vienna)H-Index: 28
#2Markus Zeilinger (University of Applied Sciences Wiener Neustadt)H-Index: 5
Last. Markus Mitterhauser (Medical University of Vienna)H-Index: 29
view all 15 authors...
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#1Michael Bonelli (Medical University of Vienna)H-Index: 19
#2K Dalwigk (Medical University of Vienna)H-Index: 5
Last. Thomas Karonitsch (Medical University of Vienna)H-Index: 15
view all 14 authors...
Rheumatoid arthritis (RA) is an autoimmune disease characterized by persistent synovial inflammation. The major drivers of synovial inflammation are cytokines and chemokines. Among these molecules, TNF activates fibroblast-like synoviocytes (FLSs), which leads to the production of inflammatory mediators. Here, we show that TNF regulates the expression of the transcription factor interferon regulatory factor 1 (IRF1) in human FLSs as well as in a TNF transgenic arthritis mouse model. Transcriptom...
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#1Michael BonelliH-Index: 19
#2K DalwigkH-Index: 5
Last. Thomas KaronitschH-Index: 15
view all 14 authors...
Career situation of first and presenting author Young investigator. Introduction Rheumatoid arthritis (RA) is an autoimmune disease, which is characterized by persistent, synovial inflammation. Major drivers of synovial inflammation are cytokines and chemokines. Among them TNF activates fibroblast-like synoviocytes (FLS), which leads to the production of inflammatory mediators. The pathways and transcription factors that determine the inflammatory response in FLS are largely unexplored. Here, we...
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#1V Saferding (Medical University of Vienna)H-Index: 6
#2M Hofmann (Medical University of Vienna)H-Index: 2
Last. Stephan Blüml (Medical University of Vienna)H-Index: 19
view all 10 authors...
Career situation of first and presenting author Post-doctoral fellow. Introduction Micro RNAs (miRNAs) play a crucial role in the regulation of bone metabolism. MiR-146a, an important anti-inflammatory miRNA, was found to negatively impact osteogenesis and bone regeneration in vitro , by controlling the differentiation of mesenchymal stem cells. But to date the role of miR-146a in bone remodelling, its influence on bone stability and development of osteoporosis is not known. Objectives Our aim i...
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#1K Wanic (Medical University of Vienna)
#3M Kalkgruber (Medical University of Vienna)
Last. Silvia Hayer (Medical University of Vienna)H-Index: 28
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Career situation of first and presenting author Student for a master or a PhD. Introduction Partial bone repair upon treatment with biological DMARDs has been reported in patients with Rheumatoid Arthritis (RA). Previous in vivo PET/CT studies using the human tumor necrosis factor transgenic mouse model (hTNFtg) have been demonstrated the reversibility of pre-existing inflammatory, erosive arthritis with complete remission of synovial inflammation and repair of bone erosions upon TNF blockade. O...
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#1Michael Bonelli (Medical University of Vienna)H-Index: 19
#2Antonia Puchner (Medical University of Vienna)H-Index: 7
Last. Stephan Blüml (Medical University of Vienna)H-Index: 19
view all 13 authors...
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#1Antonia Puchner (Medical University of Vienna)H-Index: 7
#2V Saferding (Medical University of Vienna)H-Index: 6
Last. Stephan Blüml (Medical University of Vienna)H-Index: 19
view all 23 authors...
Objectives Bone destruction in rheumatoid arthritis is mediated by osteoclasts (OC), which are derived from precursor cells of the myeloid lineage. The role of the two monocyte subsets, classical monocytes (expressing CD115, Ly6C and CCR2) and non-classical monocytes (which are CD115 positive, but low in Ly6C and CCR2), in serving as precursors for OC in arthritis is still elusive. Methods We investigated CCR2 −/− mice, which lack circulating classical monocytes, crossed into hTNFtg mice for the...
7 CitationsSource
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