Yoshihiko Nishio
Kagoshima University
Publications 158
#1Kiyoaki Yamamoto (Kadai: Kagoshima University)H-Index: 2
#2Takashi Ito (Kadai: Kagoshima University)H-Index: 1
Last.Ikuro Maruyama (Kadai: Kagoshima University)H-Index: 47
view all 11 authors...
Thrombus formation is an important factor affecting cardiovascular events and venous thromboembolism in type 2 diabetes. However, it is unclear whether glycemic control reduces thrombogenicity. We investigated the effect of short-term glycemic control (STUDY 1) and hypoglycemia (STUDY 2) on thrombus formation using an automated microchip flow chamber system. For STUDY 1, we recruited 10 patients with type 2 diabetes. Before and after 2 weeks of treatment, blood glucose was analyzed with a contin...
#1Shinji Kume (Shiga University of Medical Science)H-Index: 29
#2Shin-ichi Araki (Shiga University of Medical Science)H-Index: 38
Last.Hiroshi Maegawa (Shiga University of Medical Science)H-Index: 46
view all 9 authors...
#1Sahar Ghavidel Darestani (Kadai: Kagoshima University)H-Index: 1
#2Mihoko Kurano (Kadai: Kagoshima University)H-Index: 2
Last.Akira Kikuchi (Kadai: Kagoshima University)H-Index: 1
view all 13 authors...
Introduction Several studies have recently pointed out the role of many inflammatory mediators in the progression of diabetes complications. We had previously demonstrated that mRNA expression of platelet-activating factor receptor (PAFR) in peripheral blood mononuclear cells (PBMCs) was associated with urinary albumin to creatinine ratio (ACR) and forearm flow-mediated dilatation in patients with type 2 diabetes. In an attempt to elucidate this association, patients were followed up for 1 year.
#1Kazuma Ogiso (Kadai: Kagoshima University)H-Index: 4
#2Nobuyuki KoriyamaH-Index: 1
Last.Yoshihiko Nishio (Kadai: Kagoshima University)H-Index: 39
view all 6 authors...
Background Most previous insulin infusion protocols are titrated for Westerners and are not simple to follow. In this study, we tested the efficacy and safety of our simple insulin infusion protocol utilizing lower insulin doses for Asians.
#1Mihoko Kurano (Kadai: Kagoshima University)H-Index: 2
#2Sahar Ghavidel Darestani (Kadai: Kagoshima University)H-Index: 1
Last.Takahisa Deguchi (Kadai: Kagoshima University)H-Index: 5
view all 11 authors...
Abstract Aims Renal dysfunction in addition to diabetes is a serious risk factor for cardiovascular events. We hypothesized that some of the changes in gene expression in blood cells cause renal dysfunction and macrovascular disease through impaired endothelial function. This study aimed to define which changes in gene expression in peripheral blood mononuclear cells (PBMCs) are related to renal function parameters and endothelial function of large arteries in patients with type 2 diabetes melli...
#1Teruaki MasudaH-Index: 5
#2Mitsuharu UedaH-Index: 23
Last.Sayaka MatsumotoH-Index: 3
view all 18 authors...
Objective: To elucidate early skin denervation in hereditary transthyretin (TTR) amyloidosis and iatrogenic TTR amyloidosis. Methods: We investigated intraepidermal nerve fiber density (IENFD) and clinical findings in 32 patients with hereditary TTR amyloidosis, 11 asymptomatic mutation carriers, 6 patients with iatrogenic TTR amyloidosis, and 23 healthy volunteers. Results: IENFD values were reduced in patients with the V30M mutation (1.9 ± 2.1 per 1 mm), patients with non-V30M mutations (5.8 ±...
#1Atsushi Tanaka (Saga University)H-Index: 13
#2Toyoaki Murohara (Nagoya University)H-Index: 79
Last.Hirotsugu Yamada (University of Tokushima)H-Index: 33
view all 26 authors...
Background Type 2 diabetes mellitus is associated strongly with an increased risk of micro- and macro-vascular complications, leading to impaired quality of life and shortened life expectancy. In addition to appropriate glycemic control, multi-factorial intervention for a wide range of risk factors, such as hypertension and dyslipidemia, is crucial for management of diabetes. A recent cardiovascular outcome trial in diabetes patients with higher cardiovascular risk demonstrated that a SGLT2 inhi...
#1Shinji Kume (Shiga University of Medical Science)H-Index: 29
#2Motoyuki Kondo (Shiga University of Medical Science)H-Index: 9
Last.Shin-ich Araki (Shiga University of Medical Science)H-Index: 1
view all 19 authors...
Abstract Glucose-stimulated insulin secretion (GSIS) by pancreatic β cells is biphasic. However, the physiological significance of biphasic GSIS and its relationship to diabetes are not yet fully understood. This study demonstrated that impaired first-phase GSIS follows fasting, leading to increased blood glucose levels and brain glucose distribution in humans. Animal experiments to determine a possible network between the brain and β cells revealed that fasting-dependent hyperactivation of AMP-...