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Michael Toft Overgaard
Aalborg University
EndocrinologyMolecular biologyPregnancy-associated plasma protein ABiochemistryBiology
128Publications
42H-index
5,828Citations
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Publications 137
Newest
Last. Ivy E. DickH-Index: 14
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#1C. HoltH-Index: 2
Last. Reinhard WimmerH-Index: 25
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#1C. HoltH-Index: 2
Last. Reinhard WimmerH-Index: 25
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#1Kelvin LauH-Index: 10
Last. Reinhard WimmerH-Index: 25
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#1Kelvin LauH-Index: 10
Last. Reinhard WimmerH-Index: 25
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#1C. Holt (AAU: Aalborg University)H-Index: 2
#2Louise Hamborg (AAU: Aalborg University)
Last. Reinhard Wimmer (AAU: Aalborg University)H-Index: 25
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Mutations in the genes encoding the highly conserved Ca(2+)-sensing protein calmodulin (CaM) cause severe cardiac arrhythmias, including catecholaminergic polymorphic ventricular tachycardia (CPVT) or long QT syndrome, and sudden cardiac death. Most of the identified arrhythmogenic mutations reside in the C-terminal domain of CaM, and mostly affect Ca(2+)-coordinating residues. One exception is the CPVT-causing N53I substitution, which resides in the N-terminal domain (N-domain). It does not aff...
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#1Pedro J. García-Moreno (DTU: Technical University of Denmark)H-Index: 12
#2Charlotte Jacobsen (DTU: Technical University of Denmark)H-Index: 41
Last. Egon Bech (DTU: Technical University of Denmark)H-Index: 21
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Abstract This work investigated the use of bioinformatics to predict emulsifying peptides embedded in patatin proteins from potato (Solanum tuberosum). Six peptides (23–29 amino acids) with potentially different predominant structure at the oil/water interface (e.g. α-helix, β-strand or unordered) were identified within patatin sequences. The interfacial tension between peptides solutions and fish oil as well as the physical and oxidative stability of 5 wt% fish oil-in-water emulsions (pH 7) sta...
1 CitationsSource
#1Ole Fröbert (Örebro University)H-Index: 26
Last. Michael Toft OvergaardH-Index: 42
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Sedentary lifestyle accelerates biological ageing, is a major risk factor for developing metabolic syndrome and is associated with cardiovascular disease, diabetes mellitus, kidney failure, sarcopenia and osteoporosis. In contrast to the linear path to worsening health in humans with metabolic syndrome, brown bears have developed a circular metabolic plasticity enabling these animals to tolerate obesity and a 'sedentary lifestyle' during hibernation and exit the den metabolically healthy in spri...
2 CitationsSource
#1K. WangH-Index: 1
#2Malene Brohus (AAU: Aalborg University)H-Index: 3
Last. Filip Van PetegemH-Index: 26
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KEY POINTS: Mutations in the calmodulin protein (CaM) are associated with arrhythmia syndromes. This study focuses on understanding the structural characteristics of CaM disease mutants and their interactions with the voltage-gated calcium channel CaV 1.2. Arrhythmia mutations in CaM can lead to loss of Ca(2+) binding, uncoupling of Ca(2+) binding cooperativity, misfolding of the EF-hands and altered affinity for the calcium channel. These results help us to understand how different CaM mutants ...
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#2Helene H. JensenH-Index: 6
Last. Ivy E. DickH-Index: 14
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