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Thomas D. Schneider
National Institutes of Health
108Publications
39H-index
8,676Citations
Publications 108
Newest
Published on May 7, 2019in Nucleic Acids Research 11.56
Zhe Sun1
Estimated H-index: 1
(National Institutes of Health),
Cedric Cagliero7
Estimated H-index: 7
(National Institutes of Health)
+ 5 AuthorsDing Jun Jin11
Estimated H-index: 11
(National Institutes of Health)
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Published on Jan 1, 2019in arXiv: Quantitative Methods
Thomas D. Schneider39
Estimated H-index: 39
(National Institutes of Health),
Vishnu Jejjala8
Estimated H-index: 8
(University of the Witwatersrand)
Restriction enzymes recognize and bind to specific sequences on invading bacteriophage DNA. Like a key in a lock, these proteins require many contacts to specify the correct DNA sequence. Using information theory we develop an equation that defines the number of independent contacts, which is the dimensionality of the binding. We show that EcoRI, which binds to the sequence GAATTC, functions in 24 dimensions. Information theory represents messages as spheres in high dimensional spaces. Better sp...
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Published on Jan 16, 2018in Journal of Bacteriology 3.22
Katherine J. Fenstermacher1
Estimated H-index: 1
(University of Maryland, College Park),
Vasudevan Achuthan3
Estimated H-index: 3
(University of Maryland, College Park)
+ 1 AuthorsJeffrey J. DeStefano20
Estimated H-index: 20
(University of Maryland, College Park)
ABSTRACT DNA polymerases (DNAPs) recognize 3′ recessed termini on duplex DNA and carry out nucleotide catalysis. Unlike promoter-specific RNA polymerases (RNAPs), no sequence specificity is required for binding or initiation of catalysis. Despite this, previous results indicate that viral reverse transcriptases bind much more tightly to DNA primers that mimic the polypurine tract. In the current report, primer sequences that bind with high affinity to Taq and Klenow polymerases were identified u...
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Published on Nov 16, 2016in Frontiers in Molecular Biosciences
Zhong Qian3
Estimated H-index: 3
(Laboratory of Molecular Biology),
Andrei Trostel6
Estimated H-index: 6
(Laboratory of Molecular Biology)
+ 7 AuthorsSankar Adhya55
Estimated H-index: 55
(Laboratory of Molecular Biology)
The regulatory protein, GalR, is known for controlling transcription of genes related to D-galactose metabolism in Escherichia coli. Here, using a combination of experimental and bioinformatic approaches, we identify novel GalR binding sites upstream of several genes whose function is not directly related to D-galactose metabolism. Moreover, we do not observe regulation of these genes by GalR under standard growth conditions. Thus, our data indicate a broader regulatory role for GalR, and sugges...
3 Citations Source Cite
Airlie J. McCoy34
Estimated H-index: 34
(University of Cambridge),
Thomas D. Schneider39
Estimated H-index: 39
This issue publishes the proceedings of the 2015 CCP4 Study Weekend on Advances in Experimental Phasing, held on 8–9 January 2015 at the East Midlands Conference Centre of the University of Nottingham, UK. Crystallographic phasing using experimental approaches remains an important, and often the only successful, route for solving crystal structures, especially for structures with novel folds. These are often large and complex assemblies diffracting to limited resolution, but also those likely to...
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Published on Aug 26, 2015in PLOS ONE 2.77
Kristen M. Pluchino8
Estimated H-index: 8
(National Institutes of Health),
Dominic Esposito19
Estimated H-index: 19
(Leidos)
+ 11 AuthorsIan A. Pringle16
Estimated H-index: 16
(University of Oxford)
The efflux transporter P-glycoprotein (P-gp) is an important mediator of various pharmacokinetic parameters, being expressed at numerous physiological barriers and also in multidrug-resistant cancer cells. Molecular cloning of homologous cDNAs is an important tool for the characterization of functional differences in P-gp between species. However, plasmids containing mouse mdr1a cDNA display significant genetic instability during cloning in bacteria, indicating that mdr1a cDNA may be somehow tox...
5 Citations Source Cite
Thomas D. Schneider39
Estimated H-index: 39
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Thomas D. Schneider39
Estimated H-index: 39
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Thomas D. Schneider39
Estimated H-index: 39
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Thomas D. Schneider39
Estimated H-index: 39
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