Andrew M. McIntosh
University of Edinburgh
Publications 624
#1Yanni Zeng (Edin.: University of Edinburgh)H-Index: 6
#2Carmen Amador (Edin.: University of Edinburgh)H-Index: 7
Last.Chris Haley (Edin.: University of Edinburgh)H-Index: 59
view all 23 authors...
Parent-of-origin effects (POE) exist when there is differential expression of alleles inherited from the two parents. A genome-wide scan for POE on DNA methylation at 639,238 CpGs in 5,101 individuals identifies 733 independent methylation CpGs potentially influenced by POE at a false discovery rate ≤ 0.05 of which 331 had not previously been identified. Cis and trans methylation quantitative trait loci (mQTL) regulate methylation variation through POE at 54% (399/733) of the identified POE-infl...
#1Emanuel Schwarz (Heidelberg University)H-Index: 10
#2Nhat Trung Doan (University of Oslo)H-Index: 18
Last.Andreas Meyer-Lindenberg (Heidelberg University)H-Index: 88
view all 38 authors...
Schizophrenia is a severe mental disorder characterized by numerous subtle changes in brain structure and function. Machine learning allows exploring the utility of combining structural and functional brain magnetic resonance imaging (MRI) measures for diagnostic application, but this approach has been hampered by sample size limitations and lack of differential diagnostic data. Here, we performed a multi-site machine learning analysis to explore brain structural patterns of T1 MRI data in 2668 ...
#1Gail Davies (Edin.: University of Edinburgh)H-Index: 52
#2Max LamH-Index: 10
Last.Ian J. Deary (Edin.: University of Edinburgh)H-Index: 128
view all 222 authors...
Christina M. Lill, who contributed to analysis of data, was inadvertently omitted from the author list in the originally published version of this article. This has now been corrected in both the PDF and HTML versions of the article.
#1Yongjie Yang (BCM: Baylor College of Medicine)H-Index: 9
#2Agatha A. van der Klaauw (University of Cambridge)H-Index: 16
Last.Weihua ZhangH-Index: 63
view all 265 authors...
Hypothalamic neurons expressing the anorectic peptide Pro-opiomelanocortin (Pomc) regulate food intake and body weight. Here, we show that Steroid Receptor Coactivator-1 (SRC-1) interacts with a target of leptin receptor activation, phosphorylated STAT3, to potentiate Pomc transcription. Deletion of SRC-1 in Pomc neurons in mice attenuates their depolarization by leptin, decreases Pomc expression and increases food intake leading to high-fat diet-induced obesity. In humans, fifteen rare heterozy...
#1Yanni Zeng (Edin.: University of Edinburgh)H-Index: 6
#2Carmen Amador (Edin.: University of Edinburgh)H-Index: 7
Last.Chris Haley (Edin.: University of Edinburgh)H-Index: 59
view all 23 authors...
In the original version of this Article, the legend in the upper panel of Figure 2 incorrectly read ‘paternal imprinting’ and should have read ‘maternal imprinting’. This has been corrected in both the PDF and HTML versions of the Article.
#1Qian Zhang (UQ: University of Queensland)H-Index: 50
#2Costanza L. Vallerga (UQ: University of Queensland)H-Index: 6
Last.Peter M. Visscher (UQ: University of Queensland)H-Index: 109
view all 33 authors...
DNA methylation changes with age. Chronological age predictors built from DNA methylation are termed ‘epigenetic clocks’. The deviation of predicted age from the actual age (‘age acceleration residual’, AAR) has been reported to be associated with death. However, it is currently unclear how a better prediction of chronological age affects such association. In this study, we build multiple predictors based on training DNA methylation samples selected from 13,661 samples (13,402 from blood and 259...
#1Darina Czamara (MPG: Max Planck Society)H-Index: 4
#2Gökcen Eraslan (TUM: Technische Universität München)H-Index: 4
Last.Elisabeth B. Binder (MPG: Max Planck Society)H-Index: 75
view all 229 authors...
Epigenetic processes, including DNA methylation (DNAm), are among the mechanisms allowing integration of genetic and environmental factors to shape cellular function. While many studies have investigated either environmental or genetic contributions to DNAm, few have assessed their integrated effects. Here we examine the relative contributions of prenatal environmental factors and genotype on DNA methylation in neonatal blood at variably methylated regions (VMRs) in 4 independent cohorts (overal...
#1Weihua Meng (Dund.: University of Dundee)H-Index: 11
#2Mark J. Adams (Edin.: University of Edinburgh)H-Index: 24
Last.Blair H. Smith (Dund.: University of Dundee)H-Index: 57
view all 12 authors...
Knee pain is one of the most common musculoskeletal complaints that brings people to medical attention. Approximately 50% of individuals over the age of 50 report an experience of knee pain within the past 12 months. We sought to identify the genetic variants associated with knee pain in 171,516 subjects from the UK Biobank cohort and seek supporting evidence in cohorts from 23andMe, the Osteoarthritis Initiative, and the Johnston County Osteoarthritis Project. We identified two loci that reache...
#1Xueyi Shen (Edin.: University of Edinburgh)H-Index: 7
#2Mark J. Adams (Edin.: University of Edinburgh)H-Index: 24
Last.Heather C. Whalley (Edin.: University of Edinburgh)H-Index: 47
view all 6 authors...
Abstract Background Studies of white matter microstructure in depression typically show alterations in individuals with depression, but they are frequently limited by small sample sizes and the absence of longitudinal measures of depressive symptoms. Depressive symptoms are dynamic, however, and understanding the neurobiology of different trajectories could have important clinical implications. Methods We examined associations between current and longitudinal measures of depressive symptoms and ...