Hyun Kyung Lim
Duksung Women's University
Publications 13
#1Seungeun LeeH-Index: 1
#2Eunhye LeeH-Index: 2
Last.Aree MoonH-Index: 28
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#1Seungeun Lee (Duksung Women's University)H-Index: 1
#2Eunhye Lee (Duksung Women's University)H-Index: 2
Last.Aree Moon (Duksung Women's University)H-Index: 28
view all 11 authors...
Abstract Tumor-associated macrophages (TAMs) are major components of tumor microenvironment that promote invasion and metastasis of cancer cells. In this study, we investigated the effect of TAMs on phenotypic conversion of non-neoplastic MCF10A human breast epithelial cells using an indirect co-culture system. Co-culture with TAMs induced epithelial-to-mesenchymal transition, invasive phenotype, and MMP-9 upregulation in MCF10A cells. Comparative proteomic analysis revealed that endoplasmic ret...
2 CitationsSource
#1Hyun Kyung LimH-Index: 4
#2Hyunsook LeeH-Index: 1
Last.Joohee JungH-Index: 9
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Predictive analytics play an important role in clinical research. An accurate predictive model can help clinicians stratify risk thereby allowing the identification of a target population which might benefit from a certain intervention. Conventionally, predictive analytics is performed using parametric modeling which comes with a number of assumptions. For example, generalized linear regression models require linearity and additivity to hold for the underlying data. However, these assumptions ma...
#1Hyun Kyung Lim (Duksung Women's University)H-Index: 4
#2Kyoung Mee Kim (Duksung Women's University)H-Index: 3
Last.Joohee Jung (Duksung Women's University)H-Index: 9
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Docetaxel (DTX) is an effective commercial anticancer agent for chemotherapy in non–small cell lung cancer (NSCLC), breast cancer, gastric cancer, and prostate cancer, but its adverse effects including edema, neurotoxicity, and hair loss limit its application. To improve the chemotherapeutic efficacy of DTX and reduce adverse effects, combination therapy is one of the alternative methods. So chrysin, which has various biological activities including anticancer effects, was considered. In vitro, ...
4 CitationsSource
9 CitationsSource
#1Joohee Jung (Duksung Women's University)H-Index: 9
#2Jisup Kim (Yonsei University)H-Index: 3
Last.Dong Sup Yoon (Yonsei University)H-Index: 23
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1 CitationsSource
Interest in marine bioresources is increasing in the drug development sector. In particular, marine sponges produce a wide range of unique metabolites that enable them to survive in challenging environments, which makes them attractive sources of candidate pharmaceuticals. In previous study, we investigated over 40 marine specimens collected in Micronesia and provided by the Korean Institute of Ocean Science and Technology, for their antiproliferative effects on various cancer cell lines, and Li...
1 CitationsSource
#1Hyun Kyung LimH-Index: 4
Last.Kyoung Mee KimH-Index: 3
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#1Jinhyang ChoiH-Index: 6
#2Eunjung KoH-Index: 1
Last.Eun Kyung ChoiH-Index: 23
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Nanoparticulation of insoluble drugs improves dissolution rate, resulting in increased bioavailability that leads to increased stability, better efficacy, and reduced toxicity of drugs. Docetaxel (DTX), under the trade name Taxotere™, is one of the representative anticancer chemotherapeutic agents of this era. However, this highly lipophilic and insoluble drug has many adverse effects. Our novel and widely applicable nanoparticulation using fat and supercritical fluid (NUFS™) technology enabled ...
7 CitationsSource
#1Kyoung Mee KimH-Index: 3
#2Hyun Kyung LimH-Index: 4
Last.Joohee JungH-Index: 12
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