Foo Kit Cheah
University of Malaya
Molecular biologyCytotoxic T cellApoptosisCytochrome cBiochemistry
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Publications 6
#1Foo Kit Cheah (UM: University of Malaya)H-Index: 5
#2Kok Hoong Leong (UM: University of Malaya)H-Index: 10
Last. Khalijah Awang (UM: University of Malaya)H-Index: 29
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Resveratrol, a naturally occurring polyphenolic antioxidant, is a potential chemoprophylactic agent for various cancers, including colorectal cancer. Although emerging evidence continually suggests that a number of resveratrol derivatives may be better cancer chemopreventive candidates than resveratrol, studies on the mechanism of action of these derivatives are limited. This is the first study which investigates the mechanism underlying the cytotoxic effect of a synthesized resveratrol analogue...
3 CitationsSource
#1Kok Hoong Leong (UM: University of Malaya)H-Index: 10
#2Chung Yeng Looi (UM: University of Malaya)H-Index: 23
Last. Khalijah Awang (UM: University of Malaya)H-Index: 29
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Plants in the Meliaceae family are known to possess interesting biological activities, such as antimalaral, antihypertensive and antitumour activities. Previously, our group reported the plant-derived compound cycloart-24-ene-26-ol-3-one isolated from the hexane extracts of Aglaia exima leaves, which shows cytotoxicity towards various cancer cell lines, in particular, colon cancer cell lines. In this report, we further demonstrate that cycloart-24-ene-26-ol-3-one, from here forth known as cycloa...
13 CitationsSource
#1Azeana Zahari (UM: University of Malaya)H-Index: 5
#2Foo Kit Cheah (UM: University of Malaya)H-Index: 5
Last. Khalijah Awang (UM: University of Malaya)H-Index: 29
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The crude extract of the bark of Dehaasia longipedicellata exhibited antiplasmodial activity against the growth of Plasmodium falciparum K1 isolate (resistant strain). Phytochemical studies of the extract led to the isolation of six alkaloids: two morphinandienones, (+)-sebiferine ( 1 ) and (−)-milonine ( 2 ); two aporphines, (−)-boldine ( 3 ) and (−)-norboldine ( 4 ); one benzlyisoquinoline, (−)-reticuline ( 5 ); and one bisbenzylisoquinoline, (−)- O - O- dimethylgrisabine ( 6 ). Their structur...
8 CitationsSource
#1Sook Yee LiewH-Index: 5
#2Chung Yeng LooiH-Index: 23
Last. Khalijah AwangH-Index: 29
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In this study, a new apoptotic monoterpenoid indole alkaloid, subditine (1), and four known compounds were isolated from the bark of Nauclea subdita. Complete 1H- and 13C- NMR data of the new compound were reported. The structures of isolated compounds were elucidated with various spectroscopic methods such as 1D- and 2D- NMR, IR, UV and LCMS. All five compounds were screened for cytotoxic activities on LNCaP and PC-3 human prostate cancer cell-lines. Among the five compounds, the new alkaloid, ...
18 CitationsSource
#1Chung Yeng Looi (UM: University of Malaya)H-Index: 23
#2Aditya Arya (UM: University of Malaya)H-Index: 16
Last. Mohd Rais Mustafa (UM: University of Malaya)H-Index: 27
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Background Centratherum anthelminticum (L.) seeds (CA) is a well known medicinal herb in Indian sub-continent. We recently reported anti-oxidant property of chloroform fraction of Centratherum anthelminticum (L.) seeds (CACF) by inhibiting tumor necrosis factor-α (TNF-α)-induced growth of human breast cancer cells. However, the active compounds in CACF have not been investigated previously. Methodology/Principal Findings In this study, we showed that CACF inhibited growth of MCF-7 human breast c...
57 CitationsSource
This study was set to investigate antiproliferative potential of dentatin (a natural coumarin isolated from Clausena excavata Burm. F) against prostate cancer and to delineate the underlying mechanism of action. Treatment with dentatin dose-dependently inhibited cell growth of PC-3 and LNCaP prostate cancer cell lines, whereas it showed less cytotoxic effects on normal prostate epithelial cell line (RWPE-1). The inhibitory effect of dentatin on prostate cancer cell growth was due to induction of...
36 CitationsSource