Match!
Jaewoong Jang
Chung-Ang University
12Publications
6H-index
90Citations
Publications 12
Newest
#1Taehyun Bae (CAU: Chung-Ang University)H-Index: 1
#2Jaewoong Jang (CAU: Chung-Ang University)H-Index: 6
Last.Yoosik Yoon (CAU: Chung-Ang University)H-Index: 21
view all 9 authors...
Abstract Ethnopharmacological relevance The dried root of Paeonia lactiflora Pall. (Radix Paeoniae) has been traditionally used to treat various inflammatory diseases in many Asian countries. Aim of the study Cancer cachexia is a catabolic syndrome driven by inflammation and characterised by a loss of skeletal muscle. This study aimed to assess the effects of an ethanolic extract of Radix Paeoniae (RP) on cancer cachexia and elucidate its mechanism of action. Material and methods The anti-cachex...
Source
#1Jaewoong Jang (CAU: Chung-Ang University)H-Index: 6
#2Yoonju Jung (CAU: Chung-Ang University)H-Index: 3
Last.Yoosik Yoon (CAU: Chung-Ang University)H-Index: 21
view all 8 authors...
AbstractAim: In this study, we report the anti-inflammatory activity of XAV939, a modulator of the Wnt/β-catenin pathway.Methods: WNT/β-catenin pathway and NF-κB signaling pathway were examined in LPS-stimulated human bronchial epithelial cells and effects of XAV939 on these pathways were analyzed. The effect of XAV939 was confirmed in human umbilical vein endothelial cells.Results: LPS-induced expressions of pro-inflammatory genes IL-6, IL-8, TNF-α, IL-1β, MCP-1, MMP-9, iNOS and COX-2 were sign...
2 CitationsSource
#1Jaewoong Jang (CAU: Chung-Ang University)H-Index: 6
#2Yoonju Jung (CAU: Chung-Ang University)H-Index: 3
Last.Yoosik Yoon (CAU: Chung-Ang University)H-Index: 21
view all 8 authors...
Abstract Ethnopharmacological relevance Gangjihwan (DF) which is composed of Ephedra intermedia , Lithospermum erythrorhizon , and Rheum palmatum has been used for the treatment of obesity in traditional medical clinics in Korea. Aim of the study This study was conducted to standardize DF and elucidate its mechanism of action for inhibiting fat accumulation in adipocytes and adipose tissues. Materials and methods The herbal ingredients of DF were extracted in water, 30% ethanol or 70% ethanol an...
3 CitationsSource
#1Jaewoong Jang (CAU: Chung-Ang University)H-Index: 6
#2Yoosik Yoon (CAU: Chung-Ang University)H-Index: 21
Last.Dong-Jin OhH-Index: 1
view all 3 authors...
Fractalkine (CX3CL1) is a chemokine with a unique CX3C motif and is produced by endothelial cells stimulated with lipopolysaccharide (LPS), tumor necrosis factor (TNF)-α, interleukin (IL)-1, and interferon-γ. There have been several reports that the caspase/calpain system is activated in endotoxemia, which leads to cellular apoptosis and acute inflammatory processes. We aimed to determine the role of the caspase/calpain system in cell viability and regulation of fractalkine production in LPS-tre...
1 CitationsSource
#1Jaewoong Jang (CAU: Chung-Ang University)H-Index: 6
#2Yoonju Jung (CAU: Chung-Ang University)H-Index: 3
Last.Yoosik Yoon (CAU: Chung-Ang University)H-Index: 21
view all 8 authors...
11 CitationsSource
#1Jaewoong Jang (CAU: Chung-Ang University)H-Index: 6
#2Yoonju Jung (CAU: Chung-Ang University)H-Index: 3
Last.Yoosik Yoon (CAU: Chung-Ang University)H-Index: 21
view all 6 authors...
Abstract In this study, TNF-α was found to activate the WNT/β-catenin pathway in BEAS-2B human bronchial epithelial cells. Levels of phospho-LRP6, Dvl-2, and phospho-GSK-3β were elevated, while that of Axin was reduced by TNF-α treatment. Nuclear translocation of β-catenin and the reporter activity of a β-catenin-responsive promoter were increased by TNF-α treatment. Under the same experimental conditions, TNF-α activated the NF-κB signaling, which includes the phosphorylation and degradation of...
7 CitationsSource
#1Jaewoong Jang (CAU: Chung-Ang University)H-Index: 6
#2Yoonju Jung (CAU: Chung-Ang University)H-Index: 3
Last.Yoosik Yoon (CAU: Chung-Ang University)H-Index: 21
view all 5 authors...
In this study, LPS-induced inflammatory responses in BEAS-2B human bronchial epithelial cells and human umbilical vein endothelial cell (HUVEC)s were found to be prevented by Dickkopf-1 (DKK-1), a secreted Wnt antagonist, and LGK974, a small molecular inhibitor of the Wnt secretion. LPS-induced IκB degradation and NF-κB nuclear translocation as well as the expressions of pro-inflammatory genes including IL-6, IL-8, TNF- α, IL-1β, MCP-1, MMP-9, COX-2 and iNOS, were all suppressed by DKK-1 and LGK...
20 CitationsSource
#1Jong-Hyeok Ha (CAU: Chung-Ang University)H-Index: 3
#2Jaewoong Jang (CAU: Chung-Ang University)H-Index: 6
Last.Yoosik Yoon (CAU: Chung-Ang University)H-Index: 21
view all 4 authors...
Abstract β-hydroxyisovalerylshikonin (β-HIVS), which is a natural naphthoquinone compound, is one of the main chemicals isolated from a therapeutic plant, Lithospermum erythrorhizon. In the present study, we demonstrated that β-HIVS inhibited the adipogenesis of 3T3-L1 cells through AMP-activated protein kinase (AMPK)-mediated modulation of sterol regulatory element binding protein (SREBP)‑1c. The anti-adipogenic effect of β-HIVS was accompanied by the increased phosphorylation of AMPK and precu...
10 CitationsSource
#1Jaewoong Jang (CAU: Chung-Ang University)H-Index: 6
#2Wonyong Kim (CAU: Chung-Ang University)H-Index: 24
Last.Yoosik Yoon (CAU: Chung-Ang University)H-Index: 21
view all 7 authors...
Abstract Lipoteichoic acid (LTA) is a major cell wall component and virulence factor of gram-positive bacteria. The present study investigated the LTA‑induced inflammatory response of BEAS‑2B human bronchial epithelial cells, and detected the expression levels of proinflammatory cytokines interleukin (IL)‑6, IL‑8, IL‑1β, tumour necrosis factor‑α and monocyte chemotactic protein‑1, the upregulation of NF‑κB, and the phosphorylation and degradation of I‑κB. During the LTA‑induced inflammatory resp...
2 CitationsSource
#1Jaewoong Jang (CAU: Chung-Ang University)H-Index: 6
#2Jong-Hyeok Ha (CAU: Chung-Ang University)H-Index: 3
Last.Yoosik Yoon (CAU: Chung-Ang University)H-Index: 21
view all 4 authors...
19 CitationsSource
12