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Torbjörn Bäckström
Umeå University
299Publications
55H-index
10.9kCitations
Publications 290
Newest
#1Magnus Löfgren (Umeå University)H-Index: 6
#2Ellinor Holmberg (Umeå University)H-Index: 4
Last.Suzanne L. Dickson (University of Gothenburg)H-Index: 46
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Abstract The progesterone metabolite, allopregnanolone (AlloP), is a GABA A receptor modulating steroid and is known to have orexigenic and pro-obesity effects. The neurobiological mechanisms underpinning these effects are most likely due to enhanced GABAergic signaling in the lateral arcuate nucleus (ARC) and medial paraventricular nucleus (PVN) of the hypothalamus. Inspired by the finding that GABAergic signaling is also important for the orexigenic effects of the circulating hormone, ghrelin,...
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#1Roberto Cadeddu (UofU: University of Utah)H-Index: 1
#2Torbjörn Bäckström (Umeå University)H-Index: 55
Last.Marco Bortolato (UofU: University of Utah)H-Index: 31
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#1Linda Ekenros (KI: Karolinska Institutet)H-Index: 3
#2Torbjörn Bäckström (Umeå University)H-Index: 55
Last.Cecilia Fridén (KI: Karolinska Institutet)H-Index: 11
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AbstractIt is not clear whether oral contraceptive (OC) treatment affects premenstrual symptoms in women. The aim of the present study was to evaluate changes in premenstrual symptoms (PMS) in women starting to use or discontinuing the use of OCs. Twenty-four healthy women with no previous diagnosis of premenstrual dysphoric disorder were included in this study with a prospective crossover design. Nineteen women completed daily ratings of somatic and mood symptoms during two hormonally different...
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#1Inger Sundström Poromaa (Uppsala University)H-Index: 19
#2Erika Comasco (Science for Life Laboratory)H-Index: 20
Last.Vibe G. Frokjaer (Copenhagen University Hospital)H-Index: 24
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Allopregnanolone is a metabolite of the sex hormone progesterone, with suggested relevance for female mood disorders. While allopregnanolone and serotonin are known to influence psychological well- ...
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#1Maja Johansson (KI: Karolinska Institutet)H-Index: 8
#2Maria Månsson (KI: Karolinska Institutet)H-Index: 1
Last.Torbjörn Bäckström (KI: Karolinska Institutet)H-Index: 55
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Rationale GR3027 is a novel small molecule GABA-A receptor-modulating steroid antagonist, which in non-clinical studies has shown promise for treatment of human disorders due to allosteric over-activation of GABA-A receptors by neurosteroids, such as allopregnanolone. We here studied its safety, pharmacokinetics, and ability to inhibit allopregnanolone effects in humans.
2 CitationsSource
#1Marie Bixo (Umeå University)H-Index: 28
#2Maja Johansson (Umeå University)H-Index: 8
Last.Torbjörn Bäckström (Umeå University)H-Index: 55
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Premenstrual dysphoric disorder (PMDD) afflicts 3%-5% of women of childbearing age, and is characterised by recurrent negative mood symptoms (eg, irritability, depression, anxiety and emotional lab ...
8 CitationsSource
#1Ellinor Holmberg (Umeå University)H-Index: 4
#2J. Sjöstedt (Umeå University)H-Index: 1
Last.Torbjörn Bäckström (Umeå University)H-Index: 55
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Obesity is strongly associated with ill health, primarily caused by consumption of excessive calories, and promoted (inter alia) by gamma-amino-butyric-acid (GABA) stimulating food intake by activa ...
4 CitationsSource
Abstract Objectives A follow-up study was performed on women who had requested medical abortions in a rural hospital in northern Norway to compare clinical assessment with self-assessment of early medical abortion in terms of safety. Study design During the three-year study period, 392 women requested termination of pregnancy. After excluding those who changed their mind, those who had a spontaneous miscarriage, those who were referred to a central hospital for a two-stage abortion, and those wh...
1 CitationsSource
#1Marie Bixo (Umeå University)H-Index: 28
#2Karin EkbergH-Index: 30
Last.Torbjörn Bäckström (Umeå University)H-Index: 55
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Context: Allopregnanolone is a metabolite from progesterone and a positive modulator of the GABAA receptor. This endogenous steroid may induce negative mood in sensitive women when present in serum ...
11 CitationsSource
#1Anette Lundqvist (Umeå University)H-Index: 4
#2Herbert Sandström (Umeå University)H-Index: 18
Last.Torbjörn Bäckström (Umeå University)H-Index: 55
view all 3 authors...
2 CitationsSource
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